The authors investigated an aniline-catalyzed method to accelerate the reaction between equimolar reducing glycans and hydroxylamines. The rate-constants determined by real-time NMR were associated with the equivalenc...The authors investigated an aniline-catalyzed method to accelerate the reaction between equimolar reducing glycans and hydroxylamines. The rate-constants determined by real-time NMR were associated with the equivalence ratio of aniline rather than the concentration. Conjugates of oligosaccharide with hydroxylamine can be obtained in high efficiency at pH=5.4.展开更多
基金Supported by the National Natural Science Foundation of China(Nos.2007CB914403, 50803029)the Natural Science Foundation of Tianjin City, China(No.10JCYBJC04100)the Fundamental Research Funds for the Central Universities of China
文摘The authors investigated an aniline-catalyzed method to accelerate the reaction between equimolar reducing glycans and hydroxylamines. The rate-constants determined by real-time NMR were associated with the equivalence ratio of aniline rather than the concentration. Conjugates of oligosaccharide with hydroxylamine can be obtained in high efficiency at pH=5.4.
