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Activated systemic inflammatory response at diagnosis reduces lymph node count in colonic carcinoma 被引量:1
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作者 Rory P Kennelly Brenda Murphy +2 位作者 john O Larkin brian j mehigan Paul H McCormick 《World Journal of Gastrointestinal Oncology》 SCIE CAS 2016年第8期623-628,共6页
AIM: To investigate a link between lymph node yield and systemic inflammatory response in colon cancer. METHODS: A prospectively maintained database was interrogated. All patients undergoing curative colonic resection... AIM: To investigate a link between lymph node yield and systemic inflammatory response in colon cancer. METHODS: A prospectively maintained database was interrogated. All patients undergoing curative colonic resection were included. Neutrophil lymphocyte ratio(NLR) and albumin were used as markers of SIR. In keeping with previously studies, NLR ≥ 4, albumin < 35 was used as cut off points for SIR. Statistical analysis was performed using 2 sample t-test and χ~2 tests where appropriate.RESULTS: Three hundred and two patients were included for analysis. One hundred and ninety-five patients had NLR < 4 and 107 had NLR ≥ 4. There was no difference in age or sex between groups. Patients with NLR of ≥ 4 had lower mean lymph node yields than patients with NLR < 4 [17.6 ± 7.1 vs 19.2 ± 7.9(P = 0.036)]. More patients with an elevated NLR had node positive disease and an increased lymph node ratio(≥ 0.25, P = 0.044). CONCLUSION: Prognosis in colon cancer is intimately linked to the patient’s immune response. Assuming standardised surgical technique and sub specialty pathology, lymph node count is reduced when systemic inflammatory response is activated. 展开更多
关键词 Systemic inflammatory response LYMPH NODE yield LYMPH NODE COUNT Colon cancer Colonic cancer Neutrophil-lymphocyte RATIO NEUTROPHIL to LYMPHOCYTE RATIO LYMPH NODE RATIO
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