OBJECTIVE:To assess the lipid-lowering activity and safety of a dietary supplement containing monacolin Kβ-hydroxy acid form(MKA),Heye(Folium Nelumbinis),and Cangzhu(Rhizoma Atractylodis Lanceae),compared to lifestyl...OBJECTIVE:To assess the lipid-lowering activity and safety of a dietary supplement containing monacolin Kβ-hydroxy acid form(MKA),Heye(Folium Nelumbinis),and Cangzhu(Rhizoma Atractylodis Lanceae),compared to lifestyle modifications.METHODS:Totally 117 subjects with moderate to severe dyslipidemia(according to Chinese guidelines)and low CV risk were randomly assigned into three treatment groups:lifestyle modification(LM),LM plus a low dosage of MKA,LM plus a high dosage of MKA,and treated for 60 d.The primary endpoint was the reduction of low density lipoprotein cholesterol(LDL-C)and total cholesterol(TC).Safeties along with Traditional Chinese Medicine Syndromes were assessed through the study.RESULTS:A low dosage of MKA along with lifestyle modifications caused a significant decrease in LDL-C by 15.6%on average(95%CI,9.6%to 21%)with,a decrease in TC by 15.3%on average(95%CI,9.26%to 21.4%),and a decrease in non-HDL-C by 35.4%(95%CI,25.76%to 41.34%).Weak evidence of a reduction of triglycerides but an increment of HDL-C was observed in patients with severe hyperlipidemia.No severe adverse events occurred during the study.CONCLUSION:Our results confirm the LDL-C and TC lowering properties of MKA is clinically meaningful.It also produces a significant reduction of non-HDL-C,and slightly effects on TG and HDL-C as well.展开更多
In wireless sensor networks,data fusion(in-network processing)is a critical issue because sensor networks are energy-constrained and bandwidth-constrained.Recently,a new scheme based on mobile agent has been proposed ...In wireless sensor networks,data fusion(in-network processing)is a critical issue because sensor networks are energy-constrained and bandwidth-constrained.Recently,a new scheme based on mobile agent has been proposed to solve the problem.The order and number of nodes on the route traversed by a mobile agent determine the energy consumption,and hence,they have a significant impact on the overall performance of the whole system.Considering the limited transmission range of sensor nodes,we showed that this routing problem in a multi-hop cluster could be modeled as a node-weighted traveling tourist problem(TTP).We proved that the problem was nondeterministic polynomial time(NP)-complete.Then we presented a new approximation algorithm to solve the problem.Simulation experiments demonstrate that the proposed heuristic is more energy-efficient than the two earlier ones.展开更多
基金Supported by Guangzhou Science and Technology Plan project(No.201710010107)Joint Innovation Specific Project in Key areas from Guangdong Branch Institute of China Academy of Chinese Medical Sciences(No.ZZ0908065)Project of Administration of Traditional Chinese Medicine of Guangdong Province of China(No.201811389)。
文摘OBJECTIVE:To assess the lipid-lowering activity and safety of a dietary supplement containing monacolin Kβ-hydroxy acid form(MKA),Heye(Folium Nelumbinis),and Cangzhu(Rhizoma Atractylodis Lanceae),compared to lifestyle modifications.METHODS:Totally 117 subjects with moderate to severe dyslipidemia(according to Chinese guidelines)and low CV risk were randomly assigned into three treatment groups:lifestyle modification(LM),LM plus a low dosage of MKA,LM plus a high dosage of MKA,and treated for 60 d.The primary endpoint was the reduction of low density lipoprotein cholesterol(LDL-C)and total cholesterol(TC).Safeties along with Traditional Chinese Medicine Syndromes were assessed through the study.RESULTS:A low dosage of MKA along with lifestyle modifications caused a significant decrease in LDL-C by 15.6%on average(95%CI,9.6%to 21%)with,a decrease in TC by 15.3%on average(95%CI,9.26%to 21.4%),and a decrease in non-HDL-C by 35.4%(95%CI,25.76%to 41.34%).Weak evidence of a reduction of triglycerides but an increment of HDL-C was observed in patients with severe hyperlipidemia.No severe adverse events occurred during the study.CONCLUSION:Our results confirm the LDL-C and TC lowering properties of MKA is clinically meaningful.It also produces a significant reduction of non-HDL-C,and slightly effects on TG and HDL-C as well.
基金supported by the National Natural Science Foundation of China(Grant No.60372076).
文摘In wireless sensor networks,data fusion(in-network processing)is a critical issue because sensor networks are energy-constrained and bandwidth-constrained.Recently,a new scheme based on mobile agent has been proposed to solve the problem.The order and number of nodes on the route traversed by a mobile agent determine the energy consumption,and hence,they have a significant impact on the overall performance of the whole system.Considering the limited transmission range of sensor nodes,we showed that this routing problem in a multi-hop cluster could be modeled as a node-weighted traveling tourist problem(TTP).We proved that the problem was nondeterministic polynomial time(NP)-complete.Then we presented a new approximation algorithm to solve the problem.Simulation experiments demonstrate that the proposed heuristic is more energy-efficient than the two earlier ones.
