Chloroquine(CQ)is a weak base that was originally used to treat malaria infection.1 However,recent findings have pinpointed the modulatory effect of CQ in models of chronic inflammation and viral infections.The antivi...Chloroquine(CQ)is a weak base that was originally used to treat malaria infection.1 However,recent findings have pinpointed the modulatory effect of CQ in models of chronic inflammation and viral infections.The antiviral effect of CQ and its derivative hydroxychloroquine has attracted great attention due to the recent Sars-CoV-2 virus outbreak.展开更多
Multiple sclerosis(MS)and its animal model,experimental autoimmune encephalomyelitis(EAE),are chronic neuroinflammatory and demyelinating diseases of the central nervous system(CNS).1 Here,we provide compelling eviden...Multiple sclerosis(MS)and its animal model,experimental autoimmune encephalomyelitis(EAE),are chronic neuroinflammatory and demyelinating diseases of the central nervous system(CNS).1 Here,we provide compelling evidence of the novel anti-inflammatory and neuroprotective therapeutic effects of P7C3 in a CNS autoimmune disease.P7C3 treatment effectively reduces disease severity and improves clinical recovery before,at the onset,and at the peak stage of EAE.These effects,together with direct protection of oligodendrocyte survival,can work synergistically to achieve desirable therapeutic effects in EAE,in which the CNS pathology involves both inflammation and demyelination.The anti-inflammatory and neuroprotective capacity of P7C3 gives it a great therapeutic advantage among current therapies for MS,which is in urgent need of a more effective disease-modifying treatment.展开更多
文摘Chloroquine(CQ)is a weak base that was originally used to treat malaria infection.1 However,recent findings have pinpointed the modulatory effect of CQ in models of chronic inflammation and viral infections.The antiviral effect of CQ and its derivative hydroxychloroquine has attracted great attention due to the recent Sars-CoV-2 virus outbreak.
基金supported by the NIH(Grants All35601 and NS099594)USA.X.L.and Y.Z.were partially supported by the Chinese National Natural Science Foundation(Grant nos.31970771 and 81771345).
文摘Multiple sclerosis(MS)and its animal model,experimental autoimmune encephalomyelitis(EAE),are chronic neuroinflammatory and demyelinating diseases of the central nervous system(CNS).1 Here,we provide compelling evidence of the novel anti-inflammatory and neuroprotective therapeutic effects of P7C3 in a CNS autoimmune disease.P7C3 treatment effectively reduces disease severity and improves clinical recovery before,at the onset,and at the peak stage of EAE.These effects,together with direct protection of oligodendrocyte survival,can work synergistically to achieve desirable therapeutic effects in EAE,in which the CNS pathology involves both inflammation and demyelination.The anti-inflammatory and neuroprotective capacity of P7C3 gives it a great therapeutic advantage among current therapies for MS,which is in urgent need of a more effective disease-modifying treatment.
