Prediction rule for estimating advanced colorectal neoplasm risk in average-risk populations in southern Jiangsu Province

Objective：The aim of this study was to establish the risk scoring system towards the advanced colorectal neoplasm （CN） risk in the average-risk populations in the southern Jiangsu Province,and to evaluate the screening efficacy.Methods：Totally 905 cases of the average-risk populations who received the colonoscopy were selected as the objective.The multivariate logistic regression analysis method was used to establish the scoring system towards the occurrence risk of the advanced tumor,and its screening efficacy was evaluated through the prediction consistency,distinguishing ability and screening accuracy.Results：The scoring system consisted of five variables,namely age,gender,coronary heart disease,egg intake and stool frequency.The results revealed that it had good prediction consistency （P=0.205） and distinguishing ability [the area under the receiver operating characteristic （ROC） curve was 0.75,with 95％ confidence interval （95％ CI） of 0.69-0.82].Thus,2.5 points was set as the screening cutoff value,and its sensitivity,specificity,accuracy,positive predictive value,negative predictive value,positive likelihood ratio and negative likelihood ratio were 93.8 ％,47.6％,50.1％,9.1％,99.3％,1.79 and 0.13,respectively.Conclusions：The established scoring system had good screening efficacy,and can be used as the screening tool applying to the CN screening within the average-risk populations in the southern Jiangsu Province.

The vacA i1 genotype of Helicobacter pylori is associated with peptic ulcer and gastric cancer:A meta-analysis

There are two genotypes of the vacA intermediate region, il and i2; however, the association between the genotypes and gastroduodenal disease remains to be elucidated. The aim of this article was to investigate the interaction between the genotypes and H. py/ori-associated diseases such as chronic gastritis, peptic ulcer disease （PUD） and gastric cancer. Methods： The meta-analysis was performed in Review Manager 4.2.2. Results： Eleven （ten articles and one abstract） met the inclusion criteria and were included. The il genotype increased the risk of PUD （OR = 1.70, 95% CI： 1.24-2.33, P 〈 0.001） and gastric cancer （OR = 3.90, 95% CI： 2.64-5.78, P 〈 0.001）. Sub-analysis showed that the il genotype was significantly associated with gastric ulcers （OR = 2.59, 95% CI： 1.05-6.35, P = 0.040）, but not with duodenal ulcers （OR = 1.04, 95% CI： 0.61-1.76, P = 0.90）. In addition, the association between the il genotype and PUD and GC existed in studies not only from Europe but also Asia, except for the association between the il genotype and PUD in Asian population. Conclusion： The vacA il genotype is associated with an increased risk of the development of peptic ulcer disease （mainly gastric ulcer） and gastric cancer. In geographical distribution, the association between the il genotype and PUD and GC existed in studies not only from Europe but also Asia, except for the association between the il genotype and PUD in Asian population.