Application of positive behavior management in patients after breast cancer surgery

BACKGROUND As a radical treatment,breast cancer surgery has a positive psychological impact on most patients.However,some patients do not have a clear understanding of the disease,which requires a more scientific and comprehensive consideration during clinical intervention and are based on cognition.The positive behavior management model is based on this kind of background-derived new interventions,which can better serve the clinical rehabilitation process of patients.The positive behavior management model based on cognitive architecture is a new type of intervention derived from this background,which can better serve the clinical rehabilitation process of patients.AIM To analyze the influence of a positive behavior management model based on cognitive framework on the degree of hope and self-efficacy of patients with breast cancer surgery.METHODS Eighty-four patients with breast cancer who underwent surgical treatment in our hospital from August 2016 to December 2018 were included in the study.The patients were divided into the experimental group(n=42)and control group(n=42)by random number table grouping.The control group received traditional nursing intervention,while the experimental group received a positive behavior management model based on cognitive framework based on the traditional intervention of the control group.General Self-efficacy Scale,Herth Hope Scale,Self-Rating Anxiety Scale,Self-Rating Depression Scale and Cancer Patient Specific Scale were used to evaluate the two groups before and 1 wk after intervention.RESULTS After the intervention,self-efficacy and hope level of the experimental group were significantly higher than those of the control group(P<0.05).The Self-Rating Anxiety Scale and Self-Rating Depression Scale scores in the experimental group were significantly lower than those in the control group(P<0.05).There was no significant difference in the quality of life scores between the two groups before intervention(P>0.05).The quality of life scores in all aspects in the experimental group after intervention were significantly higher than those in the control group(P<0.05).CONCLUSION The positive behavior management model based on cognitive framework applied to patients with breast cancer surgery improved hope for treatment and selfefficacy,reduced negative emotion,and improved quality of life.

Decreased expression of gap junction delta-2 (GJD2) messenger RNA and connexin 36 protein in form-deprivation myopia of guinea pigs

Background:More than ten genome-wide association studies have identified the significant association between the gap junction delta-2 (GJD2) gene and myopia.However,no functional studies have been performed to confirm that this gene is correlated with myopia.This study aimed to observe how this gene changed in mRNA and protein level in the form-deprivation myopia (FDM) animal model.Methods:Four-week-old guinea pigs were randomly divided into two groups:control and FDM groups (n =12 for each group).The right eyes of the FDM group were covered with opaque hemispherical plastic lenses for 3 weeks.For all the animals,refractive status,axial length (AL),and corneal radius of curvature were measured at baseline and 3 weeks later by streak retinoscope,A-scan ultrasonography,and keratometer,respectively.Retinal GJD2 mRNA expression and connexin 36 (Cx36) levels in FDM and control groups were measured by quantitative real-time PCR and Western blot analyses,respectively.Those results were compared using independent t test,Mann-Whitney U test,or paired t test.A significance level of P < 0.05 was used.Results:Three weeks later,the FDM group (form-deprived eyes) showed about a myopic shift of approximately-6.75 (-7.94 to -6.31) D,while the control group remained hyperopic with only a shift of-0.50 (-0.75 to 0.25) D (Z =-3.38,P < 0.01).The AL increased by 0.74 (0.61-0.76) and 0.10 (0.05-0.21) mm in FDM and control groups,respectively (Z =-3.37,P < 0.01).The relative mRNA expression of GJD2 in the FDM group decreased 31.58% more than the control group (t =11.44,P < 0.01).The relative protein expression of CX36 on the retina was lowered by 37.72% in form-deprivation eyes as compared to the controls (t=17.74,P < 0.01).Conclusion:Both the mRNA expression of GJD2 and Cx36 protein amount were significantly decreased in the retina of FDM guinea pigs.This indicates that Cx36 is involved in FDM development,providing compensating evidence for the results obtained from genome-wide association studies.

Weill-Marchesani-like syndrome caused by an FBN1 mutation with low-penetrance

Weill-Marchesani syndrome(WMS)is a rare connective tissue disorder characterized by brachydactyly,short stature,joint stiffness,cardiovascular abnormalities,and eye anomalies including microspherophakia,cataracts,ectopia lentis,myopia,and secondary glaucoma.Patients with incomplete WMS signs are diagnosed with Weill-Marchesani-like syndrome(WMS-like).To date,both autosomal dominant(AD)and autosomal recessive(AR)inheritance modes have been reported for WMS.Genetic heterogeneity inWMSsuggests a connection between these genes.AR and AD WMS cannot be distinguished clearly by clinical findings alone.[1]Furthermore,inter-familial as well as intra-familial clinical variability due to different fibrillin-1 gene(FBN1)mutations also exists.