Urinary C-peptide Creatinine Ratio and Its Correlation with Parameters of Metabolic Syndrome

To assess the correlation between urinary C peptide creatinine ratio with serum C peptide,serum insulin and its correlation with clinical and biochemical parameters of metabolic syndrome.A total of 100 subjects more than 18 years of age with metabolic syndrome according to ATP Ⅲ criteria with 100 controls were included in a prospective observational study for a period of 1.5 years.Individual parameters of metabolic syndrome was higher in females with hypertriglyceridemia was most common and hyperglycaemia least common parameter of metabolic syndrome.Fasting urinary C peptide creatinine ratio and Stimulated urinary C peptide correlate significantly with fasting serum C peptide(p<0.01),stimulated serum C peptide(p<0.01),serum fasting insulin(p<0.01)and HOMA IR(p<0.01).A fasting urinary C peptide creatinine ratio of more than 1.8 nmol/mmol,stimulated urinary C peptide creatinine ratio more than 2.8 nmol/mmol and HOMA IR>2.7 can be used as a parameter to distinguish individual with and without metabolic syndrome.Urinary C peptide creatinine ratio correlate with serum C peptide and parameters of metabolic syndrome and can be used as a non-invasive simple tool to assess insulin resistance and also to distinguish patients with and without metabolic syndrome.