Impact of motivational interviewing on the quality of life and its related factors in type 2 diabetes mellitus patients with poor long-term glycemic control

Purpose:The aim of this study was to evaluate the impact of motivational interviewing(MI)on the quality of life and its related factors in type 2 diabetes mellitus(T2DM)patients with poor long-term glycemic control.Design and methods:One hundred tenT2DMpatientswithpoor long-termglycemic control that were hospitalized in our institution were enrolled in this study and randomly assigned to receive eitherMI or routine diabetes education intervention.Patients'body mass index values,Homeostatic Model Assessment-Insulin Resistance(HOMA-IR)scores,and levels of glycated hemoglobin(HbA1C),triglycerides,high-and low-density lipoproteincholesterols,Summary of Diabetes Self-management Activities and Diabetes Specific Quality of Life assessments were recorded before and six months after intervention.Results:Baseline scores for all measurements did not differ between patients in the control and MI groups.Although MI resulted in a significant reduction of HbA1c and serum lipid levels compared with the baseline,the effect was not significantly different from the control intervention.However,the improvement in HOMA-IR scores was significantly greater in the MI group compared with the control intervention(2.8±2.8 vs.5.7±4.7;p=0.000).Moreover,MI significantly elevated diabetes self-management activities ratings compared with the control intervention(13.2±3.4 vs.10.9±4.3;p=0.004).Conclusion:Compared to routine diabetes education,MI is a more effective approach for improving HOMA-IR and self-management of T2DM patients with poor long-term glycemic control.

A Study on Neonatal Tolerance Against Graves＇ Disease in BALB/c Mice

INTRODUCTION Autoimmunity is defined as, a condition characterized by a specific humoral or cell-mediated immune response against the constituents of the body＇s own tissues （autoantigens）. In numerous autoimmune diseases, such an immune response is well recognized that causes damage to the self-constituents of body tissues by the products of the immune system. Graves＇ hyperthyroidism occurs after the loss of tolerance to the thyroid stimulating hormone receptor （TSHR） and the generation of thyroid stimulatory antibodies that mimic the action of thyroid-stimulating hormone （TSH）.

High-fat diet-induced adipose tissue expansion occurs prior to insulin resistance in C57BL/6J mice

Background::To date,there is only scare evidence characterizing the temporal features and progression of metabolic dysfunction in high-fat diet(HFD)-fed obese mice.Hence,its specific pathogenesis remains unclear.Methods::Sixty 6-week-old male C57BL/6J mice were randomly divided into HFD and control diet(CD)groups and sacrificed at 1,5,9,13,17,and 21 weeks,respectively.At weekly intervals,intraperitoneal glucose tolerance testing(IPGTT)and intraperitoneal insulin tolerance testing(IPITT)were performed in both groups.A detailed time course in HFD-fed mice was investigated by evaluating the initiation of glucose homeostasis impairment,dyslipidemia,systemic insulin sensitivity,monocyte chemoattractant protein-1(MCP-1)levels,epididymal white adipose tissue(eWAT)expansion,macrophage content changes,proinflammatory(M1)/anti-inflammatory(M2)macrophage imbalance,lipid accumulation in the liver,andβ-cell morphometry in the pancreas.Results::In the HFD group,progressive weight gain and impairments in glucose metabolism(elevated fasting blood glucose and area under the curve(AUC)of IPGTT)were observed from the 3rd week,and a significantly elevated AUC of IPITT was first detected after week 7 of HFD feeding.As for dyslipidemia,after 9 weeks of feeding,the low-density lipoprotein cholesterol level and total cholesterol level in HFD group were significantly higher than those in the CD group(all P<0.05),whereas no significant differences were shown in triglyceride level.Adipocyte size increased significantly in the HFD group in the 1st week,a phenotypic switch in eWAT from anti-inflammatory(M2)to pro-inflammatory(M1)macrophages was observed in the 5th week,and the metabolic inflammation was distinct in eWAT in the 9th week.Additionally,liver steatosis was considerably obvious at the 17th week and pancreaticβ-cell morphometry did not change during 21 weeks of HFD feeding.Conclusion::The eWAT expansion was detected early in HFD-induced obese mice,which occurred prior to obvious insulin resistance.