目的探索程序性细胞死亡蛋白4(PDCD4)在脑出血(ICH)后血肿周围域的表达、作用及机制,为ICH疾病的后期康复治疗提供分子靶点。方法 Western blot、免疫组织化学检测蛋白质的表达变化;免疫荧光技术检测蛋白质的空间定位情况;siRNA转染进...目的探索程序性细胞死亡蛋白4(PDCD4)在脑出血(ICH)后血肿周围域的表达、作用及机制,为ICH疾病的后期康复治疗提供分子靶点。方法 Western blot、免疫组织化学检测蛋白质的表达变化;免疫荧光技术检测蛋白质的空间定位情况;siRNA转染进行细胞内蛋白质的干预。结果 PDCD4在大鼠ICH后血肿周围组织中表达上调,最高点位于ICH后第2天;上调的PDCD4主要与神经元Neu N存在共定位,并且与上调的凋亡蛋白活化Caspase-3之间也存在共定位;体外ICH模型中(即hemin诱导的神经元凋亡模型),通过siRNA靶向干预PDCD4的表达,则活化caspase-3明显降低,而存活因子p-Akt上调。结论 ICH后血肿周围域PDCD4的表达上调与神经元的凋亡相关,并且是通过p-Akt通路发挥作用的。展开更多
Escape time algorithm is an effective theoretical algorithm of constructing fractal graphics. The key of this algorithm lies in the construction of escape time function. A new escape time function is presented based o...Escape time algorithm is an effective theoretical algorithm of constructing fractal graphics. The key of this algorithm lies in the construction of escape time function. A new escape time function is presented based on the research of escape time algorithm. An accelerated escape time algorithm is carried out in this paper. The experiments have demonstrated that the new algorithm is not only as precise as the old, but also faster when it is used to construct Julia set.展开更多
By a novel controlled combustion synthesis method, a large amount of ZnO nano-whiskers with different morphologies like nanotetrapods, long-leg nanotetrapod and multipods, were prepared without any catalysts and addit...By a novel controlled combustion synthesis method, a large amount of ZnO nano-whiskers with different morphologies like nanotetrapods, long-leg nanotetrapod and multipods, were prepared without any catalysts and additives in open air at high temperature. Their morphologies, structures and optical properties were in-vestigated by using SEM, XRD and PL spectrum. The possible growth mechanisms on the ZnO nano-whiskers were proposed in this paper.展开更多
文摘Escape time algorithm is an effective theoretical algorithm of constructing fractal graphics. The key of this algorithm lies in the construction of escape time function. A new escape time function is presented based on the research of escape time algorithm. An accelerated escape time algorithm is carried out in this paper. The experiments have demonstrated that the new algorithm is not only as precise as the old, but also faster when it is used to construct Julia set.
基金the National Natural Science Foundation of China (Grant Nos. 50572010, 50742007 and 10672020)National Defense Founds of China (Grant Nos. 51420205BQ0154 and A2220061080)+1 种基金"863" Project of China (Grant No. 2007AA03Z103)the Scientific Research Foun-dation of Graduate School of BIT (Grant No. AA200802)
文摘By a novel controlled combustion synthesis method, a large amount of ZnO nano-whiskers with different morphologies like nanotetrapods, long-leg nanotetrapod and multipods, were prepared without any catalysts and additives in open air at high temperature. Their morphologies, structures and optical properties were in-vestigated by using SEM, XRD and PL spectrum. The possible growth mechanisms on the ZnO nano-whiskers were proposed in this paper.
