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Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin 被引量:16
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作者 Liye Wang Yuehan Song +8 位作者 Feng Li Yan Liu Jie Ma Meng Mao Fengzhi Wu Ying Wu Sinai Li binghe guan Xiaolan Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2014年第2期205-212,共8页
Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medi- cine remedy Wen Dan Tang reduces ... Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medi- cine remedy Wen Dan Tang reduces insomnia-related anxiety, which may perhaps correspond to changes in the brain-gut axis. This suggests a possible relationship between Wen Dan Tan^s pharmacological mechanism and the brain-gut axis. Based on this hypothesis, a sleep-deprived rat model was induced and Wen Dan Tang was administered using oral gavage during model es- tablishment. Wen Dan Tang significantly reduced insomnia-related anxiety and prevented Ghrelin level decreases following sleep deprivation, especially in the hypothalamus. Increased expression of Ghrelin receptor mRNA in the hypothalamus was also observed, suggesting that reduced anxi- ety may be a result of Wen Dan Tan's regulation of Ghrelin-Ghrelin receptors. 展开更多
关键词 nerve regeneration Chinese Medicine Wen Dan Tang sleep deprivation ANXIETY GHRELIN Ghrelin receptor the National Natural Science Youth Foundation in China neural regeneration
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