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NR4A1 agonist cytosporone B attenuates neuroinflammation in a mouse model of multiple sclerosis
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作者 Hai-Zhen Yu bing-qing zhu +2 位作者 Lin zhu Shuo Li Li-Mei Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第12期2765-2770,共6页
Nuclear receptor subfamily 4 group A1(NR4A1)is an orphan nuclear receptor,which is expressed in the majority of cells.NR4A1 expression in peripheral blood mononuclear cells is low during the preclinical stage of multi... Nuclear receptor subfamily 4 group A1(NR4A1)is an orphan nuclear receptor,which is expressed in the majority of cells.NR4A1 expression in peripheral blood mononuclear cells is low during the preclinical stage of multiple sclerosis.Knockout of the Nr4a1 gene in mice can aggravate the symptoms of experimental autoimmune encephalomyelitis(EAE),which is an animal model of multiple sclerosis.In this study,we intragastrically administered the NR4A1 agonist cytosporone B(Csn-B)to mice after inducing EAE.After treatment with Csn-B,the clinical symptoms in the EAE mice were substantially attenuated compared with that in PBS-treated control mice.The percentages of CD4+T cells and F4/80+cells in the central nervous system were decreased.In addition,interferon-γand interleukin-17 production by proinflammatory Th1/Th17 cells in the central nervous system and interferon-γlevels in splenocytes were decreased after Csn-B treatment.These findings suggest that the NR4A1 agonist Csn-B can alleviate nerve injury after EAE induction,and,therefore,may be useful as a potential treatment for multiple sclerosis. 展开更多
关键词 cytosporone B(Csn-B) experimental autoimmune encephalomyelitis MACROPHAGES MICROGLIA multiple sclerosis NR4A1 agonist NR4A1 TH1 TH17 treatment
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