The rational design of a specific co-drug delivery platform that can address the unavoidable resistance,toxic side effects and low targeting efficiency of traditional cancer treatments is of great meaningful.Herein,Zn...The rational design of a specific co-drug delivery platform that can address the unavoidable resistance,toxic side effects and low targeting efficiency of traditional cancer treatments is of great meaningful.Herein,Zn-based MOF-zeolitic imidazole framework-90(ZIF-90)was selected as the drug delivery carrier,with the cancer therapeutic drug mercaptopurine(6-MP)and glucose oxidase(GOD)as the drug models,hyaluronic acid(HA)was used for protection and targeted delivery,which designed and fabricated an intelligent drug delivery platform(6-MP@ZIF-90@GOD@HA).This platform aims to reduce the toxic side effects of 6-MP and enhance its efficacy while improving the targeting ability of GOD,thereby further enhancing the treatment outcome.Notably,results from both in vitro and in vivo experiments demonstrate that the targeted synergistic chemo/reactive oxygen species(ROS)-mediated/starvation therapy inhibited the cancer cell growth while reducing the chemotherapy toxicity,which provides new possibilities for the development of more precise and effective treatment strategies.展开更多
基金financially supported by the National Natural Science Foundation of China(Nos.22161009 and 82060641)the Thousands of Young and Middle-aged Backbone Teachers Training Project of Guangxi Colleges and Universities(No.Gui-Jiao 2020-58)+2 种基金Guangxi University of Chinese Medicine"Qihuang Project"High-level Talent Team Cultivation Programme(No.202408)Gui Style Xinglin Top Talent Funding Project of Guangxi University of Chinese Medicine(Nos.2022C014 and 2022C005)the Innovation Project of Guangxi Graduate Education(No.YCSW2022342)。
文摘The rational design of a specific co-drug delivery platform that can address the unavoidable resistance,toxic side effects and low targeting efficiency of traditional cancer treatments is of great meaningful.Herein,Zn-based MOF-zeolitic imidazole framework-90(ZIF-90)was selected as the drug delivery carrier,with the cancer therapeutic drug mercaptopurine(6-MP)and glucose oxidase(GOD)as the drug models,hyaluronic acid(HA)was used for protection and targeted delivery,which designed and fabricated an intelligent drug delivery platform(6-MP@ZIF-90@GOD@HA).This platform aims to reduce the toxic side effects of 6-MP and enhance its efficacy while improving the targeting ability of GOD,thereby further enhancing the treatment outcome.Notably,results from both in vitro and in vivo experiments demonstrate that the targeted synergistic chemo/reactive oxygen species(ROS)-mediated/starvation therapy inhibited the cancer cell growth while reducing the chemotherapy toxicity,which provides new possibilities for the development of more precise and effective treatment strategies.
