An anti-aging skin strategy:promoting repair and regeneration in UV-induced photoaging micro-environment using growth factors-rich platelet lysates composite Self-protection Collagen Hydrogel

Skin photoaging is induced and sustained by UV-induced oxidative damage,and stimulating regeneration of the UV-induced aging has remained a great challenge due to high-level oxidative stress factor(ROS)-induced chronic oxidative damage and inactivation of bio-macromolecule-based regeneration in oxidative photoaging micro-environment.In this study,we designed a“seed and soil”strategy to pursue a safer and more efficient way to prevent and treat photoaging by simultaneously changing UV-induced ROS-rich micro-environment into a proregenerative one(the“soil”)and providing growth factor-rich platelet lysates(PL,the“seed”)using PL-impregnated,collagen-reinforce hydrogel(PL/Col).SD rats were used to establish photoaging model by 8 weeks of UV irradiation.The effectiveness of different treatments was evaluated by making pathological sections and detecting photoaging-related indicators.Rats treated with PL/Col demonstrated a significant acceleration in skin healing and enhancement in the quality of trauma repairing.After treated with PL/Col,the rats showed smooth yellowish appearance,integral structure of skin collagen fiber and epidermis,a decrease in inflammation and a reshaped active micro-environment with reduced levels of SOD enzyme activity,GSH enzyme activity and MDA toxic products.Treatment of PL/Col in skin photoaging has shown potential anti-oxidation and anti-aging effects and is worthy of further study in related field.

Ipsilateral hemifacial microsomia with dextrocardia and pulmonary hypoplasia:A case report

BACKGROUND Hemifacial microsomia(HFM)is a rare congenital malformation characterized by a combination of various anomalies,including the face,ears,eyes,and vertebrae.Prenatal diagnosis for HFM is possible,and quite accurate ultrasound can detect obvious defects.The etiology is still unknown,although some hypotheses have been proposed,including gene mutation,chromosome anomaly,and environmental risk factors.However,there are few reports of pulmonary hypoplasia and dextrocardia in HFM.CASE SUMMARY A 2-year-old boy presented to the ear reconstruction department of our hospital complaining of deviation of the face to the right side and auricular anomaly.Physical examination revealed facial asymmetry,preauricular skin tags,and concha-type microtia with stricture of the external auditory canal on the right side.Head magnetic resonance imaging showed bilateral semicircular canal dysplasia and bilateral internal auditory canals stenosis.Audiometric examination showed bilateral severe sensorineural hearing loss.Chest radiography and computed tomography showed dextrocardia and right pulmonary hypoplasia.CONCLUSION This case presented a rare finding and an unusual association of 3 malformations,ipsilateral HFM,pulmonary agenesis,and dextrocardia.

基于幂律流体模型的非牛顿流体对斯特封密封行为影响的仿真研究（英文）

目的:研究润滑油的非牛顿流体行为对液压往复活塞杆的斯特封密封性能的影响,为密封设计提供理论参考。创新点:1.基于幂律流体模型和JFO空化理论,推导出同时考虑粗糙度、流体空化和非牛顿流体效应的修正雷诺方程;2.建立非牛顿流体的混合润滑软弹流模型,探究流体流变属性对斯特封密封行为及性能的影响。方法:1.通过理论推导,建立混合润滑条件下非牛顿流体的软弹流仿真模型;2.对比分析不同工况条件下假塑性(n<1)、膨胀型(n>1)两种典型非牛顿流体和牛顿流体(n=1)对斯特封密封行为影响的区别,揭示假塑性和膨胀型两种非牛顿流体的密封机理。结论:1.非牛顿流体效应对液压往复斯特封密封性能具有重要影响:幂律指数越大,流体的动压效应越强,密封性能越好。2.相比于牛顿流体,膨胀型流体润滑条件较好,密封具有低摩擦低泄漏的优点;假塑性流体润滑条件较差,密封摩擦力较大,不易实现零泄漏。