The formation, characterization, and purification of well-defined stoichiometric clusters of metallic nanoparticles, particularly in the form of dimers or trimers, are important and formidable challenges in nanoscienc...The formation, characterization, and purification of well-defined stoichiometric clusters of metallic nanoparticles, particularly in the form of dimers or trimers, are important and formidable challenges in nanoscience. Here we show that flow cytometry can be used as a high-throughput method to determine the relative distribution of oligomeric clusters of molecularly linked gold nano- particles in bulk solution at the single-particle level with good statistics. This unique information would be near impossible to obtain using traditional characterization techniques. The flow cytometric approach is utilized to provide fast feedback for the synthesis optimization of the complex reaction between citrate-stabilized gold nanoparticles and bi-functional molecular wires with dithiocarbamate anchoring groups. Finally, we demonstrate that flow cytometry can be used to significantly increase the proportion of AuNP dimers from an oligomer-rich polydisperse sample by size-selective sorting.展开更多
Using diamine as anchoring group, the self-assembled monolayers（SAMs） based on oligo（phenyleneethynylene）s（OPEs） and cruciform OPEs with an extended tetrathiafulvalene（TTF）（OPE3 and OPE3-TTF）were successfull...Using diamine as anchoring group, the self-assembled monolayers（SAMs） based on oligo（phenyleneethynylene）s（OPEs） and cruciform OPEs with an extended tetrathiafulvalene（TTF）（OPE3 and OPE3-TTF）were successfully formed on the Au substrate. The Uniformity and stability of SAMs were confirmed through cyclic voltammetry（CV） and electrochemical reductive desorption. The investigation of transport properties of SAMs was achieved by conducting-probe atomic force microscopy（CP-AFM） with both Au and Pt tips. The results indicated that the conductance of OPE3-TTF was 17 and 46 times that of OPE3 for Au and Pt tips, respectively. Theoretical calculations are qualitatively consistent with the experimental results, suggesting that the diamine as anchoring group has a great potential in molecular electronics.展开更多
文摘The formation, characterization, and purification of well-defined stoichiometric clusters of metallic nanoparticles, particularly in the form of dimers or trimers, are important and formidable challenges in nanoscience. Here we show that flow cytometry can be used as a high-throughput method to determine the relative distribution of oligomeric clusters of molecularly linked gold nano- particles in bulk solution at the single-particle level with good statistics. This unique information would be near impossible to obtain using traditional characterization techniques. The flow cytometric approach is utilized to provide fast feedback for the synthesis optimization of the complex reaction between citrate-stabilized gold nanoparticles and bi-functional molecular wires with dithiocarbamate anchoring groups. Finally, we demonstrate that flow cytometry can be used to significantly increase the proportion of AuNP dimers from an oligomer-rich polydisperse sample by size-selective sorting.
基金financially supported by the National Natural Science Foundation of China (Nos. 61571415, 61622406, 51502283)the National Key Research and Development Program of China (Nos. 2017YFA0207500, 2016YFB0700700)the "Hundred Talents Program" of Chinese Academy of Sciences (CAS)
文摘Using diamine as anchoring group, the self-assembled monolayers（SAMs） based on oligo（phenyleneethynylene）s（OPEs） and cruciform OPEs with an extended tetrathiafulvalene（TTF）（OPE3 and OPE3-TTF）were successfully formed on the Au substrate. The Uniformity and stability of SAMs were confirmed through cyclic voltammetry（CV） and electrochemical reductive desorption. The investigation of transport properties of SAMs was achieved by conducting-probe atomic force microscopy（CP-AFM） with both Au and Pt tips. The results indicated that the conductance of OPE3-TTF was 17 and 46 times that of OPE3 for Au and Pt tips, respectively. Theoretical calculations are qualitatively consistent with the experimental results, suggesting that the diamine as anchoring group has a great potential in molecular electronics.
