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心肌梗死后骨髓干细胞动员与左室功能 被引量:9
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作者 Leone A. M. Rutella S. +1 位作者 bonanno g. 刘少伟 《世界核心医学期刊文摘(心脏病学分册)》 2005年第12期44-44,共1页
Aims: Recent data suggest that the administration of bone marrow-derived stem cells(BMSC) might improve myocardial perfusion and left ventricular(LV) function after acute myocardial infarction(AMI). The aim of this st... Aims: Recent data suggest that the administration of bone marrow-derived stem cells(BMSC) might improve myocardial perfusion and left ventricular(LV) function after acute myocardial infarction(AMI). The aim of this study was to assess spontaneous mobilization of BMSC expressing the haematopoietic and endothelial progenitor cell-associated antigen CD34+after AMI and its relation to post-infarction remodelling. Methods and results: Peripheral blood concentration of CD34+BMSC was measured by flow cytometry in 54 patients with AMI, 26 patients with chronic stable angina(CSA), and 43 normal healthy subjects. In patients with AMI, LV function was measured by 2D-echocardio-graphy. Eighteen AMI patients were reassessed at 1 year. BMSC concentration was higher in patients with AMI(mean peak value: 7.04±6.27 cells/μL), than in patients with CSA(3.80±2.12 cells/μL, P=0.036) and in healthy controls(1.87±1.52 cells/μL, P< 0.001). At multivariable analysis statin use(P< 0.001), primary percutaneous intervention(P=0.048) and anterior AMI(P=0.05) were the only independent predictors of increased BMSC mobilization after AMI. In the 28 patients without subsequent acute coronary events reassessed at 1 year follow-up,CD34+cell concentration was an independent predictor of global and regional improvement of LV function(r=0.52, P=0.004 and r=-0.41, P=0.03, respectively). Conclusion: AMI is followed by enhanced spontaneous mobilization of BMSC, in particular, in patients on statin therapy and following a primary percutaneous intervention. More importantly persistent spontaneous mobilization of BMSC might contribute to determine a more favourable post-AMI remodelling. 展开更多
关键词 左室功能 骨髓干细胞动员 二维超声心动图 心肌灌注 心肌重构 健康受试者 他汀类药物 流式细胞仪检测 介入治疗 平均峰值
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