针对尾矿坝在线监测重建设、轻利用的现状,基于尾矿坝位移在线监测时间序列,通过多步逆向云变换算法(Multi-step Backward Cloud Transformation Algorithm Based on Sampling with Replacement,MBCT-SR)改进云模型,根据“3E_(n)原则”...针对尾矿坝在线监测重建设、轻利用的现状,基于尾矿坝位移在线监测时间序列,通过多步逆向云变换算法(Multi-step Backward Cloud Transformation Algorithm Based on Sampling with Replacement,MBCT-SR)改进云模型,根据“3E_(n)原则”和内外包络曲线确定在线监测位移的正常运行值,从而建立尾矿坝位移分级预警阈值模型,并利用某尾矿坝全球导航卫星(Global Navigation Satellite System,GNSS)技术表面位移在线监测数据进行实例验证。结果表明:该尾矿坝水平方向位移的黄、橙、红预警阈值分别为8.41 mm/d、12.94 mm/d、19.41 mm/d,呈现出坝体中间预警阈值最大、并由中间向两侧减小的空间变化规律;尾矿坝垂直方向位移的黄、橙、红预警阈值分别为16.56 mm/d、25.48 mm/d、38.22 mm/d,且随着子坝的堆积,预警阈值逐渐增大。展开更多
OBJECTIVE:To evaluate the efficacy of Baishao Luoshi decoction(白芍络石方,BD)on synaptic plasticity in rats with post stroke spasticity(PSS),and to study the mechanism behind the action.METHODS:The PSS model of rat wa...OBJECTIVE:To evaluate the efficacy of Baishao Luoshi decoction(白芍络石方,BD)on synaptic plasticity in rats with post stroke spasticity(PSS),and to study the mechanism behind the action.METHODS:The PSS model of rat was established by middle cerebral artery occlusion(MCAO).The neurological deficit symptoms were evaluated by modified neurological deficit score(mN SS).Muscle tension were evaluated by Modified Ashworth score(MAS).Transmission electron microscopy(TEM)was used to observe the synaptic ultrastructure.The expression of synaptic plasticity-related protein brain derived neurotrophic factor(BDNF),growth associated protein-43(GAP43),synaptophysin(p38)and microtubule-associated protein 2(MAP2)in the brain tissue around the infarct were detected by Western blotting.RESULTS:We found that mNSS were significantly improved and limb spasticity was ameliorated treated by BD.The thickness of postsynaptic density and the synaptic curvature increased significantly.The expression of synaptic plasticity-related protein BDNF,GAP43,p38,MAP2 in the brain tissue around the infarct were raised remarkably after treated by BD.CONCLUSIONS:Alleviating PSS by BD may be related to rescuing the synaptic plasticity,which provides a probable new therapeutic method for PSS.展开更多
基金Supported by the China Postdoctoral Science Foundation:Research on the Mechanism of Baishaoluoshi Decoction in Improving Poststroke Spasticity by KCC2-GABAAR Based on the Theory of“Gan Zhu Jin”(No.2020M682571)Natural Science Foundation of Hunan Province China:Research on the Mechanism of Post-stroke Spasticity by KCC2--GABAAR-Motoneuron Excitability and Chinese Traditional Medicine Intervention Based on the Theory of“Gan Zhu Jin”(No.2019JJ50343)the Scientific Research Project of Education Department of Hunan Province:Research on the Mechanism of Axonal Regeneration and TCM Intervention in Post-Stroke Spasticity Based on the Theory of“Gan Zhu Jin”by Slit-Robo Pathway(No.19C1423)。
文摘OBJECTIVE:To evaluate the efficacy of Baishao Luoshi decoction(白芍络石方,BD)on synaptic plasticity in rats with post stroke spasticity(PSS),and to study the mechanism behind the action.METHODS:The PSS model of rat was established by middle cerebral artery occlusion(MCAO).The neurological deficit symptoms were evaluated by modified neurological deficit score(mN SS).Muscle tension were evaluated by Modified Ashworth score(MAS).Transmission electron microscopy(TEM)was used to observe the synaptic ultrastructure.The expression of synaptic plasticity-related protein brain derived neurotrophic factor(BDNF),growth associated protein-43(GAP43),synaptophysin(p38)and microtubule-associated protein 2(MAP2)in the brain tissue around the infarct were detected by Western blotting.RESULTS:We found that mNSS were significantly improved and limb spasticity was ameliorated treated by BD.The thickness of postsynaptic density and the synaptic curvature increased significantly.The expression of synaptic plasticity-related protein BDNF,GAP43,p38,MAP2 in the brain tissue around the infarct were raised remarkably after treated by BD.CONCLUSIONS:Alleviating PSS by BD may be related to rescuing the synaptic plasticity,which provides a probable new therapeutic method for PSS.
