Our objective was to evaluate the prognostic information of preprocedural serum N-terminus pro-brain natriuretic peptide(NT-pro-BNP) levels to predict the long-term outcome after percutaneous coronary intervention(PCI...Our objective was to evaluate the prognostic information of preprocedural serum N-terminus pro-brain natriuretic peptide(NT-pro-BNP) levels to predict the long-term outcome after percutaneous coronary intervention(PCI). A total of 891 consecutive patients with stable or unstable angina pectoris with normal serum troponin T levels(≤ 0.03 μ g/L) undergoing PCI were investigated. For each patient with a cardiovascular event(death or nonfatal myocardial infarction), 2 event-free patients were used as controls. The procedure was successful in all patients, and follow-up was complete. By the end of the follow-up period(mean 2.6 years), 75 patients had had a cardiovascular event(41 deaths and 34 nonfatal myocardial infarctions). On multivariate analysis, lesion severity, diabetes mellitus, and NT-pro-BNP levels in the highest quartile(>490 mg/L)were identified as independent factors for death or nonfatal myocardial infarction after PCI. In conclusion, preprocedural NT-pro-BNP levels are associated with long-term outcome after PCI. The use of NT-pro-BNP can be of value in risk stratification in patients undergoing PCI.展开更多
文摘Our objective was to evaluate the prognostic information of preprocedural serum N-terminus pro-brain natriuretic peptide(NT-pro-BNP) levels to predict the long-term outcome after percutaneous coronary intervention(PCI). A total of 891 consecutive patients with stable or unstable angina pectoris with normal serum troponin T levels(≤ 0.03 μ g/L) undergoing PCI were investigated. For each patient with a cardiovascular event(death or nonfatal myocardial infarction), 2 event-free patients were used as controls. The procedure was successful in all patients, and follow-up was complete. By the end of the follow-up period(mean 2.6 years), 75 patients had had a cardiovascular event(41 deaths and 34 nonfatal myocardial infarctions). On multivariate analysis, lesion severity, diabetes mellitus, and NT-pro-BNP levels in the highest quartile(>490 mg/L)were identified as independent factors for death or nonfatal myocardial infarction after PCI. In conclusion, preprocedural NT-pro-BNP levels are associated with long-term outcome after PCI. The use of NT-pro-BNP can be of value in risk stratification in patients undergoing PCI.
