To determine the sensitivity and specificity of measurements of the retinal ne rve fiber layer (RNFL) using the StratusOCT in glaucoma subjects with visual fie ld (VF) defects. Prospective cross-sectional study. One h...To determine the sensitivity and specificity of measurements of the retinal ne rve fiber layer (RNFL) using the StratusOCT in glaucoma subjects with visual fie ld (VF) defects. Prospective cross-sectional study. One hundred nine normal and 63 glaucoma subjects. Fast RNFL scans were performed in one eye of each patient using the StratusOCT. Sensitivity and specificity of different optical coherenc e tomography (OCT) criteria for identifying glaucoma subjects with glaucomatous VF defects. Areas under the receiver operating characteristic curves (AROCs) for various OCT parameters. Severity of VF defects in the glaucoma group was distri buted between mild (18 subjects), moderate (21 subjects), and severe (24 subject s). The average mean deviation of the glaucoma fields was-8.4 decibels (dB), wi th a standard deviation of 6.0 dB and a range from-0.14 to -28.0 dB. The sensi tivity and specificity using a criterion of average RNFL thickness abnormal at t he < 5%level were 84%and 98%, respectively. The sensitivity and specificity u sing a criterion of average RNFL thickness abnormal at the < 1%level were 68%a nd 100%. The sensitivity and specificity of using a criterion of ≥1 quadrants abnormal at the < 5%level were 89%and 95%. The sensitivity and specificity of using a criterion of ≥1 quadrants abnormal at the < 1%level were 83%and 100 %. The sensitivity and specificity of using a criterion of ≥1 clock hours abno rmal at the < 5%level were 89%and 92%. The sensitivity and specificity of usi ng a criterion of ≥1 quadrants abnormal at the < 1%level were 83%and 100%. T he AROC for mean RNFL thickness was 0.966. Other high AROC values included the s uperior quadrant (0.952), inferior quadrant (0.971), inferotemporal clock hour a t 7-o’clock (right eye) and 5-o’clock (left eye) (0.959), 6-o’clock hour ( 0.940), superotemporal clock hour at 11-o’clock (right eye) and 1-o’clock (l eft eye) (0.935), and 12-o’clock hour (0.924). The sensitivity and specificity of RNFL measurements using the new StratusOCT for glaucoma with manifest VF def ects are excellent. The best parameters seem to be ≥1 quadrants abnormal at the ≤5%level or ≥1 clock hours abnormal at the ≤5%level. Future studies are ne eded to determine the sensitivity and specificity of this new technology for gla ucoma without VF defects.展开更多
文摘To determine the sensitivity and specificity of measurements of the retinal ne rve fiber layer (RNFL) using the StratusOCT in glaucoma subjects with visual fie ld (VF) defects. Prospective cross-sectional study. One hundred nine normal and 63 glaucoma subjects. Fast RNFL scans were performed in one eye of each patient using the StratusOCT. Sensitivity and specificity of different optical coherenc e tomography (OCT) criteria for identifying glaucoma subjects with glaucomatous VF defects. Areas under the receiver operating characteristic curves (AROCs) for various OCT parameters. Severity of VF defects in the glaucoma group was distri buted between mild (18 subjects), moderate (21 subjects), and severe (24 subject s). The average mean deviation of the glaucoma fields was-8.4 decibels (dB), wi th a standard deviation of 6.0 dB and a range from-0.14 to -28.0 dB. The sensi tivity and specificity using a criterion of average RNFL thickness abnormal at t he < 5%level were 84%and 98%, respectively. The sensitivity and specificity u sing a criterion of average RNFL thickness abnormal at the < 1%level were 68%a nd 100%. The sensitivity and specificity of using a criterion of ≥1 quadrants abnormal at the < 5%level were 89%and 95%. The sensitivity and specificity of using a criterion of ≥1 quadrants abnormal at the < 1%level were 83%and 100 %. The sensitivity and specificity of using a criterion of ≥1 clock hours abno rmal at the < 5%level were 89%and 92%. The sensitivity and specificity of usi ng a criterion of ≥1 quadrants abnormal at the < 1%level were 83%and 100%. T he AROC for mean RNFL thickness was 0.966. Other high AROC values included the s uperior quadrant (0.952), inferior quadrant (0.971), inferotemporal clock hour a t 7-o’clock (right eye) and 5-o’clock (left eye) (0.959), 6-o’clock hour ( 0.940), superotemporal clock hour at 11-o’clock (right eye) and 1-o’clock (l eft eye) (0.935), and 12-o’clock hour (0.924). The sensitivity and specificity of RNFL measurements using the new StratusOCT for glaucoma with manifest VF def ects are excellent. The best parameters seem to be ≥1 quadrants abnormal at the ≤5%level or ≥1 clock hours abnormal at the ≤5%level. Future studies are ne eded to determine the sensitivity and specificity of this new technology for gla ucoma without VF defects.
