目的:探究氨甲环酸不同给药途径联合大光斑低能量Q开关Nd:YAG激光治疗黄褐斑的治疗效果。方法:随机选取笔者科室2019年9月-2020年9月收治的81例黄褐斑患者为研究对象,按照随机数字表法分为两组。对照组(n=40)给予口服氨甲环酸片联合大...目的:探究氨甲环酸不同给药途径联合大光斑低能量Q开关Nd:YAG激光治疗黄褐斑的治疗效果。方法:随机选取笔者科室2019年9月-2020年9月收治的81例黄褐斑患者为研究对象,按照随机数字表法分为两组。对照组(n=40)给予口服氨甲环酸片联合大光斑低能量Q开关Nd:YAG激光治疗;观察组(n=41)给予氨甲环酸巴布剂贴敷联合大光斑低能量Q开关Nd:YAG激光治疗,比较两组临床疗效、临床症状[黄褐斑皮损面积和严重指数评分表(Melasma area severity index,MASI)],生活质量[皮肤病生活质量指数(Dermatology life quality index,DLQI)、黄褐斑生活质量评分量表(Melasma quality of life scale,MELASQOL)]及不良反应。结果:观察组总有效率为87.80%,对照组为65.85%,两组比较差异有统计学意义(P<0.05);治疗4个月后,两组MASI、DLQI、MELASQOL评分均显著降低(P<0.05),且治疗后组间比较差异有统计学意义(P<0.05);观察组不良反应总发生率为7.32%,对照组为17.50%,两组比较差异无统计学意义(P>0.05);治疗后随访6个月,观察组复发率为2.44%,对照组为7.50%,两组比较差异无统计学意义(χ^(2)=0.475,P>0.05)。结论:氨甲环酸巴布剂贴敷联合大光斑低能量Q开关Nd:YAG激光治疗黄褐斑疗效更佳,治疗后患者面部皮损改善效果更为显著,不良反应发生率及复发率均较低,值得临床推广应用。展开更多
肝内胆管缺失是指肝内胆管数量的减少或消失,是胆管树基本病理改变之一。免疫紊乱、肿瘤、感染、药物、缺血、遗传等因素都有可能引起胆管缺失。临床上,通过肝活组织检查,在10个及以上门管区的标本里,发现50%以上的小叶间胆管缺失,即可...肝内胆管缺失是指肝内胆管数量的减少或消失,是胆管树基本病理改变之一。免疫紊乱、肿瘤、感染、药物、缺血、遗传等因素都有可能引起胆管缺失。临床上,通过肝活组织检查,在10个及以上门管区的标本里,发现50%以上的小叶间胆管缺失,即可确诊[1]。胆管缺失的预后取决于病因和损伤程度。晚期出现不可逆的广泛胆管缺失甚至胆管消失时,该病理综合征称为胆管消失综合征(vanishing bile duct syndrome,VBDS),仅发生在0.5%小胆管病[2]。随后,可进展至广泛的胆管纤维化或肝硬化。有趣的是,也有部分患者表现为胆管上皮细胞再生,在数月或数年后得到恢复。本文总结了胆管缺失发病的分子机制,并重点强调近年来免疫介导的胆管病和胆管缺失的研究进展。展开更多
Cell death is typically defined either as apoptosis or necrosis. Because the consequences of apoptosis and necrosis are quite different for an entire organism, the investigation of the cell-death-mode switch has consi...Cell death is typically defined either as apoptosis or necrosis. Because the consequences of apoptosis and necrosis are quite different for an entire organism, the investigation of the cell-death-mode switch has considerable clinical significance. The existence of a necrosis-to-apoptosis switch induced by hydrogen peroxide in macrophage cell line RAW 264.7 cells was confirmed by using flow cytometry and fluorescence microscopy. With the help of computational simulations, this study predicted that negative feedbacks between NF-κB and MAPKs are implicated in converting necrosis into apoptosis in macrophages exposed to hydrogen peroxide, which has significant implications.展开更多
文摘目的:探究氨甲环酸不同给药途径联合大光斑低能量Q开关Nd:YAG激光治疗黄褐斑的治疗效果。方法:随机选取笔者科室2019年9月-2020年9月收治的81例黄褐斑患者为研究对象,按照随机数字表法分为两组。对照组(n=40)给予口服氨甲环酸片联合大光斑低能量Q开关Nd:YAG激光治疗;观察组(n=41)给予氨甲环酸巴布剂贴敷联合大光斑低能量Q开关Nd:YAG激光治疗,比较两组临床疗效、临床症状[黄褐斑皮损面积和严重指数评分表(Melasma area severity index,MASI)],生活质量[皮肤病生活质量指数(Dermatology life quality index,DLQI)、黄褐斑生活质量评分量表(Melasma quality of life scale,MELASQOL)]及不良反应。结果:观察组总有效率为87.80%,对照组为65.85%,两组比较差异有统计学意义(P<0.05);治疗4个月后,两组MASI、DLQI、MELASQOL评分均显著降低(P<0.05),且治疗后组间比较差异有统计学意义(P<0.05);观察组不良反应总发生率为7.32%,对照组为17.50%,两组比较差异无统计学意义(P>0.05);治疗后随访6个月,观察组复发率为2.44%,对照组为7.50%,两组比较差异无统计学意义(χ^(2)=0.475,P>0.05)。结论:氨甲环酸巴布剂贴敷联合大光斑低能量Q开关Nd:YAG激光治疗黄褐斑疗效更佳,治疗后患者面部皮损改善效果更为显著,不良反应发生率及复发率均较低,值得临床推广应用。
文摘肝内胆管缺失是指肝内胆管数量的减少或消失,是胆管树基本病理改变之一。免疫紊乱、肿瘤、感染、药物、缺血、遗传等因素都有可能引起胆管缺失。临床上,通过肝活组织检查,在10个及以上门管区的标本里,发现50%以上的小叶间胆管缺失,即可确诊[1]。胆管缺失的预后取决于病因和损伤程度。晚期出现不可逆的广泛胆管缺失甚至胆管消失时,该病理综合征称为胆管消失综合征(vanishing bile duct syndrome,VBDS),仅发生在0.5%小胆管病[2]。随后,可进展至广泛的胆管纤维化或肝硬化。有趣的是,也有部分患者表现为胆管上皮细胞再生,在数月或数年后得到恢复。本文总结了胆管缺失发病的分子机制,并重点强调近年来免疫介导的胆管病和胆管缺失的研究进展。
基金supported by the National Natural Science Foundation of China (Grant No. 30870588)the Science Fund for Creative Research Groups (Grant No. 30821006)the Program for New Century Excellent Talents in University (Grant No. NCET-06-0445)
文摘Cell death is typically defined either as apoptosis or necrosis. Because the consequences of apoptosis and necrosis are quite different for an entire organism, the investigation of the cell-death-mode switch has considerable clinical significance. The existence of a necrosis-to-apoptosis switch induced by hydrogen peroxide in macrophage cell line RAW 264.7 cells was confirmed by using flow cytometry and fluorescence microscopy. With the help of computational simulations, this study predicted that negative feedbacks between NF-κB and MAPKs are implicated in converting necrosis into apoptosis in macrophages exposed to hydrogen peroxide, which has significant implications.
