Suzuki-Miyaura reaction of aryl halides with phenylboronic acid using a heterogeneous palladium catalyst based on activated carbons(AC) was systematically investigated in this work. Two different reaction modes(batch ...Suzuki-Miyaura reaction of aryl halides with phenylboronic acid using a heterogeneous palladium catalyst based on activated carbons(AC) was systematically investigated in this work. Two different reaction modes(batch procedure and continuous-flow procedure) were used to study the variations of reaction processing. The heterogeneous catalysts presented excellent reactivity and recyclability for iodobenzene and bromobenzene substrates in batch mode, which can be attributed to stabilization of Pd nanoparticles by the thiol and amino groups on the AC supports. However, significant dehalogenation in the reaction mixture and Pd leaching from the heterogeneous catalysts were observed in continuous-flow mode.This unique phenomenon in continuous-flow mode resulted in a dramatic decline in reaction selectivity and durability of heterogeneous catalysts comparing with that of batch mode. In addition, the heterogeneous Pd catalysts with thiol-and amino-modified AC supports exhibited different reactivity and durability in batch and continuous-flow mode owing to the difference of interaction between Pd species and AC supports.展开更多
Recently,the continuous tube-in-tube reactor based on the Teflon AF membrane is emerging as a powerful toolkit for accelerating gas-liquid mass transfer and reaction rate.Because of its large gas-liquid interfacial ar...Recently,the continuous tube-in-tube reactor based on the Teflon AF membrane is emerging as a powerful toolkit for accelerating gas-liquid mass transfer and reaction rate.Because of its large gas-liquid interfacial area and short mass transfer distance,the reactor can allow a fast gas-liquid mass transfer without direct contact between gas and liquid phases,offering an efficient and safe platform for implementing gas-liquid reaction and rapid determination of gas-liquid parameters.In this review,a detailed description and construction method of this reactor are pro-vided.Then,the recent advancements of the tube-in-tube reactor in fundamental studies and practical applica-tions in gas-involved chemical reactions and biosynthetic processes are discussed.Finally,a perspective on future potential applications of such flow reactors is provided.展开更多
基金the support of the National Natural Science Foundation of China (20222809, 21978146)TsinghuaFoshan Innovation Special Fund (2021THFS0214)。
文摘Suzuki-Miyaura reaction of aryl halides with phenylboronic acid using a heterogeneous palladium catalyst based on activated carbons(AC) was systematically investigated in this work. Two different reaction modes(batch procedure and continuous-flow procedure) were used to study the variations of reaction processing. The heterogeneous catalysts presented excellent reactivity and recyclability for iodobenzene and bromobenzene substrates in batch mode, which can be attributed to stabilization of Pd nanoparticles by the thiol and amino groups on the AC supports. However, significant dehalogenation in the reaction mixture and Pd leaching from the heterogeneous catalysts were observed in continuous-flow mode.This unique phenomenon in continuous-flow mode resulted in a dramatic decline in reaction selectivity and durability of heterogeneous catalysts comparing with that of batch mode. In addition, the heterogeneous Pd catalysts with thiol-and amino-modified AC supports exhibited different reactivity and durability in batch and continuous-flow mode owing to the difference of interaction between Pd species and AC supports.
基金We gratefully acknowledge the supports of National Key Research and Development Program of China(2019YFA0905100)Tsinghua-Foshan Innovation Special Fund(2021THFS0214)the National Natural Science Foundation of China(21978146,22022809)on this work.
文摘Recently,the continuous tube-in-tube reactor based on the Teflon AF membrane is emerging as a powerful toolkit for accelerating gas-liquid mass transfer and reaction rate.Because of its large gas-liquid interfacial area and short mass transfer distance,the reactor can allow a fast gas-liquid mass transfer without direct contact between gas and liquid phases,offering an efficient and safe platform for implementing gas-liquid reaction and rapid determination of gas-liquid parameters.In this review,a detailed description and construction method of this reactor are pro-vided.Then,the recent advancements of the tube-in-tube reactor in fundamental studies and practical applica-tions in gas-involved chemical reactions and biosynthetic processes are discussed.Finally,a perspective on future potential applications of such flow reactors is provided.
