Application of support vector machine algorithm for early differential diagnosis of prostate cancer

Prostate cancer(PCa)symptoms are commonly confused with benign prostate hyperplasia(BPH),particularly in the early stages due to similarities between symptoms,and in some instances,underdiagnoses.Clinical methods have been utilized to diagnose PCa;however,at the full-blown stage,clinical methods usually present high risks of complicated side effects.Therefore,we proposed the use of support vector machine for early differential diagnosis of PCa(SVM-PCa-EDD).SVM was used to classify persons with and without PCa.We used the PCa dataset from the Kaggle Healthcare repository to develop and validate SVM model for classification.The PCa dataset consisted of 250 features and one class of features.Attributes considered in this study were age,body mass index(BMI),race,family history,obesity,trouble urinating,urine stream force,blood in semen,bone pain,and erectile dysfunction.The SVM-PCa-EDD was used for preprocessing the PCa dataset,specifically dealing with class imbalance,and for dimensionality reduction.After eliminating class imbalance,the area under the receiver operating characteristic(ROC)curve(AUC)of the logistic regression(LR)model trained with the downsampled dataset was 58.4%,whereas that of the AUC-ROC of LR trained with the class imbalance dataset was 54.3%.The SVM-PCa-EDD achieved 90%accuracy,80%sensitivity,and 80%specificity.The validation of SVM-PCa-EDD using random forest and LR showed that SVM-PCa-EDD performed better in early differential diagnosis of PCa.The proposed model can assist medical experts in early diagnosis of PCa,particularly in resource-constrained healthcare settings and making further recommendations for PCa testing and treatment.

Application of intelligence-based computational techniques for classification and early differential diagnosis of COVID-19 disease

Clinical methods are used for diagnosing COVID-19 infected patients,but reports posit that,several people who were initially tested positive of COVID-19,and who had some underlying diseases,turned out having negative results after further tests.Therefore,the performance of clinical methods is not always guaranteed.Moreover,chest X-ray image data of COVID-19 infected patients are mostly used in the computational models for COVID-19 diagnosis,while the use of common symptoms,such as fever,cough,fatigue,muscle aches,headache,etc.in computational models is not yet reported.In this study,we employed seven classification algorithms to empirically test and verify their efficacy when applied to diagnose COVID-19 using the aforementioned symptoms.We experimented with Logistic Regression(LR),Support Vector Machine(SVM),Naïve Byes(NB),Decision Tree(DT),Multilayer Perceptron(MLP),Fuzzy Cognitive Map(FCM)and Deep Neural Network(DNN)algorithms.The techniques were subjected to random undersampling and oversampling.Our results showed that with class imbalance,MLP and DNN outperform others.However,without class imbalance,MLP,FCM and DNN outperform others with the use of random undersampling,but DNN has the best performance by utilizing random oversampling.This study identified MLP,FCM and DNN as better classifiers over LR,NB,DT and SVM,so that healthcare software system developers can adopt them to develop intelligence-based expert systems which both medical personnel and patients can use for differential diagnosis of COVID-19 based on the aforementioned symptoms.However,the test of performance must not be limited to the traditional performance metrics.