目的系统评价取卵后使用来曲唑(LE)预防中重度卵巢过度刺激综合征(OHSS)的临床效果。方法通过计算机检索PubMed、Cochrane Library、Web of Science、Ovid、Embase、中国知网数据库(CNKI)和万方数据库,检索自建库至2020年6月发表的关于...目的系统评价取卵后使用来曲唑(LE)预防中重度卵巢过度刺激综合征(OHSS)的临床效果。方法通过计算机检索PubMed、Cochrane Library、Web of Science、Ovid、Embase、中国知网数据库(CNKI)和万方数据库,检索自建库至2020年6月发表的关于取卵后使用LE预防OHSS的临床效果研究,按照纳入和排除标准筛选文献。对于纳入研究进行质量评价并提取相关数据,采用RevMan 5.3和Stata 12.0软件进行Meta分析。结果最终共纳入符合标准的5篇文献,包括随机对照试验和前瞻性队列研究,共计671例OHSS高危患者。Meta分析结果显示:取卵后使用LE的患者中重度OHSS的发生率显著低于对照组,差异有统计学意义[OR=0.45,95%CI(0.31,0.65),P<0.0001]。结论取卵后使用LE可以显著降低中重度OHSS的发生率。展开更多
Some novel spiro-acetals of 5-trimethylsilylcyclohex-2(or 3)-enone were synthesized from the reaction of silylcyclohexenones with the corresponding a, ω-diols in the presence of oxalic acid or adipic acid.
In order to investigate the structure-odor relationship of odoriferous compounds and search for new aroma chemicals, seven acetals of 4-trimethylsilyl-3-cyclohexenone and their carbon counterparts were synthesized by ...In order to investigate the structure-odor relationship of odoriferous compounds and search for new aroma chemicals, seven acetals of 4-trimethylsilyl-3-cyclohexenone and their carbon counterparts were synthesized by Birch reduction of 4-substituted anisoles and then acetalization. Seven acetals of 4-trimethylsilylcyclohexanone and their carbon counterparts were synthesized similarly. Structures of all new compounds were determined by MS, IR and ~1H NMR, and their characteristic odors were evaluated as well. The characteristic odors of the acetals formed by 4-substituted-3-cyclohexenone and 1, 2-diols are fruity and woody. The acetals formed from 1, 3-diols are woody, and formed with 1, 4-diols are very faint in odor. Odors of acetals of 4-substituted cyclohexanone are all very weak. As a whole, odors of organosilicon compounds are weaker, but somewhat more delicate than their carbon counter- parts.展开更多
基金Supported by NSFC and Youth Foundation of Tianjin
文摘Some novel spiro-acetals of 5-trimethylsilylcyclohex-2(or 3)-enone were synthesized from the reaction of silylcyclohexenones with the corresponding a, ω-diols in the presence of oxalic acid or adipic acid.
基金Project supported by NSFCNational Laboratory of Elemento-Organic Chemistry.
文摘In order to investigate the structure-odor relationship of odoriferous compounds and search for new aroma chemicals, seven acetals of 4-trimethylsilyl-3-cyclohexenone and their carbon counterparts were synthesized by Birch reduction of 4-substituted anisoles and then acetalization. Seven acetals of 4-trimethylsilylcyclohexanone and their carbon counterparts were synthesized similarly. Structures of all new compounds were determined by MS, IR and ~1H NMR, and their characteristic odors were evaluated as well. The characteristic odors of the acetals formed by 4-substituted-3-cyclohexenone and 1, 2-diols are fruity and woody. The acetals formed from 1, 3-diols are woody, and formed with 1, 4-diols are very faint in odor. Odors of acetals of 4-substituted cyclohexanone are all very weak. As a whole, odors of organosilicon compounds are weaker, but somewhat more delicate than their carbon counter- parts.
