Given the interdependence of multiple factors in age-related vestibular loss (e.g., balance, vision,cognition), it is important to examine the individual contributions of these factors with ARVL. While therelationship...Given the interdependence of multiple factors in age-related vestibular loss (e.g., balance, vision,cognition), it is important to examine the individual contributions of these factors with ARVL. While therelationship between the vestibular and visual systems has been well studied (Bronstein et al., 2015),little is known about the association of the peripheral vestibular system with neurodegenerative disorders (Cronin et al., 2017). Further, emerging research developments implicate the vestibular system asan opportunity for examining brain function beyond balance, and into other areas, such as cognition andpsychological functioning. Additionally, the bidirectional impact of psychological functioning is understudied in ARVL. Recognition of ARVL as part of a multifaceted aging process will help guide thedevelopment of integrated interventions for patients who remain at risk for decline. In this review, wewill discuss a wide variety of characteristics of the peripheral vestibular system and ARVL, how it relatesto neurodegenerative diseases, and correlations between ARVL and balance, vision, cognitive, and psychological dysfunction. We also discuss clinical implications as well as future directions for research, withan emphasis on improving care for patients with ARVL.展开更多
Focal intraretinal alterations have been studied to advance our understanding of the pathology of neurodegenerative diseases.The current literature involving focal alterations in the intraretinal layers was reviewed t...Focal intraretinal alterations have been studied to advance our understanding of the pathology of neurodegenerative diseases.The current literature involving focal alterations in the intraretinal layers was reviewed through PubMed using the search terms“focal alteration”,“region of interest”,“optical coherence tomography”,“glaucoma”,“multiple sclerosis”,“Alzheimer’s disease”,“Parkinson disease”,“neurodegenerative diseases”and other related items.It was found that focal alterations of intraretinal layers were different in various neurodegenerative diseases.The typical focal thinning might help differentiate various ocular and cerebral diseases,track disease progression,and evaluate the outcome of clinical trials.Advanced exploration of focal intraretinal alterations will help to further validate their clinical and research utility.展开更多
文摘Given the interdependence of multiple factors in age-related vestibular loss (e.g., balance, vision,cognition), it is important to examine the individual contributions of these factors with ARVL. While therelationship between the vestibular and visual systems has been well studied (Bronstein et al., 2015),little is known about the association of the peripheral vestibular system with neurodegenerative disorders (Cronin et al., 2017). Further, emerging research developments implicate the vestibular system asan opportunity for examining brain function beyond balance, and into other areas, such as cognition andpsychological functioning. Additionally, the bidirectional impact of psychological functioning is understudied in ARVL. Recognition of ARVL as part of a multifaceted aging process will help guide thedevelopment of integrated interventions for patients who remain at risk for decline. In this review, wewill discuss a wide variety of characteristics of the peripheral vestibular system and ARVL, how it relatesto neurodegenerative diseases, and correlations between ARVL and balance, vision, cognitive, and psychological dysfunction. We also discuss clinical implications as well as future directions for research, withan emphasis on improving care for patients with ARVL.
基金The work was supported by the National Multiple Sclerosis Society(RG-1506-04890)NIH Center Grant P30 EY014801,NINDS 1R01NS111115-01(Wang)a grant from Research to Prevent Blindness(RPB).
文摘Focal intraretinal alterations have been studied to advance our understanding of the pathology of neurodegenerative diseases.The current literature involving focal alterations in the intraretinal layers was reviewed through PubMed using the search terms“focal alteration”,“region of interest”,“optical coherence tomography”,“glaucoma”,“multiple sclerosis”,“Alzheimer’s disease”,“Parkinson disease”,“neurodegenerative diseases”and other related items.It was found that focal alterations of intraretinal layers were different in various neurodegenerative diseases.The typical focal thinning might help differentiate various ocular and cerebral diseases,track disease progression,and evaluate the outcome of clinical trials.Advanced exploration of focal intraretinal alterations will help to further validate their clinical and research utility.
