Aim: To compare the growth and neurodevelopment of low birthweight (LBW) and n ormal-birthweight (control) infants born and raised in China. Design: Prospecti ve cohort study. Subjects and setting: 203 LBW (1200-2499 ...Aim: To compare the growth and neurodevelopment of low birthweight (LBW) and n ormal-birthweight (control) infants born and raised in China. Design: Prospecti ve cohort study. Subjects and setting: 203 LBW (1200-2499 g) and 71 control (≥ 2500 g) infants born at two Shanghai hospitals in 1983 did not differ for date o f birth, gender, parental occupation, parental weight and age. LBW < 10th centil e at ≥37 wk gestation was defined as small for gestational age (SGA, n = 102). LBW at < 37 wk gestation was defined as preterm (n = 101). Main outcome measures : Weight, height, head circumference, Gesell developmental quotient (DQ), Wechsl er intelligence quotient (IQ), and scholastic achievement score. Results: Of the 274 enrolled subjects, 234 (85%) returned at 6 mo, 135 (49%) at 6 y, and 104 (38%) at 16 y. SGA, preterm, and control subjects did not differ in rates of fo llow-up or baseline characteristics. However, SGA and preterm were lower than c ontrol subjects in weight and head circumference through 16 y, height through 4 y, DQ through 3 y, IQ at 5 and 16 y, and scholastic achievement at 16 y. Catch-up to growth in the control group, defined as > 3rd centile, and normal IQ, defi ned as ≥85, were both more common among preterm than SGA subjects. Conclusions: Adolescents in China with birthweights of 1200-2499 g, and particularly those who were SGA, lag behind peers with birthweights > 2500 g in physical growth, co gnitive capacity, and school achievement. The findings suggest that LBW adolesce nts in China today represent a population in need of evaluation and support.展开更多
文摘Aim: To compare the growth and neurodevelopment of low birthweight (LBW) and n ormal-birthweight (control) infants born and raised in China. Design: Prospecti ve cohort study. Subjects and setting: 203 LBW (1200-2499 g) and 71 control (≥ 2500 g) infants born at two Shanghai hospitals in 1983 did not differ for date o f birth, gender, parental occupation, parental weight and age. LBW < 10th centil e at ≥37 wk gestation was defined as small for gestational age (SGA, n = 102). LBW at < 37 wk gestation was defined as preterm (n = 101). Main outcome measures : Weight, height, head circumference, Gesell developmental quotient (DQ), Wechsl er intelligence quotient (IQ), and scholastic achievement score. Results: Of the 274 enrolled subjects, 234 (85%) returned at 6 mo, 135 (49%) at 6 y, and 104 (38%) at 16 y. SGA, preterm, and control subjects did not differ in rates of fo llow-up or baseline characteristics. However, SGA and preterm were lower than c ontrol subjects in weight and head circumference through 16 y, height through 4 y, DQ through 3 y, IQ at 5 and 16 y, and scholastic achievement at 16 y. Catch-up to growth in the control group, defined as > 3rd centile, and normal IQ, defi ned as ≥85, were both more common among preterm than SGA subjects. Conclusions: Adolescents in China with birthweights of 1200-2499 g, and particularly those who were SGA, lag behind peers with birthweights > 2500 g in physical growth, co gnitive capacity, and school achievement. The findings suggest that LBW adolesce nts in China today represent a population in need of evaluation and support.
