Linear IgA bullous dermatosis (LABD) is a rare autoimmune vesiculobullous disorder characterized by variable clinical presentations that may mimic bullous pemphigoid, dermatitis herpetiformis, cicatricial pemphigoid a...Linear IgA bullous dermatosis (LABD) is a rare autoimmune vesiculobullous disorder characterized by variable clinical presentations that may mimic bullous pemphigoid, dermatitis herpetiformis, cicatricial pemphigoid and erythema multi- forme. A few cases of drug-induced LABD that clinically resembled toxic epidermal necrolysis (TEN) have been reported. A subset of patients with LABD have been found to be drug-induced: the most common drug being vancomycin. The diagnosisofLABDisconfirmedbythepresenceofalinearband of IgA along the basement membrane zone on direct immunofluorescence microscopy. We report a case of a 77- year-old man who presented to us with vancomycin-induced LABD that presented clinically as TEN, He had a complete recovery over a 3- week period following discontinuation of the vancomycin and the addition of oral dapsone therapy. It is important to be aware that drug-induced LABD can mimic TEN.展开更多
文摘Linear IgA bullous dermatosis (LABD) is a rare autoimmune vesiculobullous disorder characterized by variable clinical presentations that may mimic bullous pemphigoid, dermatitis herpetiformis, cicatricial pemphigoid and erythema multi- forme. A few cases of drug-induced LABD that clinically resembled toxic epidermal necrolysis (TEN) have been reported. A subset of patients with LABD have been found to be drug-induced: the most common drug being vancomycin. The diagnosisofLABDisconfirmedbythepresenceofalinearband of IgA along the basement membrane zone on direct immunofluorescence microscopy. We report a case of a 77- year-old man who presented to us with vancomycin-induced LABD that presented clinically as TEN, He had a complete recovery over a 3- week period following discontinuation of the vancomycin and the addition of oral dapsone therapy. It is important to be aware that drug-induced LABD can mimic TEN.
