Four polyphenols were isolated and purified from a brown alga </span><i><span style="font-family:Verdana;">Eisenia arborea</span></i><span style="font-family:Verdana;&qu...Four polyphenols were isolated and purified from a brown alga </span><i><span style="font-family:Verdana;">Eisenia arborea</span></i><span style="font-family:Verdana;">. These phlorotannin compounds showed strong radical scavenging and some enzyme inhibitory activities. All of the compounds showed strong antioxidative, acetylcholinesterase and butyrylcholinesterase inhibitory, and tyrosinase inhbibitory activities at 100 μg/mL. Dieckol and PFF inhibited butyrylcholinesterase, a new target for the treatment of Alzheimer’s disease, very strongly even at 10 μg/mL</span></span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> more strongly than AChE. These two compounds also effectively inhibited tyrosinase. These results support the potential of developing natural antioxidants and antidementia agents from the brown alga.展开更多
文摘Four polyphenols were isolated and purified from a brown alga </span><i><span style="font-family:Verdana;">Eisenia arborea</span></i><span style="font-family:Verdana;">. These phlorotannin compounds showed strong radical scavenging and some enzyme inhibitory activities. All of the compounds showed strong antioxidative, acetylcholinesterase and butyrylcholinesterase inhibitory, and tyrosinase inhbibitory activities at 100 μg/mL. Dieckol and PFF inhibited butyrylcholinesterase, a new target for the treatment of Alzheimer’s disease, very strongly even at 10 μg/mL</span></span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> more strongly than AChE. These two compounds also effectively inhibited tyrosinase. These results support the potential of developing natural antioxidants and antidementia agents from the brown alga.
