期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Feeding of grey squirrels (Sciurus carolinensis) with the contraceptive agent DiazaCon^(TM):effect on cholesterol, hematology, and blood chemistry
1
作者 Christi A.YODER brenda a.mayle +2 位作者 Carol A.FURCOLOW David P.COWAN Kathleen A.FAGERSTONE 《Integrative Zoology》 SCIE CSCD 2011年第4期409-419,共11页
Grey squirrels(Sciurus carolinensis)are an invasive species in Britain and Italy.They have replaced native red squirrels(Sciurus vulgaris)throughout most of Britain,and cause damage to trees.Currently,lethal control i... Grey squirrels(Sciurus carolinensis)are an invasive species in Britain and Italy.They have replaced native red squirrels(Sciurus vulgaris)throughout most of Britain,and cause damage to trees.Currently,lethal control is used to manage grey squirrel populations in Britain,but nonlethal methods might be more acceptable to the public.One such method is contraception with 20,25-diazacholesterol dihydrochloride(DiazaCon^(TM)).DiazaCon^(TM) inhibits the conversion of desmosterol to cholesterol,resulting in increasing desmosterol concentrations and decreasing cholesterol concentrations.Because cholesterol is needed for the synthesis of steroid reproductive hormones,such as progesterone and testosterone,inhibition of cholesterol synthesis indirectly inhibits reproduction.Desmosterol is used as a marker of efficacy in laboratory studies with species that do not reproduce readily in captivity.Grey squirrels were gavaged with a DiazaCon^(TM) solution for 2 days,and then fed DiazaCon^(TM)-coated peanuts for an additional 8 days at target doses of 50 and 100 mg DiazaCon^(TM) per kg body weight.There was a significant difference in cholesterol concentrations in the treatment groups compared to the control group.Cholesterol was reduced by≥40%for 2 months in both treatment groups.There were no differences among groups with respect to blood chemistry and hematology parameters,and mean values are reported.The mean overall dose of DiazaCon^(TM) received was 29.0±1.6 and 55.3±4.3 mg/kg in the low(50 mg/kg)and high dose(100 mg/kg)groups,respectively.DiazaCon^(TM) might provide an effective,acceptable alternative to lethal control. 展开更多
关键词 20 25-diazacholesterol dihydrochloride CHOLESTEROL CONTRACEPTION DiazaCon^(TM) grey squirrel
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部