Zika virus is a new global threat for 2016 that has been swept to almost all Americas and is now posing serious threats to the entire globe.This deadly virus is playing havoc to unborn lives because of its reported as...Zika virus is a new global threat for 2016 that has been swept to almost all Americas and is now posing serious threats to the entire globe.This deadly virus is playing havoc to unborn lives because of its reported association with upsurge of fetal deformation called microcephaly and neuropathic disorders including Guillain-Barrésyndrome.Till today,there is no vaccine prospect,antiviral therapy or licensed medical countermeasures to curb the teratogenic outcomes of this destructive viral infection.Diagnosis,treatment,chronicity and pathogenesis are still vague and unsettled.Therefore,this review article addresses all the aspects related to this disease to mitigate the explosive rise in Zika virus infection.展开更多
Objective: To determine the breadth of Zika virus(ZIKV)-associated brain anomalies in neonates and adults. Methods: Systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Met...Objective: To determine the breadth of Zika virus(ZIKV)-associated brain anomalies in neonates and adults. Methods: Systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA) statement using electronic databases ScienceDirect, Pubmed, Medline, Scopus, and Global Health Library.Only those research articles, case studies, case-control studies, case-cohort studies, crosssectional studies, and organizational survey reports were included in the study that reported any fetal outcomes for pregnant women who had infected with ZIKV during the gestational period and ZIKV-related neurological complications in adults as well. Results: Out of total 72 retrieved articles, 50 met the inclusion criteria. We estimated a significant increase in incidence of neural abnormalities such as Guillain-Barre syndrome and microcephaly in the regions that are experiencing ZIKV outbreaks. Other neurological malformations found in ZIKV patients include hydrancephaly/hydrops fetalis, myasthenia gravis,meningoencephalitis and myelitis. Conclusion: Our systematic analysis provides the broad spectrum of neurological malformations in ZIKV infected patients and these data further support the causal link of ZIKV with neurological disorders.展开更多
Zika virus(ZIKV) is rapidly spreading across the America and its devastating outcomes for pregnant women and infants have driven this previously ignored pathogen into the limelight.Clinical manifestations are fever,jo...Zika virus(ZIKV) is rapidly spreading across the America and its devastating outcomes for pregnant women and infants have driven this previously ignored pathogen into the limelight.Clinical manifestations are fever,joint pain or rash and conjunctivitis.Emergence of ZIKV started with a first outbrcak in the Pacific arca in 2007.a second large outbreak occurred in the Pacific in 2013/2014 and subsequently the virus spread in other Pacific islands.Threat of explosive global pandemic and severe clinical complications linked with the more immediate and recurrent epidemics necessitate the development of an effective vaccine.Several vaccine platforms such as DNA vaccine,recombinant subunit vaccine.ZIKV purified inactivated vaccine,and chimeric vaccines have shown potent efficacy in ritro and in rim trials.Moreover,number of drugs such as Sofosbuvir.BCX4450.NITD008 and 7-DMA are ready to enter phase I clinical trial because of proven anti-ZIKV activity.Monoclonal based antibodies offer promise as an intervention effective for use in pregnant women.In this review,we describe the advances in research on ZIKV such as research strategies for the development of antiviral drugs & vaccines,molecular evolution,epidemiology emergence,neurological complications and other teratogenic outcomes as well as pathogenesis.展开更多
Dear editor,Zika virus(ZIKV)crisis,which caught Brazil in 2015,heralded the rapid spread throughout Americas and has imparted catastrophic devastation to human population in the form of severe
文摘Zika virus is a new global threat for 2016 that has been swept to almost all Americas and is now posing serious threats to the entire globe.This deadly virus is playing havoc to unborn lives because of its reported association with upsurge of fetal deformation called microcephaly and neuropathic disorders including Guillain-Barrésyndrome.Till today,there is no vaccine prospect,antiviral therapy or licensed medical countermeasures to curb the teratogenic outcomes of this destructive viral infection.Diagnosis,treatment,chronicity and pathogenesis are still vague and unsettled.Therefore,this review article addresses all the aspects related to this disease to mitigate the explosive rise in Zika virus infection.
文摘Objective: To determine the breadth of Zika virus(ZIKV)-associated brain anomalies in neonates and adults. Methods: Systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA) statement using electronic databases ScienceDirect, Pubmed, Medline, Scopus, and Global Health Library.Only those research articles, case studies, case-control studies, case-cohort studies, crosssectional studies, and organizational survey reports were included in the study that reported any fetal outcomes for pregnant women who had infected with ZIKV during the gestational period and ZIKV-related neurological complications in adults as well. Results: Out of total 72 retrieved articles, 50 met the inclusion criteria. We estimated a significant increase in incidence of neural abnormalities such as Guillain-Barre syndrome and microcephaly in the regions that are experiencing ZIKV outbreaks. Other neurological malformations found in ZIKV patients include hydrancephaly/hydrops fetalis, myasthenia gravis,meningoencephalitis and myelitis. Conclusion: Our systematic analysis provides the broad spectrum of neurological malformations in ZIKV infected patients and these data further support the causal link of ZIKV with neurological disorders.
文摘Zika virus(ZIKV) is rapidly spreading across the America and its devastating outcomes for pregnant women and infants have driven this previously ignored pathogen into the limelight.Clinical manifestations are fever,joint pain or rash and conjunctivitis.Emergence of ZIKV started with a first outbrcak in the Pacific arca in 2007.a second large outbreak occurred in the Pacific in 2013/2014 and subsequently the virus spread in other Pacific islands.Threat of explosive global pandemic and severe clinical complications linked with the more immediate and recurrent epidemics necessitate the development of an effective vaccine.Several vaccine platforms such as DNA vaccine,recombinant subunit vaccine.ZIKV purified inactivated vaccine,and chimeric vaccines have shown potent efficacy in ritro and in rim trials.Moreover,number of drugs such as Sofosbuvir.BCX4450.NITD008 and 7-DMA are ready to enter phase I clinical trial because of proven anti-ZIKV activity.Monoclonal based antibodies offer promise as an intervention effective for use in pregnant women.In this review,we describe the advances in research on ZIKV such as research strategies for the development of antiviral drugs & vaccines,molecular evolution,epidemiology emergence,neurological complications and other teratogenic outcomes as well as pathogenesis.
文摘Dear editor,Zika virus(ZIKV)crisis,which caught Brazil in 2015,heralded the rapid spread throughout Americas and has imparted catastrophic devastation to human population in the form of severe
