For neighborhood rough set attribute reduction algorithms based on dependency degree,a neighborhood computation method incorporating attribute weight values and a neighborhood rough set attribute reduction algorithm u...For neighborhood rough set attribute reduction algorithms based on dependency degree,a neighborhood computation method incorporating attribute weight values and a neighborhood rough set attribute reduction algorithm using discernment as the heuristic information was proposed.The reduction algorithm comprehensively considers the dependency degree and neighborhood granulation degree of attributes,allowing for a more accurate measurement of the importance degrees of attributes.Example analyses and experimental results demonstrate the feasibility and effectiveness of the algorithm.展开更多
Targeting the white-to-brown fat conversion is important for developing potential strategies to counteract metabolic diseases;yet the mechanisms are not fully understood.Yes-associated-protein(YAP),a transcription co-...Targeting the white-to-brown fat conversion is important for developing potential strategies to counteract metabolic diseases;yet the mechanisms are not fully understood.Yes-associated-protein(YAP),a transcription co-activator,was demonstrated to regulate adipose tissue functions;however,its effects on browning of subcutaneous white adipose tissue(sWAT)are unclear.We demonstrated that YAP was highly expressed in cold-induced beige fat.Mechanistically,YAP was found as a target gene of miR-429,which downregulated YAP expression in vivo and in vitro.In addition,miR-429 level was decreased in cold-induced beige fat.Additionally,pharmacological inhibition of the interaction between YAP and transcriptional enhanced associate domains by verteporfin dampened the browning of sWAT.Although adipose tissue-specific YAP overexpression increased energy expenditure with increased basal uncoupling protein 1 expression,it had no additional effects on the browning of sWAT in young mice.However,we found age-related impairment of sWAT browning along with decreased YAP expression.Under these circumstances,YAP overexpression significantly improved the impaired WAT browning in middle-aged mice.In conclusion,YAP as a regulator of sWAT browning,was upregulated by lowering miR-429 level in cold-induced beige fat.Targeting the miR-429-YAP pathway could be exploited for therapeutic strategies for age-related impairment of sWAT browning.展开更多
基金Anhui Provincial University Research Project(Project Number:2023AH051659)Tongling University Talent Research Initiation Fund Project(Project Number:2022tlxyrc31)+1 种基金Tongling University School-Level Scientific Research Project(Project Number:2021tlxytwh05)Tongling University Horizontal Project(Project Number:2023tlxyxdz237)。
文摘For neighborhood rough set attribute reduction algorithms based on dependency degree,a neighborhood computation method incorporating attribute weight values and a neighborhood rough set attribute reduction algorithm using discernment as the heuristic information was proposed.The reduction algorithm comprehensively considers the dependency degree and neighborhood granulation degree of attributes,allowing for a more accurate measurement of the importance degrees of attributes.Example analyses and experimental results demonstrate the feasibility and effectiveness of the algorithm.
基金the National Key Research and Development Program of China(2019YFA0802502)the National Natural Science Foundation of China(81770836,81822006,81700506)the Natural Science Foundation of Tianjin(19JCQNJC10100).
文摘Targeting the white-to-brown fat conversion is important for developing potential strategies to counteract metabolic diseases;yet the mechanisms are not fully understood.Yes-associated-protein(YAP),a transcription co-activator,was demonstrated to regulate adipose tissue functions;however,its effects on browning of subcutaneous white adipose tissue(sWAT)are unclear.We demonstrated that YAP was highly expressed in cold-induced beige fat.Mechanistically,YAP was found as a target gene of miR-429,which downregulated YAP expression in vivo and in vitro.In addition,miR-429 level was decreased in cold-induced beige fat.Additionally,pharmacological inhibition of the interaction between YAP and transcriptional enhanced associate domains by verteporfin dampened the browning of sWAT.Although adipose tissue-specific YAP overexpression increased energy expenditure with increased basal uncoupling protein 1 expression,it had no additional effects on the browning of sWAT in young mice.However,we found age-related impairment of sWAT browning along with decreased YAP expression.Under these circumstances,YAP overexpression significantly improved the impaired WAT browning in middle-aged mice.In conclusion,YAP as a regulator of sWAT browning,was upregulated by lowering miR-429 level in cold-induced beige fat.Targeting the miR-429-YAP pathway could be exploited for therapeutic strategies for age-related impairment of sWAT browning.
