Amino acids are the building blocks of protein synthesis.They are structural elements and energy sources of cells necessary for normal cell growth,differentiation and function.Amino acid metabolism disorders have been...Amino acids are the building blocks of protein synthesis.They are structural elements and energy sources of cells necessary for normal cell growth,differentiation and function.Amino acid metabolism disorders have been linked with a number of pathological conditions,including metabolic diseases,cardiovascular diseases,immune diseases,and cancer.In the case of tumors,alterations in amino acid metabolism can be used not only as clinical indicators of cancer progression but also as therapeutic strategies.展开更多
Nowadays, application systems in pervasive computing have to be self-adaptive, which means adapting themselves to dynamic environments. Our aim is to enable systematic development of self-adaptive compo-nent-based app...Nowadays, application systems in pervasive computing have to be self-adaptive, which means adapting themselves to dynamic environments. Our aim is to enable systematic development of self-adaptive compo-nent-based applications. The paper first introduces a novel policy based framework for self-adaptive scheme in pervasive computing. Then the proposed policy ontology and policy language are well expressive and eas-ily extensible to support the design of policy which is based on the Separation of Concerns principle. Fur-thermore, the context-driven event channel decouples the communication between the suppliers and con-sumers for asynchronous communication. The proposed framework can provide both a domain-independent and a flexible self-adaptation solution.展开更多
Rice blast, caused by the fungal pathogen Magnaporthe oryzae, is one of the most destructive diseases of rice worldwide. The rice-M, oryzae pathosystem has become a model in the study of plant-fungal interactions beca...Rice blast, caused by the fungal pathogen Magnaporthe oryzae, is one of the most destructive diseases of rice worldwide. The rice-M, oryzae pathosystem has become a model in the study of plant-fungal interactions because of its scientific advancement and economic importance. Recent studies have identified a number of new pathogen- associated molecular patterns （PAMPs） and effectors from the blast fungus that trigger rice immune responses upon perception. Interaction analyses between avirulence effectors and their cognate resistance proteins have provided new insights into the molecular basis of plant-fungal interactions. In this review, we summarize the recent research on the characterization of those genes in both M. oryzae and rice that are important for the PAMP- and effector-triggered immunity recognition and signaling processes. We also discuss future directions for research that will further our understanding of this pathosystem.展开更多
Three new chromone derivatives, phomochromenones A-C （1-3）, and one known chaetocyclinone B （4） were obtained from the cultures ofPhomopsis sp. HNY29-2B isolated from the mangrove Acanthus ilicifolius Linn., which...Three new chromone derivatives, phomochromenones A-C （1-3）, and one known chaetocyclinone B （4） were obtained from the cultures ofPhomopsis sp. HNY29-2B isolated from the mangrove Acanthus ilicifolius Linn., which was collected from the South China Sea. Their structures were determined by the analysis of 1D NMR and 2D NMR as well as mass spectroscopic data. The absolute configurations of I and 2 were assigned by quantum chemi- cal calculations of the electronic circular dichroism （ECD） spectra. Compound 3 is the third example of alkaloids possessing the unique chromeno [3,2-c] pyridine nucleus. In the bioactivity assay, compound 4 showed cytotoxicity against human prostate cancer cell lines （PC-3 and DU145 cells） with the IC50 values of 8.13 and 3.59 μmol/L, respectively.展开更多
Network virtualization is recognized as an effective way to overcome the ossification of the Internet. However, the virtual network mapping problem (VNMP) is a critical challenge, focusing on how to map the virtual ne...Network virtualization is recognized as an effective way to overcome the ossification of the Internet. However, the virtual network mapping problem (VNMP) is a critical challenge, focusing on how to map the virtual networks to the substrate network with efficient utilization of infrastructure resources. The problem can be divided into two phases: node mapping phase and link mapping phase. In the node mapping phase, the existing algorithms usually map those virtual nodes with a complete greedy strategy, without considering the topology among these virtual nodes, resulting in too long substrate paths (with multiple hops). Addressing this problem, we propose a topology awareness mapping algorithm, which considers the topology among these virtual nodes. In the link mapping phase, the new algorithm adopts the k-shortest path algorithm. Simulation results show that the new algorithm greatly increases the long-term average revenue, the acceptance ratio, and the long-term revenue-to-cost ratio (R/C).展开更多
Chloroplasts most likely originated from the endosymbiosis of cyanobacterial ancestors,entering the eukaryotic lineage about 1.0-1.5 billion years ago(Parfrey et al.,2011;Archibald,2015).Consequently,their biogenesis ...Chloroplasts most likely originated from the endosymbiosis of cyanobacterial ancestors,entering the eukaryotic lineage about 1.0-1.5 billion years ago(Parfrey et al.,2011;Archibald,2015).Consequently,their biogenesis depends on genetic information from both the nuclear and chloroplast genomes.Photosynthetic housekeeping genes of core components in photosystemsⅠandⅡ(PSI and PSII)are encoded by the plastid genome。展开更多
Histone lysine methylation is known to be involved in the epigenetic regulation of gene expression in all eukaryotes including plants. Here we show that the rice SDG714 is primarily responsible for dimethylation but n...Histone lysine methylation is known to be involved in the epigenetic regulation of gene expression in all eukaryotes including plants. Here we show that the rice SDG714 is primarily responsible for dimethylation but not trimethylaUon on histone H3K9 in vivo. Overexpression of YFP-SDG714 in Arabidopsis significantly inhibits plant growth and this inhibition is associated with an enhanced level of H3K9 dimethylation. Our microarray results show that many genes essential for the plant growth and development were downregulated in transgenic Arabidopsis plants overexpressing YFP-SDG714. By chromatin immunoprecipitation analysis, we show that YFP-SDG714 is targeted to specific chromatin regions and dimethylate the H3Kg, which is linked with heterochromatinization and the downregulation of genes. Most interestingly, when YFP-SDG714 production is stopped, the inhibited plants can partially restore their growth, suggesting that the perturbation of gene expression caused by YFP-SDG714 is revertible. Taken together, our results point to an important role of SDG714 in H3K9 dimethylation, suppression of gene expression and plant growth, and provide a potential method to regulate gene expression and plant development by an on-off switch of SDG714 expression.展开更多
Lithium batteries(LIBs) with low capacity graphite anode(~372 mAh g-1) cannot meet the ever-growing demand for new energy electric vehicles and renewable energy storage.It is essential to replace graphite anode with h...Lithium batteries(LIBs) with low capacity graphite anode(~372 mAh g-1) cannot meet the ever-growing demand for new energy electric vehicles and renewable energy storage.It is essential to replace graphite anode with higher capacity anode materials for high-energy density LIBs.Silicon(Si) is well known to be a possible alternative for graphite anode due to its highest capacity(~4200 mAh g-1).Unfortunately,large volume change during lithiation and delithiation has prevented the Si anode from being commercialized.Metal silicides are a promising type of anode materials which can improve cycling stability via the accommodation of volume change by dispersing Si in the metal inactive/active matrix,while maintain greater capacity than graphite.Here,we present a classification of Si alloying with metals in periodic table of elements,review the available literature on metal silicide anodes to outline the progress in improving and understanding the electrochemical performance of various metal silicides,analyze the challenges that remain in using metal silicides,and offer perspectives regarding their future research and development as anode materials for commercial LIBs application.展开更多
基金The National Natural Science Foundation of China(82073144,J.W.)the Health Commission of Zhejiang Province(JBZX-202004,J.W.)the Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China(LHDMD22H310005,J.W.).
文摘Amino acids are the building blocks of protein synthesis.They are structural elements and energy sources of cells necessary for normal cell growth,differentiation and function.Amino acid metabolism disorders have been linked with a number of pathological conditions,including metabolic diseases,cardiovascular diseases,immune diseases,and cancer.In the case of tumors,alterations in amino acid metabolism can be used not only as clinical indicators of cancer progression but also as therapeutic strategies.
文摘Nowadays, application systems in pervasive computing have to be self-adaptive, which means adapting themselves to dynamic environments. Our aim is to enable systematic development of self-adaptive compo-nent-based applications. The paper first introduces a novel policy based framework for self-adaptive scheme in pervasive computing. Then the proposed policy ontology and policy language are well expressive and eas-ily extensible to support the design of policy which is based on the Separation of Concerns principle. Fur-thermore, the context-driven event channel decouples the communication between the suppliers and con-sumers for asynchronous communication. The proposed framework can provide both a domain-independent and a flexible self-adaptation solution.
基金This work was supported by the US NSF-IOS to G.L.W. （1120949）the National Natural Science Foundation of China to W.D.L. （31272034）+3 种基金 Y.S.N. （31101405） and X.L.W. （31101404） the 973 Project （2012CBl14005） of Ministry of Science and Technology China and the National Transgenic Crop Initiative to G.L.W. （2012ZX08009001） and the Scientific and Technological Innovation Program of Hunan Universities from Hunan Department of Science and Technology and the Program for Innovative Research Team in University from Ministry of Education in China IRT1239） to Z.L.W. No conflict of interest declared.
文摘Rice blast, caused by the fungal pathogen Magnaporthe oryzae, is one of the most destructive diseases of rice worldwide. The rice-M, oryzae pathosystem has become a model in the study of plant-fungal interactions because of its scientific advancement and economic importance. Recent studies have identified a number of new pathogen- associated molecular patterns （PAMPs） and effectors from the blast fungus that trigger rice immune responses upon perception. Interaction analyses between avirulence effectors and their cognate resistance proteins have provided new insights into the molecular basis of plant-fungal interactions. In this review, we summarize the recent research on the characterization of those genes in both M. oryzae and rice that are important for the PAMP- and effector-triggered immunity recognition and signaling processes. We also discuss future directions for research that will further our understanding of this pathosystem.
基金Supporting information for this article is available on the WWW under http：//dx.doi.org/10.1002/cjoc.201700375 or from the author.Acknowledgement We thank the National Natural Science Foundation of China （Nos. 21472251, 41276146）, the Key Project of Natural Science Foundation of Guangdong Province （No. 2016A030311026）, the Science ＆ Technology Plan Project of Guangdong Province of China （Nos. 2013B021100011, 2016A040403091）, the Special Financial Fund of Innovative Development of Marine Economic Demonstration Project （No. GD2012-D01- 001）, the China＇s Marine Commonweal Research Project （No. 201305017）, the Guangzhou Project of Science ＆ Technology Planning （No. 201300000062）, the Fundamental Research Funds for the Central Universities （No. 141gjc16） and the Supercomputing Center of Chinese Academy of Sciences （SCCAS） for generous support.
文摘Three new chromone derivatives, phomochromenones A-C （1-3）, and one known chaetocyclinone B （4） were obtained from the cultures ofPhomopsis sp. HNY29-2B isolated from the mangrove Acanthus ilicifolius Linn., which was collected from the South China Sea. Their structures were determined by the analysis of 1D NMR and 2D NMR as well as mass spectroscopic data. The absolute configurations of I and 2 were assigned by quantum chemi- cal calculations of the electronic circular dichroism （ECD） spectra. Compound 3 is the third example of alkaloids possessing the unique chromeno [3,2-c] pyridine nucleus. In the bioactivity assay, compound 4 showed cytotoxicity against human prostate cancer cell lines （PC-3 and DU145 cells） with the IC50 values of 8.13 and 3.59 μmol/L, respectively.
基金supported by the National Basic Research Program (973) of China (No. 2011CB302601)the National Natural Science Foundation of China (No. 90818028)the National High-Tech R&D Program (863) of China (No. 2007AA010301)
文摘Network virtualization is recognized as an effective way to overcome the ossification of the Internet. However, the virtual network mapping problem (VNMP) is a critical challenge, focusing on how to map the virtual networks to the substrate network with efficient utilization of infrastructure resources. The problem can be divided into two phases: node mapping phase and link mapping phase. In the node mapping phase, the existing algorithms usually map those virtual nodes with a complete greedy strategy, without considering the topology among these virtual nodes, resulting in too long substrate paths (with multiple hops). Addressing this problem, we propose a topology awareness mapping algorithm, which considers the topology among these virtual nodes. In the link mapping phase, the new algorithm adopts the k-shortest path algorithm. Simulation results show that the new algorithm greatly increases the long-term average revenue, the acceptance ratio, and the long-term revenue-to-cost ratio (R/C).
基金supported by the National Natural Science Foundation of China(31671336 and 31972958)the Start-Up Funds for High Level Talents of Qingdao Agricultural University(663-1120001)the First Class Grassland Science Discipline Program of Shandong Province,China。
文摘Chloroplasts most likely originated from the endosymbiosis of cyanobacterial ancestors,entering the eukaryotic lineage about 1.0-1.5 billion years ago(Parfrey et al.,2011;Archibald,2015).Consequently,their biogenesis depends on genetic information from both the nuclear and chloroplast genomes.Photosynthetic housekeeping genes of core components in photosystemsⅠandⅡ(PSI and PSII)are encoded by the plastid genome。
基金supported by the National Natural Science Foundation of China (30800629 and 30628004)the National Talent Training Fund in Basic Research of China (J0630643)+2 种基金Shanghai Educational Development Foundation (2007CG06)the Specialized Research Fund for the Doctoral Program of Higher Education (for the New Teachers)supported by the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry
文摘Histone lysine methylation is known to be involved in the epigenetic regulation of gene expression in all eukaryotes including plants. Here we show that the rice SDG714 is primarily responsible for dimethylation but not trimethylaUon on histone H3K9 in vivo. Overexpression of YFP-SDG714 in Arabidopsis significantly inhibits plant growth and this inhibition is associated with an enhanced level of H3K9 dimethylation. Our microarray results show that many genes essential for the plant growth and development were downregulated in transgenic Arabidopsis plants overexpressing YFP-SDG714. By chromatin immunoprecipitation analysis, we show that YFP-SDG714 is targeted to specific chromatin regions and dimethylate the H3Kg, which is linked with heterochromatinization and the downregulation of genes. Most interestingly, when YFP-SDG714 production is stopped, the inhibited plants can partially restore their growth, suggesting that the perturbation of gene expression caused by YFP-SDG714 is revertible. Taken together, our results point to an important role of SDG714 in H3K9 dimethylation, suppression of gene expression and plant growth, and provide a potential method to regulate gene expression and plant development by an on-off switch of SDG714 expression.
基金financially supported by the School-Enterprise cooperation Project(RD18200058)the Anhui Natural Science Foundation(No.1908085ME151)+2 种基金the Anhui province high-end talent Grant(DT18100044)the Key Laboratory of Marine Materials and Related Technologies,CAS(2019K07)the National Foreign Expert Introduction Plan Project(G20190219004)。
文摘Lithium batteries(LIBs) with low capacity graphite anode(~372 mAh g-1) cannot meet the ever-growing demand for new energy electric vehicles and renewable energy storage.It is essential to replace graphite anode with higher capacity anode materials for high-energy density LIBs.Silicon(Si) is well known to be a possible alternative for graphite anode due to its highest capacity(~4200 mAh g-1).Unfortunately,large volume change during lithiation and delithiation has prevented the Si anode from being commercialized.Metal silicides are a promising type of anode materials which can improve cycling stability via the accommodation of volume change by dispersing Si in the metal inactive/active matrix,while maintain greater capacity than graphite.Here,we present a classification of Si alloying with metals in periodic table of elements,review the available literature on metal silicide anodes to outline the progress in improving and understanding the electrochemical performance of various metal silicides,analyze the challenges that remain in using metal silicides,and offer perspectives regarding their future research and development as anode materials for commercial LIBs application.
