The safety of beta-glucans, including undenatured beta-glucan (UDBG), has been exhaustively studied over the recent past and has shown to be safe and efficacious in rodents as well as in humans with less than optimal ...The safety of beta-glucans, including undenatured beta-glucan (UDBG), has been exhaustively studied over the recent past and has shown to be safe and efficacious in rodents as well as in humans with less than optimal immune systems. As such, we sought to find the effect of UDBG on certainly stressed crustaceans and fish. The survival of shrimp larvae fed the UDBG and other diets was measured on day 16. The diet containing 11.7% UDBG reduced larvae mortality by 18%;which is almost twice as much as the mortality reduced by the MacroGard diet, and up to 19.5% less than a standard Commercial Diet. In an effort to understand how UDBG protects against stressed marine life, UDBG was given to LPS-challenged trout. The UDBG positively influenced the level of transcription of several genes relevant to the immune system and overall health of the trout. The experimental findings indicated that UDBG: 1) modifies inflammatory responses, 2) makes responses more flexible and versatile, 3) protects from cellular stress, and 4) enhances “effector” mechanisms. Importantly, there was no evidence of immune system over-activity.展开更多
文摘The safety of beta-glucans, including undenatured beta-glucan (UDBG), has been exhaustively studied over the recent past and has shown to be safe and efficacious in rodents as well as in humans with less than optimal immune systems. As such, we sought to find the effect of UDBG on certainly stressed crustaceans and fish. The survival of shrimp larvae fed the UDBG and other diets was measured on day 16. The diet containing 11.7% UDBG reduced larvae mortality by 18%;which is almost twice as much as the mortality reduced by the MacroGard diet, and up to 19.5% less than a standard Commercial Diet. In an effort to understand how UDBG protects against stressed marine life, UDBG was given to LPS-challenged trout. The UDBG positively influenced the level of transcription of several genes relevant to the immune system and overall health of the trout. The experimental findings indicated that UDBG: 1) modifies inflammatory responses, 2) makes responses more flexible and versatile, 3) protects from cellular stress, and 4) enhances “effector” mechanisms. Importantly, there was no evidence of immune system over-activity.
