In order to gain further insight on the role of Kaposi’ s sarcoma associated herpesvirus (KSHV) in classic and endemic Kaposi’ s sarcoma (KS) pathogenesis, we aimed to determine (i) whether KSHV is detectable in p...In order to gain further insight on the role of Kaposi’ s sarcoma associated herpesvirus (KSHV) in classic and endemic Kaposi’ s sarcoma (KS) pathogenesis, we aimed to determine (i) whether KSHV is detectable in peripheral blood mononuclear cells (PBMCs), (ii) which PBMCs subpopulation harbor the virus, (iii) which clinical, histologic, and immunologic parameters are associated with KSHV viremia in a population of classic and endemic KS. KSHV viremia and various immunologic parameters were screened on 81 patients. KSHV viremia was positive in 58% of the patients. KSHV was detected in B cells, T cells, and monocytes. CD34+ cells depleted in circulating endothelial cells (CECs) were never infected and 50% of the patients tested had CECs infected by KSHV. We observed a significant increase of IL-2 and IFN-γ production by CD4 T cells and an increase of IFN-γ production by CD8 T cells compared to control patients. KS progression (P=0.001) and KS staging (P=0.03) were significantly and independently associated with positive KSHV viremia. Our results show that there is no specific immunosuppression in classic or endemic KS. We showed that KSHV can be detected within CECs and that KSHV viremia could be an indicator of circulating mature or precursor spindle cells.展开更多
Background: Systemic capillary leak syndrome (SCLS) is a severe disorder characterized by unexplained rapid transferof considerable volumes of plasma from the intravascular to the extravascular compartment. For some c...Background: Systemic capillary leak syndrome (SCLS) is a severe disorder characterized by unexplained rapid transferof considerable volumes of plasma from the intravascular to the extravascular compartment. For some cases of SCLS, no aetiology is evident and these cases are reported as idiopathic (ISCLS). Objectives: To describe the cutaneous findings in 3 patients with ISCLS. Results: Cutaneous involvement consisted in sclerosis, livedo, purpura and photodistributed maculopapular erythematous rash. Dermal mucinosis was proven by biopsy in 1 patient. No underlying disease was diagnosed during follow-up. Conclusion: The above-mentioned cutaneous findings can be present during acute attacks of ISCLS.They seem specifically related to the ISCLS and not indicative of an underlying disease.展开更多
文摘In order to gain further insight on the role of Kaposi’ s sarcoma associated herpesvirus (KSHV) in classic and endemic Kaposi’ s sarcoma (KS) pathogenesis, we aimed to determine (i) whether KSHV is detectable in peripheral blood mononuclear cells (PBMCs), (ii) which PBMCs subpopulation harbor the virus, (iii) which clinical, histologic, and immunologic parameters are associated with KSHV viremia in a population of classic and endemic KS. KSHV viremia and various immunologic parameters were screened on 81 patients. KSHV viremia was positive in 58% of the patients. KSHV was detected in B cells, T cells, and monocytes. CD34+ cells depleted in circulating endothelial cells (CECs) were never infected and 50% of the patients tested had CECs infected by KSHV. We observed a significant increase of IL-2 and IFN-γ production by CD4 T cells and an increase of IFN-γ production by CD8 T cells compared to control patients. KS progression (P=0.001) and KS staging (P=0.03) were significantly and independently associated with positive KSHV viremia. Our results show that there is no specific immunosuppression in classic or endemic KS. We showed that KSHV can be detected within CECs and that KSHV viremia could be an indicator of circulating mature or precursor spindle cells.
文摘Background: Systemic capillary leak syndrome (SCLS) is a severe disorder characterized by unexplained rapid transferof considerable volumes of plasma from the intravascular to the extravascular compartment. For some cases of SCLS, no aetiology is evident and these cases are reported as idiopathic (ISCLS). Objectives: To describe the cutaneous findings in 3 patients with ISCLS. Results: Cutaneous involvement consisted in sclerosis, livedo, purpura and photodistributed maculopapular erythematous rash. Dermal mucinosis was proven by biopsy in 1 patient. No underlying disease was diagnosed during follow-up. Conclusion: The above-mentioned cutaneous findings can be present during acute attacks of ISCLS.They seem specifically related to the ISCLS and not indicative of an underlying disease.
