Three new diterpene alkaloids,tangutidines A-C(1-3),and four known alkaloids(4-7)were isolated from the whole plant of Aconitum tanguticum,from which amphoteric diterpene alkaloids(1-3)were obtained for the first time...Three new diterpene alkaloids,tangutidines A-C(1-3),and four known alkaloids(4-7)were isolated from the whole plant of Aconitum tanguticum,from which amphoteric diterpene alkaloids(1-3)were obtained for the first time.The structures of 1-3 were elucidated by detailed interpretation of spectroscopic data,including MS and NMR data.All of them were evaluated for their cytotoxic activities.展开更多
Four new diterpenoids,laxiflorins S-V(1-4),bearing four different types,and one known compound,laxiflorin O(5),were isolated from Isodon eriocalyx var.laxiflora.Compound 1 was the first example of ent-kauranoids beari...Four new diterpenoids,laxiflorins S-V(1-4),bearing four different types,and one known compound,laxiflorin O(5),were isolated from Isodon eriocalyx var.laxiflora.Compound 1 was the first example of ent-kauranoids bearing a unique C_(24) carbon framework and compound 4 was the first example of 3,4-seco-ent-abietane diterpenoids from the Isodon genus.Their structures were determined by spectroscopic methods(UV,IR,MS,NMR).展开更多
基金the Second Tibetan Plateau Scientific Expedition and Research(STEP)program(2019QZKK0502)the National Natural Science Foundation of China(No.81673329)Authors are grateful for Dr.Ming Zhang from northwest institute of plateau biology,Chinese Academy of Sciences,for the assistance for obtaining plant materials.
文摘Three new diterpene alkaloids,tangutidines A-C(1-3),and four known alkaloids(4-7)were isolated from the whole plant of Aconitum tanguticum,from which amphoteric diterpene alkaloids(1-3)were obtained for the first time.The structures of 1-3 were elucidated by detailed interpretation of spectroscopic data,including MS and NMR data.All of them were evaluated for their cytotoxic activities.
基金This project was supported financially by the National Natural Science Foundation of China(No.81172939)the West Light Foundation of the Chinese Academy of Sciences(J.X.Pu)+3 种基金the Major State Basic Research Development Program of China(No.2009CB522300)the reservation talent project of Yunnan Province(2011CI043 to J.X.Pu)the Science and Technology Program of Yunnan Province(Nos.2008IF010)the Major Direction Projection Foundation of CAS Intellectual Innovation Project(No.KSCX2-EW-J-24 to J.X.Pu).
文摘Four new diterpenoids,laxiflorins S-V(1-4),bearing four different types,and one known compound,laxiflorin O(5),were isolated from Isodon eriocalyx var.laxiflora.Compound 1 was the first example of ent-kauranoids bearing a unique C_(24) carbon framework and compound 4 was the first example of 3,4-seco-ent-abietane diterpenoids from the Isodon genus.Their structures were determined by spectroscopic methods(UV,IR,MS,NMR).
