Empirical Study on the Relationship between Economic Development and Urban Construction Land in China: Based on the Panel Data of Provinces

The panel data of 31 provinces,cities and autonomous regions was used in order to test the relationship between economic development and urban land. The result showed that the sequences of economic development and urban land were in accordance with first order integration. Secondly,there was cointegration between economic development and urban land and the cointegration equation illustrated that 10% of increase in GDP per capita would drive 4. 94% of expansion in city construction land. Thirdly,according to error correction model,economic development is the Granger cause of urban land expansion in the long term while the reverse relationship was not proved. In short-term,economic development and urban land expansion were Granger causes of each other. The long-term equilibrium can only regulate the short-term imbalance of urban land,arriving at 33. 83%. Therefore,the government should formulate related policies to encourage real estate developers and enterprises to increase land utilization efficiency,strictly control the increase of urban land and regulate short-term imbalance.

The Expression and Clinical Significance of Sema4A in Triple Negative Breast Cancer

Objective:To explore the expression and clinical significance of Sema4A in triple-negative breast cancer.Metlods:Eighty patients with invasive ductal carcinoma of the breast and 40 normal tissues adjacent to cancer were selected.Immumohistochemical methods were used to detect the expression of Sema4A in breast cancer and normal tissues adjacent to cancer,and its relationship with breast cancer clinicopathological features and prognosis.Results:The expression of Sema4a in the serum of BCA patients was significantly higher than that of healthy controls.In addition,the expression of sema4a in BCA cells and in the cell supernatants was also up-regulated under hypoxia.Conclusion:Exogenous Sema4A can protect BCA cells from hypoxia-induced cytotoxicity,inhibit cell apoptosis and promote cell proliferation.

Exploration of potential mechanisms for the treatment of ulcerative colitis by Solanum diphyllum L.based on network pharmacology and molecular docking

Evidence of the advantages of Solanum nigrum L.for the treatment of ulcerative colitis is accumulating.However,research revealing the treatment of Solanum diphyllum L.against ulcerative colitis is scarce.In this study,the chemical components of the extract of Solanum diphyllum L.were characterized by LC-MS/MS,identifying 31 compounds by positive and negative total ion flow maps.A total of 425 component target genes and 1900 disease target genes were obtained,and 121 intersection targets and 6 core targets were obtained after the intersection of the two genes by means of network pharmacology.GO analysis and KEGG analysis respectively obtained 20 signaling pathways such as anti-infl ammation.The results of molecular docking showed that the chemical components could successfully dock with the target proteins of the disease such as SRC,EGFR,PTGS2,MMP9,HSP90AA1,ESR1.This study provided a scientifi c basis for the development and application of Solanum diphyllum L.