Background and Purpose -A relationship between the apolipoprotein E (apoE) genotype and ischemic stroke has been inconsistently reported. We explored this relation in the Atherosclerosis Risk in Communities Study (ARI...Background and Purpose -A relationship between the apolipoprotein E (apoE) genotype and ischemic stroke has been inconsistently reported. We explored this relation in the Atherosclerosis Risk in Communities Study (ARIC). Methods -The ARIC cohort involves 15 792 men and women, aged 45 to 64 years at baseline and sampled from 4 U.S. communities. Between 1987 and 2001, 498 incident ischemic strokes occurred. Results-After stratifying by race and sex and adjusting for other nonlipid risk factors, there was no significant relation between the apoE genotype and incident stroke, except in black women (hazard ratio for ∈2 genotype relative to ∈3/∈3=0.53; 95%CI, 0.28 to 0.99). Conclusions -For the most part, in this middleaged sample, apoE was not a risk factor for incident ischemic stroke.展开更多
文摘Background and Purpose -A relationship between the apolipoprotein E (apoE) genotype and ischemic stroke has been inconsistently reported. We explored this relation in the Atherosclerosis Risk in Communities Study (ARIC). Methods -The ARIC cohort involves 15 792 men and women, aged 45 to 64 years at baseline and sampled from 4 U.S. communities. Between 1987 and 2001, 498 incident ischemic strokes occurred. Results-After stratifying by race and sex and adjusting for other nonlipid risk factors, there was no significant relation between the apoE genotype and incident stroke, except in black women (hazard ratio for ∈2 genotype relative to ∈3/∈3=0.53; 95%CI, 0.28 to 0.99). Conclusions -For the most part, in this middleaged sample, apoE was not a risk factor for incident ischemic stroke.
