With the continuous in-depth study of the interaction mechanism between viruses and hosts,the virus has become a promising tool in cancer treatment.In fact,many oncolytic viruses with selectivity and effectiveness hav...With the continuous in-depth study of the interaction mechanism between viruses and hosts,the virus has become a promising tool in cancer treatment.In fact,many oncolytic viruses with selectivity and effectiveness have been used in cancer therapy.Human enterovirus is one of the most convenient sources to generate oncolytic viruses,however,the high seroprevalence of some enteroviruses limits its application which urges to exploit more oncolytic enteroviruses.展开更多
The outbreak of COVID-19 has posed a huge threat to global health and economy.Countermeasures have revolutionized norms for working,socializing,learning,and travel.Importantly,vaccines have been considered as most eff...The outbreak of COVID-19 has posed a huge threat to global health and economy.Countermeasures have revolutionized norms for working,socializing,learning,and travel.Importantly,vaccines have been considered as most effective tools to combat with COVID-19.As of the beginning of 2021,>200 COVID-19 vaccine candidates,covering nearly all existing technologies and platforms,are being research and development(R&D)by multiple manufacturers worldwide.This has posed a huge obstacle to the quality control and evaluation of those candidate vaccines,especially in China,where five vaccine platforms are deployed in parallel.To accelerate the R&D progress of COVID-19 vaccines,the guidances on R&D of COVID-19 vaccine have been issued by National Regulatory Authorities or organizations worldwide.The Center for Drug Evaluation and national quality control laboratory in China have played a leading role in launching the research on quality control and evaluation in collaboration with relevant laboratories involved in the vaccine R&D,which greatly supported the progression of vaccines R&D,and accelerated the approval for emergency use and conditional marketing of currently vaccine candidates.In this paper,the progress and experience gained in quality control and evaluation of COVID-19 vaccines developed in China are summarized,which might provide references for the R&D of current and next generation of COVID-19 vaccines worldwide.展开更多
Dear Editor,Enteroviruses belonging to the family Picornaviridae are nonenveloped RNA viruses that cause hand-foot-mouth disease(HFMD),which can lead to severe neurological complications.Enteroviruses genomes represen...Dear Editor,Enteroviruses belonging to the family Picornaviridae are nonenveloped RNA viruses that cause hand-foot-mouth disease(HFMD),which can lead to severe neurological complications.Enteroviruses genomes represent a single open reading frame flanked by 5’-and 3’-untranslated terminal regions(UTRs).展开更多
文摘With the continuous in-depth study of the interaction mechanism between viruses and hosts,the virus has become a promising tool in cancer treatment.In fact,many oncolytic viruses with selectivity and effectiveness have been used in cancer therapy.Human enterovirus is one of the most convenient sources to generate oncolytic viruses,however,the high seroprevalence of some enteroviruses limits its application which urges to exploit more oncolytic enteroviruses.
基金the Major Special Projects Funding Program of the Ministry of Science and Technology of the People's Republic of China under Grant No.2020YFC0860500.
文摘The outbreak of COVID-19 has posed a huge threat to global health and economy.Countermeasures have revolutionized norms for working,socializing,learning,and travel.Importantly,vaccines have been considered as most effective tools to combat with COVID-19.As of the beginning of 2021,>200 COVID-19 vaccine candidates,covering nearly all existing technologies and platforms,are being research and development(R&D)by multiple manufacturers worldwide.This has posed a huge obstacle to the quality control and evaluation of those candidate vaccines,especially in China,where five vaccine platforms are deployed in parallel.To accelerate the R&D progress of COVID-19 vaccines,the guidances on R&D of COVID-19 vaccine have been issued by National Regulatory Authorities or organizations worldwide.The Center for Drug Evaluation and national quality control laboratory in China have played a leading role in launching the research on quality control and evaluation in collaboration with relevant laboratories involved in the vaccine R&D,which greatly supported the progression of vaccines R&D,and accelerated the approval for emergency use and conditional marketing of currently vaccine candidates.In this paper,the progress and experience gained in quality control and evaluation of COVID-19 vaccines developed in China are summarized,which might provide references for the R&D of current and next generation of COVID-19 vaccines worldwide.
基金supported by the National Key Research and Development Project(grant number 2018ZX09737-011)。
文摘Dear Editor,Enteroviruses belonging to the family Picornaviridae are nonenveloped RNA viruses that cause hand-foot-mouth disease(HFMD),which can lead to severe neurological complications.Enteroviruses genomes represent a single open reading frame flanked by 5’-and 3’-untranslated terminal regions(UTRs).
