Cytoplasmic body myopathy (CBM) is characterized by proteinaceous inclusion bo dies in muscle tissue. A 43 year old woman presented with rapidly progressive weakness and dysphagia. Electromyography (EMG) elsewhere dem...Cytoplasmic body myopathy (CBM) is characterized by proteinaceous inclusion bo dies in muscle tissue. A 43 year old woman presented with rapidly progressive weakness and dysphagia. Electromyography (EMG) elsewhere demonstrated lower lim b chronic partial denervation. Muscle biopsy showed fiber size variation without diagnostic features. A diagnosis of possible motor neuron disease was made and the patient was commenced on riluzole. Subsequently, the patients condition st abilized, prompting reassessment. Repeat EMG demonstrated no features of denervation and was more suggestive of a myopathic process. Review of the orig inal muscle biopsy showed cytoplasmic bodies. The case highlights a further diag nostic possibility in the assessment of patients with “possible”motor neuron d isease. The clinical features of CBM are briefly reviewed.展开更多
文摘Cytoplasmic body myopathy (CBM) is characterized by proteinaceous inclusion bo dies in muscle tissue. A 43 year old woman presented with rapidly progressive weakness and dysphagia. Electromyography (EMG) elsewhere demonstrated lower lim b chronic partial denervation. Muscle biopsy showed fiber size variation without diagnostic features. A diagnosis of possible motor neuron disease was made and the patient was commenced on riluzole. Subsequently, the patients condition st abilized, prompting reassessment. Repeat EMG demonstrated no features of denervation and was more suggestive of a myopathic process. Review of the orig inal muscle biopsy showed cytoplasmic bodies. The case highlights a further diag nostic possibility in the assessment of patients with “possible”motor neuron d isease. The clinical features of CBM are briefly reviewed.
