独自静坐在flower·time的角落里,凝望窗外,夜空没有星星.
MD传来的是的westlife的<Angel>"In the arms of the angel .fly away from here.from this dark cold hotel room.and the endlessness that you fear.you are ...独自静坐在flower·time的角落里,凝望窗外,夜空没有星星.
MD传来的是的westlife的<Angel>"In the arms of the angel .fly away from here.from this dark cold hotel room.and the endlessness that you fear.you are pulled from the wreckage.of your silent reverie.you're in the arms of the angel.may you find some comfort there……"展开更多
Viruses are obligate intracellular parasites that subvert cellular metabolism and pathways to mediate their own replication—normally at the expense of the host cell. Polyomaviruses are a group of small DNA viruses, w...Viruses are obligate intracellular parasites that subvert cellular metabolism and pathways to mediate their own replication—normally at the expense of the host cell. Polyomaviruses are a group of small DNA viruses, which have long been studied as a model for eukaryotic DNA replication. Polyomaviruses manipulate host replication proteins, as well as proteins involved in DNA maintenance and repair, to serve as essential cofactors for productive infection. Moreover, evidence suggests that polyomavirus infection poses a unique genotoxic threat to the host cell. In response to any source of DNA damage, cells must initiate an effective DNA damage response(DDR) to maintain genomic integrity, wherein two protein kinases, ataxia telangiectasia mutated(ATM) and ATM- and Rad3-related(ATR), are major regulators of DNA damage recognition and repair. Recent investigation suggests that these essential DDR proteins are required for productive polyomavirus infection. This review will focus on polyomaviruses and their interaction with ATMand ATR-mediated DNA damage responses and the effect of this interaction on host genomic stability.展开更多
文摘独自静坐在flower·time的角落里,凝望窗外,夜空没有星星.
MD传来的是的westlife的<Angel>"In the arms of the angel .fly away from here.from this dark cold hotel room.and the endlessness that you fear.you are pulled from the wreckage.of your silent reverie.you're in the arms of the angel.may you find some comfort there……"
基金supported by the UAB Department of Microbiology start-up funda UAB faculty development grant+1 种基金a UAB Cancer Center Pilot Program Project granta YSB UAB Cancer Center New Faculty Development Award to M Jiang
文摘Viruses are obligate intracellular parasites that subvert cellular metabolism and pathways to mediate their own replication—normally at the expense of the host cell. Polyomaviruses are a group of small DNA viruses, which have long been studied as a model for eukaryotic DNA replication. Polyomaviruses manipulate host replication proteins, as well as proteins involved in DNA maintenance and repair, to serve as essential cofactors for productive infection. Moreover, evidence suggests that polyomavirus infection poses a unique genotoxic threat to the host cell. In response to any source of DNA damage, cells must initiate an effective DNA damage response(DDR) to maintain genomic integrity, wherein two protein kinases, ataxia telangiectasia mutated(ATM) and ATM- and Rad3-related(ATR), are major regulators of DNA damage recognition and repair. Recent investigation suggests that these essential DDR proteins are required for productive polyomavirus infection. This review will focus on polyomaviruses and their interaction with ATMand ATR-mediated DNA damage responses and the effect of this interaction on host genomic stability.
