激光改性YAG/YSZ双陶瓷热障涂层的高温氧化与TGO生长行为

以Inconel738合金为基体、NiCoCrAlY为黏接层,采用大气等离子喷涂(APS)技术制备YAG/YSZ双陶瓷热障涂层(TBC),并对YAG层表面进行激光改性,以提高TBC的抗高温氧化性能。通过恒温氧化实验研究喷涂态(AS)与激光改性(LM)TBC的高温氧化及热生长氧化物(TGO)的生长行为。结果表明,AS-TBC与LM-TBC的TGO厚度与结构呈现相似变化趋势,即厚度随氧化时间增加而增加,结构则均由单一Al_(2)O_(3)层演变为混合氧化物层在上、Al_(2)O_(3)层在下的双层形貌。基于激光改性对氧气渗透的强烈抑制作用,LM-TBC中混合氧化物出现的时间推迟,在氧化中后期LM-TBC的总体TGO厚度也有所减少。经过相同的氧化时间,LM-TBC中Al_(2)O_(3)厚度在总体TGO厚度中占比始终大于或等于AS-TBC,并且LM-TBC的抛物线氧化速率相比AS-TBC下降了18.42%。因此,YAG/YSZ LM-TBC呈现更优异的高温抗氧化性能与更低的TGO生长速率。

Calycosin attenuates severe acute pancreatitis-associated acute lung injury by curtailing high mobility group box 1-induced inflammation

BACKGROUND Acute lung injury(ALI)is a common and life-threatening complication of severe acute pancreatitis(SAP).There are currently limited effective treatment options for SAP and associated ALI.Calycosin(Cal),a bioactive constituent extracted from the medicinal herb Radix Astragali exhibits potent anti-inflammatory properties,but its effect on SAP and associated ALI has yet to be determined.AIM To identify the roles of Cal in SAP-ALI and the underlying mechanism.METHODS SAP was induced via two intraperitoneal injections of L-arg(4 g/kg)and Cal(25 or 50 mg/kg)were injected 1 h prior to the first L-arg challenge.Mice were sacrificed 72 h after the induction of SAP and associated ALI was examined histologically and biochemically.An in vitro model of lipopolysaccharide(LPS)-induced ALI was established using A549 cells.Immunofluorescence analysis and western blot were evaluated in cells.Molecular docking analyses were conducted to examine the interaction of Cal with HMGB1.RESULTS Cal treatment substantially reduced the serum amylase levels and alleviated histopathological injury associated with SAP and ALI.Neutrophil infiltration and lung tissue levels of neutrophil mediator myeloperoxidase were reduced in line with protective effects of Cal against ALI in SAP.Cal treatment also attenuated the serum levels and mRNA expression of pro-inflammatory cytokines tumor necrosis factor-α,interleukin-6,IL-1β,HMGB1 and chemokine(CXC motif)ligand 1 in lung tissue.Immunofluorescence and western blot analyses showed that Cal treatment markedly suppressed the expression of HMGB1 and phosphorylated nuclear factor-kappa B(NF-κB)p65 in lung tissues and an in vitro model of LPSinduced ALI in A549 cells suggesting a role for HGMB1 in the pathogenesis of ALI.Furthermore,molecular docking analysis provided evidence for the direct interaction of Cal with HGMB1.CONCLUSION Cal protects mice against L-arg-induced SAP and associated ALI by attenuating local and systemic neutrophil infiltration and inflammatory response via inhibition of HGMB1 and the NF-κB signaling pathway.

The Matrix Stiffness and Physical Confinement of Hydrogel Microchannel Jointly Induce the Mesenchymal-Amoeboid Transition for Cancer Cell Migration

The migration mode transition of cancer cell enhances its invasive capability and the drug resistance,where physical confinement of cell microenvironment has been revealed to induce the mesenchymal-amoeboid transition(MAT).However,most existing studies are performed in PDMS microchannels,of which the stiffness is much higher than that of most mammalian tissues.Therefore,the amoeboid migration transition observed in these studies is actually induced by the synergistic effect of matrix stiffness and confinement.Since the stiffness of cell microenvironment has been reported to influence the cell migration in 2D substrate,the decoupling of stiffness and confinement effects is thus in need for elucidating the underlying mechanism of MAT.However,it is technically challenging to construct microchannels with physiologically relevant stiffness and channel size,where existing microchannel platforms with physiological relevance stiffness are all with>10μm channel width.Such size is too wide to mimic the physical confinement that migrating cancer cells confront in vivo,and also larger than the width of PDMS channel,in which the MAT of cancer cell was observed.Therefore,an in vitro cell migration platform,which could mimic both stiffness and confinement of the native physical microenvironment during cancer metastasis,could profoundly contribute to researches on cancer cell migration and cellular mechanotransduction.In this paper,we overcome the limitations of engineering soft materials in microscale by combining the collagen-alginate hydrogel with photolithography.This enables us to improve the accuracy of molded microchannel,and thus successfully construct a 3D microchannel platform,which matches the stiffness and width ranges of native environmental confinement that migrating cancer cells confront in vivo.The stiffness(0.3~20 kPa),confinement(channel width:3.5~14μm)and the adhesion ligand density of the microchannel can be tuned independently.Interestingly,using this platform,we observed that the migration speed of cancer cell is influenced by the synergistic effect of channel stiffness and width,and the increasing stiffness reverses the effect of channel width on the migration speed of cancer cells.In addition,MAT has a strong correlation with the channel stiffness.These findings make us reconsider the widely accepted hypothesis:physical confinement can induce MAT.Actually,this transition can only occur in stiff confined microenvironment not in soft one.For soft microchannels,the compliance of the channel walls could cause little cell/nucleus deformation,and the MAT could not be induced.To further investigate the mechanism of MAT,we developed a computational model to simulate the effect of nucleus deformation on MAT.With the model,we found that deforming the cell nuclear by decreasing the nucleus stiffness will reduce the cellmigration speed.This implies that nuclear stiffness plays an important role in the regulation of cancer migration speed and thus MAT in microchannels.The effect of channel stiffness on MAT and migration speed as observed in our experiment could partially explain previous findings reported in the literature,where the increasing matrix stiffness of tumor microenvironment promotes cancer metastasis.Our observations thus highlight the critical role of cell nuclear deformation not only in MAT,but also in regulating cellular mechanotransduction and cell-ECM interactions.This developed platform is capable of mimicking the native physical microenvironment during metastasis,providing a powerful tool for high-throughput screening applications and investigating the interaction between cancer migration and biophysical microenvironment.

Enhancing Collaborative Filtering via Topic Model Integrated Uniform Euclidean Distance

Recommendation system can greatly alleviate the "information overload" in the big data era. Existing recommendation methods, however, typically focus on predicting missing rating values via analyzing user-item dualistic relationship, which neglect an important fact that the latent interests of users can influence their rating behaviors. Moreover, traditional recommendation methods easily suffer from the high dimensional problem and cold-start problem. To address these challenges, in this paper, we propose a PBUED(PLSA-Based Uniform Euclidean Distance) scheme, which utilizes topic model and uniform Euclidean distance to recommend the suitable items for users. The solution first employs probabilistic latent semantic analysis(PLSA) to extract users' interests, users with different interests are divided into different subgroups. Then, the uniform Euclidean distance is adopted to compute the users' similarity in the same interest subset; finally, the missing rating values of data are predicted via aggregating similar neighbors' ratings. We evaluate PBUED on two datasets and experimental results show PBUED can lead to better predicting performance and ranking performance than other approaches.

A three-band perfect absorber based on a parallelogram metamaterial slab with monolayer MoS_(2)

As a two-dimensional(2D)material,monolayer MoS2which limits its optical applications has a low absorption efficiency.In this paper,we propose a three-band perfect metamaterial absorber in the visible light range based on monolayer MoS_(2).The peak absorptivity of the structure at each resonance wavelength is nearly perfect,moreover,the light absorption of monolayer MoS2is obviously enhanced at the three resonant wavelengths.The dielectric–dielectric–metal structure we designed produces the coupling of Fabry–Perot resonance and high-order diffraction guided-mode resonance at different absorption peaks,which has been proved by the slab waveguide theory.In addition,the multi-modal absorption phenomenon is explained by extracting the equivalent impedance.The results show that we can adjust the absorption peak wavelength by regulating the parameters of the structure.This structure not only provides an idea for enhancing the interaction between light and two-dimensional materials but also has potential applications for optical detection devices.

不动产登记存量数据整合的方法研究与实现

存量数据整理是不动产登记发证的基础工作,本文结合沈阳市不动产登记数据整合项目,设计了登记发证的技术流程与数据整理方法,以宗地为整理单元,通过房地协同整理、内外业结合的方法,进行土地数据整理、房产数据整理、房地数据编码入库等工作,完成了该市不动产存量数据整理工作,对其他城市的同类工作具有借鉴意义。

国土资源巡查监管系统设计与实现

为加强国土空间资源监管的信息化建设,完善自然资源执法监督业务流程,建立了综合业务管理与移动应用一体化的系统,采用Activiti+GIS耦合的技术,实现了地理资源可视化、巡查任务下发管理、移动应用数据采集等功能,提高了国土资源巡查工作的质量与效率。

激光填丝焊接镍基合金/304不锈钢二次相的转变机制及其对晶间腐蚀性能的影响

为了阐明激光填丝焊接镍基合金(Hastelloy C-276)/304二次相的转变机制和晶间腐蚀机制,通过EPMA和TEM对二次相进行分析;采用双环动电位再活化法(DL-EPR)对焊接接头的晶间腐蚀性能进行评价,并采用EDS对焊接接头腐蚀表面进行成分分析。实验结果表明:p相和μ相为完全共格关系,且其共格关系为[001]p//■和[430]p//[0001]μ。μ相由p相快速相转变而成,此相变过程为不均匀相变。二次相转变将增大晶间腐蚀敏感性。因此,在焊接过程中应该避免这种相变。

基于ArcGIS的影像数据坐标系转换与影像服务裁切功能的实现

针对工程实践中影像数据坐标系转换以及线上裁切的需求,基于对坐标系转换模型的理论研究和影像数据线上裁切方法的深入探索,采用平面四参数模型对影像数据进行平面坐标系转换,采用ArcGIS Server SOE技术对影像服务进行扩展开发的方法满足影像数据线上裁切需求,利用Arc Map 10.1作为数据处理平台,成功对沈阳市2013、2015和2017年的影像数据实现平面坐标系向CGCS2000的转换,利用Visual Studio 2010和ArcGIS10.1作为开发平台,扩展开发影像服务的功能接口,实现了影像数据的在线裁切。

基于Auto CAD.NET API的DWG文件坐标变换的研究及实现

针对工程实践中不同坐标系下DWG数据相互变换的实际需要,通过对DWG数据存储组织结构以及AutoCAD.NET API的深入研究,采用平面四参数转换方法,基于Visual Studio 2010和AutoCAD 2008开发平台,成功开发了DWG数据坐标变换程序。以沈阳市1∶500比例尺、1954北京坐标系的DWG数据为例,实现了不同坐标系下DWG数据的互相变换,并对变换后的数据进行了要素检查和精度分析。结果证明,采用基于AutoCAD.NET API二次开发的技术能够很好地满足DWG数据在不同坐标系下互相变换的应用需求,大大地节省了工作时间,提高了工作效率。

Advances in lung cancer screening and early detection

Lung cancer is associated with a heavy cancer-related burden in terms of patients’physical and mental health worldwide.Two randomized controlled trials,the US-National Lung Screening Trial(NLST)and Nederlands-Leuvens Longkanker Screenings Onderzoek(NELSON),indicated that low-dose CT(LDCT)screening results in a statistically significant decrease in mortality in patients with lung cancer,LDCT has become the standard approach for lung cancer screening.However,many issues in lung cancer screening remain unresolved,such as the screening criteria,high false-positive rate,and radiation exposure.This review first summarizes recent studies on lung cancer screening from the US,Europe,and Asia,and discusses risk-based selection for screening and the related issues.Second,an overview of novel techniques for the differential diagnosis of pulmonary nodules,including artificial intelligence and molecular biomarker-based screening,is presented.Third,current explorations of strategies for suspected malignancy are summarized.Overall,this review aims to help clinicians understand recent progress in lung cancer screening and alleviate the burden of lung cancer.

Selective tropism of liver stem cells to hepatocellular carcinoma in vivo

AIM: To investigate the selective tropism of liver stem cells to hepatocellular carcinoma (HCC) in an animal model and its feasibility as a vector to deliver therapeutic genes for targeted therapy of HCC. METHODS: WB-F344, a kind of rat liver stem cell, was infected with recombinant virus to establish a cell line with stable, high-level expressing enhanced green fluorescent protein (EGFP). An animal model of HCC in Wistar rats was established by implanting HCC cells (CBRH7919) combined with an immunosuppressive drug. EGFP labeled liver stem cells were injected into caudal veins of the animals and distribution was observed at different time points after injection. SDF-1 and c-kit expression in non-tumor liver and tumor tissue were analysed by immunohistochemistry for the relationshiop between the expression and migration of liver stem cells. Furthermore, hepatic stem cells were injected via the portal vein, hepatic artery, caudal vein, or directly into the pericancerous liver tissue, respectively, and effects on migration, localization, and proliferation of the hepatic stem cells within the tumor tissue were observed and analyzed. RESULTS: Recombinant adenovirus could deliver the EGFP gene to hepatic stem cells. A new stem cell line, named WB-EGFP, was established that stably expressed EGFP. WB-EGFP cells still showed selective tropism towards HCC and EGFP expression was stable in vivo. According to immunohistochemistry results, SDF-1 may not be related to the mechanisms of tropism of hepatic stem cells. Different application sites affected the distribution of liver stem cells. Injection via the portalvein was superior with regard to selective migration, localization, and proliferation of the hepatic stem cells within the tumor tissue. CONCLUSION: Liver stem cells have the biological behavior of selective migration to HCC in vivo and they could localize and proliferate within HCC tissue stably expressing the target gene. Liver stem cells are a potential tool for a targeted gene therapy of HCC.

基于相间交联的共混型宽温域阻尼弹性体的制备及机理

结合过氧化物硫化体系的硫化过程,提出过氧化二苯甲酰(BPO)可以引发环氧化天然橡胶(ENR)与邻苯二甲酸二烯丙酯预聚体(DAP-A)发生相间交联反应,以改善两相之间的相容性,拓宽ENR/DAP-A二元共混材料的有效阻尼温域。分别采用硫磺硫化体系和BPO硫化体系制备的ENR-40(环氧化程度为40%的ENR/DAP-A二元共混材料)进行对比分析,并利用动态力学分析、差示扫描量热分析以及宽频介电谱论证了上述机理。基于以上机理,进一步探究了共混比例和BPO用量对ENR-40/DAP-A二元共混材料阻尼性能的影响,最终制备了一种有效阻尼温域为-33~145℃(tanδmin>0.35)的宽温域高阻尼材料。

Serum soluble suppression of tumorigenicity 2 as a novel inflammatory marker predicts the severity of acute pancreatitis

BACKGROUND Acute pancreatitis(AP)is an inflammatory disease in which the regulatory pathway is complex and not well understood.Soluble suppression of tumorigenicity 2(sST2)protein receptor functions as a decoy receptor for interleukin(IL)-33 to prevent IL-33/suppression of tumorigenicity 2L(ST2L)-pathwaymediated T helper(Th)2 immune responses.AIM To investigate the role of sST2 in AP.METHODS We assessed the association between sST2 and severity of AP in 123 patients enrolled in this study.The serum levels of sST2,C-reactive protein(CRP)and Th1-and Th2-related cytokines,including interferon(IFN)-γ,tumor necrosis factor(TNF)-α,IL-2,IL-4,IL-5 and IL-13,were measured by highly sensitive ELISA,and the severity of AP in patients was evaluated by the 2012 Atlanta Classification Criteria.RESULTS Serum sST2 levels were significantly increased in AP patients,and further,these levels were significantly elevated in severe AP(SAP)patients compared to moderately severe AP(MSAP)and mild AP(MAP)patients.Logistic regression showed sST2 was a predictor of SAP[odds ratio(OR):1.003(1.001–1.006),P=0.000].sST2 cutoff point was 1190 pg/mL,and sST2 above this cutoff was associated with SAP.sST2 was also a predictor of any organ failure and mortality during AP[OR:1.006(1.003–1.009),P=0.000,OR:1.002(1.001–1.004),P=0.012,respectively].Additionally,the Th1-related cytokines IFN-γand TNF-αin the SAP group were higher and the Th2-related cytokine IL-4 in the SAP group was significantly lower than those in MSAP and MAP groups.CONCLUSION sST2 may be used as a novel inflammatory marker in predicting AP severity and may regulate the function and differentiation of IL-33/ST2-mediated Th1 and Th2 Lymphocytes in AP homeostasis.

Stability analysis of backflling in subsiding area and optimization of the stoping sequence

In underground mining by sublevel caving method, the deformation and damage of the surface induced by subsidence are the major challenging issues. The dynamic and soft backflling body increases the safety risks in the subsiding area. In this paper, taking Zhangfushan iron mine as an example, the ore body and the general layout are focused on the safety of backflling of mined-out area. Then, we use the ANSYS software to construct a three-dimensional(3D) model for the mining area in the Zhangfushan iron mine. According to the simulation results of the initial mining stages, the ore body is stoped step by step as suggested in the design. The stability of the backflling is back analyzed based on the monitored displacements, considering the stress distribution to optimize the stoping sequence. The simulations show that a reasonable stoping sequence can minimize the concentration of high compressive stress and ensure the safety of stoping of the ore body.

MobiGemini:Sensitive-Based Data and Resource Protection Framework for Mobile Device

With the popularity of smartphones and the rapid development of mobile internet, smartphone becomes an important tool that store sensitive data of owner. Encryption naturally becomes a necessary means of protection. In certain situations, this is inadequate, as user may be coerced to hand over decryption keys or passwords of sensitive APP(Ali Pay) on mobile device. Therefore, only encryption cannot protect sensitive APP and privacy data stored on user's smartphone. To address these obstacles, we design a protection system called Mobi Gemini. It enables automatic uninstalling service that can immediately uninstall multiple APP at same time, and also enabling plausibly deniable encryption(PDE) on mobile devices by hiding encrypted volume within random data in free space of cache partition. We improve the key store way of previous PDE schemes on mobile device. The evaluation results show that the scheme introduces a few overhead compared with original android system enabling full disk encryption.

Lightweight SOA-Based Twin-Engine Architecture for Enterprise Systems in Fixed and Mobile Environments

Mobile devices as a popular computing platform for enterprise systems have enabled certain tasks to be executed out of office.However,the work may be interrupted due to the server shutdown or network disconnection when employees access traditional single-engine Business Process Management System.To overcome this defect,we present a lightweight twin-engine architecture based on Service Oriented Architecture(SOA).In this paper,we discuss in detail the design and implementation of the architecture,and present a trigger mechanism to activate engines according to the states of hybrid environments since it is critical for the two types of engines to cooperate closely in hybrid environments with fixed and mobile computing resources.The experimental results validate the usability of the architecture.

Microstructure and texture evolution of Mg–3Zn–1Al magnesium alloy during large-strain electroplastic rolling

Large-strain deformation by single electroplastic rolling （EPR） was imposed on AZ31 magnesium alloy strips. During EPR at low temperature （150-250℃）, numerous twins formed in the alloy. After EPR at a high temperature （350℃）, the number of twins reduced and some dynamic recrystallization （DRX） grains formed at grain boundaries and twinned regions. The synergic thermal and athermal effects generated by electropulsing, which promoted dislocation motion, induced a few small DRX grains, and ductile bandings were mainly re- sponsible for large-strain deformation during EPR. The inclination angle of the basal pole stemmed from the counterbalance of the inclina- tion direction of the basal pole between the DRX grains and deformed coarse grains.

A large basal cell adenoma extending to the ipsilateral skull base and mastoid in the right parotid gland: A case report

BACKGROUND Basal cell adenoma (BCA) is a rare benign tumour that has unique histological characteristics and primarily arises in the parotid glands. According to published reports, nearby tissue destruction by BCA seems impossible. CASE SUMMARY We presented a case of a 54-year-old woman with a mass in the deep lobe of the right parotid gland involving the ipsilateral skull base and mastoid. The patient exhibited gradual right facial swelling but no other obvious symptoms. Combined resection of the total right parotid gland and partial skull base excision were performed. The biopsy conducted before the surgery and sections cut from intraoperatively obtained tissues were not definitive for identifying the character of the neoplasm. A final diagnosis of tubular BCA without malignant elements was established based on postoperative pathology results and immunohistochemical analysis. The tumour did not recur during the 12-mo follow-up period. CONCLUSION A diagnosis of BCA can only be established based on a histopathological examination after an excisional biopsy, and tubular BCA should carefully be considered as a destructive type.

Proactive Personalized Services Through Fog-Cloud Computing in Large-Scale IoT-Based Healthcare Application

With the development of medical sensors and IoT, personalized service assisted elder and patient living is a critical service in IoT-based healthcare application. However, the scale and complexity of personalized service is increasing because of ubiquitous deployment of various kinds of medical sensors, which cause response time increase and resource waste. Therefore, leveraging the advantage of complex event processing(CEP) in data stream processing, we propose a hierarchical fog-cloud computing CEP architecture for personalized service to accelerate response time and reduce resource waste. Firstly, we introduce the proposed architecture, which includes sensor layer, fog layer and cloud layer. Secondly, we propose a series of optimizations for the architecture, there are a partitioning and clustering approach and a communication and parallel processing policy to optimize the fog and cloud computing. Finally, we implement a prototype system based on the architecture named Fog Cep Care. Experimental result shows that Fog Cep Care is superior to the traditional IoT-based healthcare application.