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微小肝癌早期诊断关键分子的研究进展 被引量:3
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作者 杨静 曹宪炳 +4 位作者 连镇炎 周旭洋 张诗雨 曾宁 方驰华 《分子影像学杂志》 2020年第4期621-624,共4页
肝癌是消化系统的常见恶性肿瘤之一,因大多数患者在肝癌早期并无临床症状,在就诊时已多是晚期,死亡率高特点决定了早期诊断和早期治疗是提高生存率最有效手段。如何提高微小肝癌的早期诊断成为我们亟待解决的重要问题,而微小肝癌早期新... 肝癌是消化系统的常见恶性肿瘤之一,因大多数患者在肝癌早期并无临床症状,在就诊时已多是晚期,死亡率高特点决定了早期诊断和早期治疗是提高生存率最有效手段。如何提高微小肝癌的早期诊断成为我们亟待解决的重要问题,而微小肝癌早期新生血管关键分子则成为早期诊断至关重要的一步。本文通过查阅近几年国内外相关文献,对部分微小肝癌早期诊断关键分子-Prox1、Glypican-3、上皮细胞黏附因子、趋化因子受体4的研究现状和不足进行综述,旨在为微小肝癌的早期筛查和诊断提供的新方向及思路。 展开更多
关键词 微小癌灶 早期诊断 肝癌 关键分子 肿瘤标志物
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吲哚菁绿荧光影像技术在肝胆胰外科疾病诊治中的应用进展 被引量:3
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作者 曹宪炳 连镇炎 +3 位作者 杨静 梁婉莹 曾宁 方驰华 《分子影像学杂志》 2020年第2期193-196,共4页
近年来,吲哚菁绿分子荧光影像技术在肝胆胰外科中的应用日益广泛,该技术应用日趋成熟,在肝胆胰外科围手术期中扮演着重要角色。吲哚菁绿在肝脏外科中的应用主要包括术前评估和术中进行微小癌灶的侦测、肿瘤边界界定和左右半肝界定,可使... 近年来,吲哚菁绿分子荧光影像技术在肝胆胰外科中的应用日益广泛,该技术应用日趋成熟,在肝胆胰外科围手术期中扮演着重要角色。吲哚菁绿在肝脏外科中的应用主要包括术前评估和术中进行微小癌灶的侦测、肿瘤边界界定和左右半肝界定,可使肝切除手术更为精准、安全,尤其是在肿瘤切除术中可以有效减低手术风险并提高R0切除率;在胆道外科中对肝内胆管癌、胆囊切除和胰腺肿瘤的应用较为广泛,可避免胆道的损伤和提高胰腺肿瘤的诊治效果。故本文通过查阅近几年国内外关于吲哚菁绿在肝胆胰外科应用的研究成果,如在肝切除术前评估肝脏功能,在肝切除术中用于侦测肝断面边缘残余肿瘤及术中微小癌灶,以及在肝肿瘤边界、左右半肝界定、腹腔镜胆囊切除术、肝内胆管癌、胰腺外科等中的应用,标题全方位地阐述吲哚菁绿分子荧光影像技术在肝胆胰外科疾病中的相关应用。 展开更多
关键词 吲哚菁绿 肝体积 微小癌灶 肝肿瘤边界 肝切除
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Distributed Heterogeneous Multi-Agent Optimization with Stochastic Sub-Gradient
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作者 HU Haokun MO Lipo cao xianbing 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2024年第4期1470-1487,共18页
This paper studies the optimization problem of heterogeneous networks under a timevarying topology.Each agent only accesses to one local objective function,which is nonsmooth.An improved algorithm with noisy measureme... This paper studies the optimization problem of heterogeneous networks under a timevarying topology.Each agent only accesses to one local objective function,which is nonsmooth.An improved algorithm with noisy measurement of local objective functions' sub-gradients and additive noises among information exchanging between each pair of agents is designed to minimize the sum of objective functions of all agents.To weaken the effect of these noises,two step sizes are introduced in the control protocol.By graph theory,stochastic analysis and martingale convergence theory,it is proved that if the sub-gradients are uniformly bounded,the sequence of digraphs is balanced and the union graph of all digraphs is joint strongly connected,then the designed control protocol can force all agents to find the global optimal point almost surely.At last,the authors give some numerical examples to verify the effectiveness of the stochastic sub-gradient algorithms. 展开更多
关键词 Communication noises distributed stochastic optimization heterogeneous networks subgradient measurement noises
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Fractional-Order Model of the Disease Psoriasis:A Control Based Mathematical Approach 被引量:4
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作者 cao xianbing DATTA Abhirup +1 位作者 AL BASIR Fahad ROY Priti Kumar 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2016年第6期1565-1584,共20页
Autoimmune diseases are generated through irregular immune response of the human body. Psoriasis is one type of autoimmune chronic skin diseases that is differentiated by T-Cells mediated hyper-proliferation of epider... Autoimmune diseases are generated through irregular immune response of the human body. Psoriasis is one type of autoimmune chronic skin diseases that is differentiated by T-Cells mediated hyper-proliferation of epidermal Keratinocytes. Dendritic Cells and CD8+ T-Cells have a significant role for the occurrence of this disease. In this paper, the authors have developed a mathematical model of Psoriasis involving CD4+ T-Cells, Dendritic Ceils, CD8+ T-Cells and Keratinocyte cell populations using the fractional differential equations with the effect of Cytokine release to observe the impact of memory on the cell-biological system. Using fractional calculus, the authors try to explore the suppressed memory, associated with the cell-biological system and to locate the position of Keratinocyte cell population as fractional derivative possess non-local property. Thus, the dynamics of Psoriasis can be predicted in a better way using fractional differential equations rather than its corresponding integer order model. Finally, the authors introduce drug into the system to obstruct the interaction between CD4+ T-Cells and Keratinocytes to restrict the disease Psoriasis. The authors derive the Euler-Lagrange conditions for the optimality made through Matlab by developing iterative of the drug induced system. Numerical simulations are schemes. 展开更多
关键词 Fractional differential equations (FDEs) MEMORY optimal control problem pMHC Pso-riasis.
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Distributed Second-Order Continuous-Time Optimization via Adaptive Algorithm with Nonuniform Gradient Gains 被引量:3
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作者 MO Lipo LIU Xiaodong +1 位作者 cao xianbing YU Yongguang 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2020年第6期1914-1932,共19页
This paper addresses the distributed adaptive optimization problem over second-order multi-agent networks(MANs)with nonuniform gradient gains.A general convex function consisting of a sum of local differentiable conve... This paper addresses the distributed adaptive optimization problem over second-order multi-agent networks(MANs)with nonuniform gradient gains.A general convex function consisting of a sum of local differentiable convex functions is chosen as the team objective function.First,based on the local information of each agent’s neighborhood,a novel distributed adaptive optimization algorithm with nonuniform gradient gains is designed,where these gains only have relations with agents’own states.And then,the original closed-loop system is changed into an equivalent one by taking a coordination transformation.Moreover,it is proved that the states including positions and velocities of all agents are bounded by constructing a Lyapunov function provided that the initial values are given.By the theory of Lyapunov stability,it is shown that all agents can finally reach an agreement and their position states converge to the optimal solution of the team objective function asymptotically.Finally,the effectiveness of the obtained theoretical results is demonstrated by several simulation examples. 展开更多
关键词 Adaptive CONSENSUS distributed optimization nonuniform gradient gains second-order dynamics
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