AB026. Referrals from optometry-a comparative study (the R.O.C.S study)

Background:To characterize emergency optometrist referrals triaged at a tertiary ophthalmology care center by pathology,physical exam findings,and provisional diagnosis accuracy.Methods:Variables extracted from the patients’charts included date of referral,age,sex,eye(s)under examination,visual acuity(VA)at the time of referral,intraocular pressure(IOP)at the time of the referral,the referring optometrist’s provisional diagnosis,VA at the time of the ophthalmologist consultation,IOP at the time of the ophthalmologist consultation,number of days between referral and ophthalmic consultation,and the ophthalmologist’s diagnosis.Results:After categorizing disease by anatomical location,absolute agreement between optometrist provisional diagnosis and ophthalmologist diagnosis was 60%.A strong correlation was found between optometrist and ophthalmologist VA measurements.IOP measurements were checked less frequently by optometrists.In cases where referral IOP was documented,no significant difference was observed between optometrist and ophthalmologist IOP measures.Conclusions:VA and IOP measurements by optometrists are reliable,but IOP is less frequently checked in the optometry setting.While optometrist referrals correctly localized eye pathology in 60%of cases,posterior pathology was missed in two cases of retinal tear and retinal detachment.

Microbial resistance to nanotechnologies:An important but understudied consideration using antimicrobial nanotechnologies in orthopaedic implants

Microbial resistance to current antibiotics therapies is a major cause of implant failure and adverse clinical outcomes in orthopaedic surgery.Recent developments in advanced antimicrobial nanotechnologies provide numerous opportunities to effective remove resistant bacteria and prevent resistance from occurring through unique mechanisms.With tunable physicochemical properties,nanomaterials can be designed to be bactericidal,antifouling,immunomodulating,and capable of delivering antibacterial compounds to the infection region with spatiotemporal accuracy.Despite its substantial advancement,an important,but under-explored area,is potential microbial resistance to nanomaterials and how this can impact the clinical use of antimicrobial nanotechnologies.This review aims to provide a better understanding of nanomaterial-associated microbial resistance to accelerate bench-to-bedside translations of emerging nanotechnologies for effective control of implant associated infections.

Sodium variability is associated with increased mortality in severe burn injury

Background:Dysnatremias are associated with increased mortality in critically ill patients. Hypernatremia in burn patients is also associated with poor survival. Based on these findings, we hypothesized that high plasma sodium variability is a marker for increased mortality in severely burn-injured patients. Methods:We performed a retrospective review of adult burn patients with a burn injury of 15%total body surface area (TBSA) or greater from 2010 to 2014. All patients included in the study had at least three serum sodium levels checked during admission. We used multivariate logistic regression analysis to determine if hypernatremia, hyponatremia, or sodium variability independently increased the odds ratio (OR) for death. Results:Two hundred twelve patients met entry criteria. Mean age and%TBSA for the study was 45 ± 18 years and 32 ± 19%. Twenty-nine patients died for a mortality rate of 14%. Serum sodium was measured 10,310 times overall. The median number of serum sodium measurements per patient was 22. Non-survivors were older (59 ± 19 vs. 42 ± 16 years) and suffered from a more severe burn injury (50 ± 25%vs. 29 ± 16%TBSA). While mean sodium was significantly higher for non-survivors (138 ± 3 milliequivalents/liter (meq/l)) than for survivors (135 ± 2 meq/l), mean sodium levels remained within the laboratory reference range (135 to 145 meq/l) for both groups. Non-survivors had a significantly higher median number of hypernatremic (>145 meq/l) measurements (2 vs. 0). Coefficient of variation (CV) was significantly higher in non-survivors (2.85 ± 1.1) than survivors (2.0 ± 0.7). Adjusting for TBSA, age, ventilator days, and intensive care unit (ICU) stay, a higher CV of sodium measurements was associated with mortality (OR 5.8 (95%confidence interval (CI) 1.5 to 22)). Additionally, large variation in sodium ranges in the first 10 days of admission may be associated with increased mortality (OR 1.35 (95%CI 1.06 to1.7)). Conclusions:Increased variability in plasma sodium may be associated with death in severely burned patients.