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人参皂苷Rg1对阿霉素引起的血管内皮细胞损伤的作用及机制研究 被引量:1
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作者 马铂涵 韩兵 +3 位作者 刘婷 王一 黄建华 陶贵周 《中国现代医学杂志》 CAS 2020年第18期1-7,共7页
目的探讨人参皂苷Rg1对阿霉素损伤后血管内皮细胞的作用及其机制。方法该研究分为正常组、阿霉素组(0.5μg/ml)、阿霉素+Rg1组(0.5μg/ml阿霉素+200μg/ml Rg1)。通过MTT法、划痕及小管形成实验检测人参皂苷Rg1对阿霉素损伤后血管内皮... 目的探讨人参皂苷Rg1对阿霉素损伤后血管内皮细胞的作用及其机制。方法该研究分为正常组、阿霉素组(0.5μg/ml)、阿霉素+Rg1组(0.5μg/ml阿霉素+200μg/ml Rg1)。通过MTT法、划痕及小管形成实验检测人参皂苷Rg1对阿霉素损伤后血管内皮细胞增殖、迁移及小管形成的影响。通过Hochst33342染色和流式细胞术检测人参皂苷Rg1对阿霉素损伤后血管内皮细胞凋亡的影响。采用Western blotting检测人参皂苷Rg1对阿霉素损伤后血管内皮细胞Bcl-2、p-Akt、p-ERK及p-eNOS蛋白表达的影响。结果与正常组比较,阿霉素组细胞活性降低(P<0.05);与阿霉素组比较,阿霉素+Rg1组能提高血管内皮细胞的细胞活性(P<0.05)。与阿霉素组比较,阿霉素+Rg1组能够改善血管内皮细胞的迁移及小管形成状态(P<0.05)。与阿霉素组比较,阿霉素+Rg1组减少阿霉素引起的细胞凋亡(P<0.05)。与阿霉素组比较,阿霉素+Rg1组阿霉素损伤后血管内皮细胞NO升高(P<0.05),ROS减少(P<0.05)。阿霉素组Bcl-2、p-ERK、p-Akt及p-eNOS蛋白相对表达量较正常组低(P<0.05),阿霉素+Rg1组较阿霉素组高(P<0.05)。结论人参皂苷Rg1可减轻阿霉素引起的血管内皮细胞损伤,从而为人参皂苷Rg1治疗阿霉素引起的心脏损伤提供新的靶点。 展开更多
关键词 内皮 血管 细胞 心脏损伤
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Ballistic impact response of resistance-spot-welded(RSW) double-layered plates for Q&P980 steel
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作者 bo-han ma Dong-fang ma +2 位作者 Huan-ran Wang Da-nian Chen Feng-hua Zhou 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2022年第6期1052-1064,共13页
Ballistic impact response of resistance-spot-welded(RSW)double-layered(2×1.6 mm)plates(190 mm×150 mm)for Q&P980 steel impacted by a round-nosed steel bullet(12 mm diameter and 30 mm length)was investigat... Ballistic impact response of resistance-spot-welded(RSW)double-layered(2×1.6 mm)plates(190 mm×150 mm)for Q&P980 steel impacted by a round-nosed steel bullet(12 mm diameter and 30 mm length)was investigated by using gas gun and high-speed camera system.The RSW specimens were spot welded using a 6 mm diameter electrode face producing a 7.2 mm diameter fusion zone of the spot weld.The ballistic curve and energy balance for the tests of the spot weld of the RSW specimens at different velocity were analyzed to characterize the ballistic behavior of the RSW specimens under bullet impact.The fracture mechanisms of the RSW specimens under bullet impact were presented.For the tests below the ballistic limit,the cracks initiated from the notch-tip and propagated along the faying surface or obliquely through the thickness depending on the impact velocity.For the tests above the ballistic limit,the plug fracture in the front plate of the RSW specimen could be caused by the thinning-induced necking in the BM near the HAZ,while the plug fracture in the rear plate of the RSW specimens may be consist of the circumferential cracking from the rear surface and the bending fracture of the hinged part of material.The effects of the electrode indentation and the weld interfaces on deformation and fracture of the RSW specimens under bullet impact were revealed.For the tests above the ballistic limit,the circumferential fracture from the rear surface of the RSW specimens was always initiated along the interior periphery of the electrode indentation and the crack paths were along the FZ/CGHAZ or CGHAZ/FGHAZ interface.When the circumferential crack also formed outside the electrode indentation,the fracture on the BM/HAZ interface could be found.On the front plate of the RSW specimens,the shear/bending induced cracking from the notch-tip were observed and the crack paths were along the FZ/CGHAZ or CGHAZ/FGHAZ interface. 展开更多
关键词 RSW Q&P980 steel Ballistic impact Deformation Fracture
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