Glioblastoma multiforme(GBM),the most common and aggressive primary brain tumor in adults,is the most malignant and still has no cure.However,the novel role of long non-coding RNAs(lncRNAs)in the pathogenesis of gliob...Glioblastoma multiforme(GBM),the most common and aggressive primary brain tumor in adults,is the most malignant and still has no cure.However,the novel role of long non-coding RNAs(lncRNAs)in the pathogenesis of glioblastoma is attracting extensive attention.LncRNAs are transcribed RNA molecules over 200 nucleotides long that do not encode proteins.Unlike small non-coding RNAs,such as microRNAs(miRNAs),lncRNAs have more complex secondary and tertiary structures that enable them to interact with DNA,RNA,and proteins and perform multiple regulatory functions.LncRNAs act as molecular sponges,absorbing and sequestering other biomolecules,particularly miRNAs,thereby preventing these molecules from performing their normal functions.LncRNAs influence glioblastoma through gene expression regulation,molecular sponge capacity,epigenetic modulation,and signaling pathway interactions.In glioblastoma,a large number of lncRNAs have been found to be abnormally expressed,affecting tumor growth,invasion and resistance to treatment.Due to its regulatory role and disease-specific expression patterns,lncRNA has become a potential biomarker for glioblastoma and a promising new therapeutic target.This paper discusses the spongy role of lncRNAs in glioblastoma and its potential therapeutic applications,which will lay a foundation for our understanding of glioblastoma biology and the development of new diagnostic and therapeutic strategies in the future.展开更多
A double active center system, namely Salen-Cu（Ⅱ）@MIL-101（Cr）, was successfully synthesized via the"ship in a bottle" approach, which acted as a bifunctional material for both capture and conversion of ...A double active center system, namely Salen-Cu（Ⅱ）@MIL-101（Cr）, was successfully synthesized via the"ship in a bottle" approach, which acted as a bifunctional material for both capture and conversion of COin a single process. For the first time, Salen-Cu（Ⅱ）@MIL-101（Cr） catalyst was developed for the synthesis of propylene carbonate from COand propylene oxide under room temperature and ambient pressure with a yield of 87.8% over 60 h. Furthermore, the reaction mechanism was also discussed.展开更多
基金The study is funded by Binzhou Medical University Research Fund Project(Grant Number BY2021KYQD02).
文摘Glioblastoma multiforme(GBM),the most common and aggressive primary brain tumor in adults,is the most malignant and still has no cure.However,the novel role of long non-coding RNAs(lncRNAs)in the pathogenesis of glioblastoma is attracting extensive attention.LncRNAs are transcribed RNA molecules over 200 nucleotides long that do not encode proteins.Unlike small non-coding RNAs,such as microRNAs(miRNAs),lncRNAs have more complex secondary and tertiary structures that enable them to interact with DNA,RNA,and proteins and perform multiple regulatory functions.LncRNAs act as molecular sponges,absorbing and sequestering other biomolecules,particularly miRNAs,thereby preventing these molecules from performing their normal functions.LncRNAs influence glioblastoma through gene expression regulation,molecular sponge capacity,epigenetic modulation,and signaling pathway interactions.In glioblastoma,a large number of lncRNAs have been found to be abnormally expressed,affecting tumor growth,invasion and resistance to treatment.Due to its regulatory role and disease-specific expression patterns,lncRNA has become a potential biomarker for glioblastoma and a promising new therapeutic target.This paper discusses the spongy role of lncRNAs in glioblastoma and its potential therapeutic applications,which will lay a foundation for our understanding of glioblastoma biology and the development of new diagnostic and therapeutic strategies in the future.
基金supported by the National Key Projects for Fundamental R&D Program of China(2016YFB0600902)the NFSC of Tianjin(16JCZDJC36700 and 14JCQNJC03000)
文摘A double active center system, namely Salen-Cu（Ⅱ）@MIL-101（Cr）, was successfully synthesized via the"ship in a bottle" approach, which acted as a bifunctional material for both capture and conversion of COin a single process. For the first time, Salen-Cu（Ⅱ）@MIL-101（Cr） catalyst was developed for the synthesis of propylene carbonate from COand propylene oxide under room temperature and ambient pressure with a yield of 87.8% over 60 h. Furthermore, the reaction mechanism was also discussed.
