构建基于TOPSIS(technique for order preference by similarity to ideal solution)的最优组合权重赋权模型,对上海18个研发与转化功能性平台198项专利产出进行实证分析,研究创新点表现在两个方面:通过正负理想点构建优化的组合赋权模...构建基于TOPSIS(technique for order preference by similarity to ideal solution)的最优组合权重赋权模型,对上海18个研发与转化功能性平台198项专利产出进行实证分析,研究创新点表现在两个方面:通过正负理想点构建优化的组合赋权模型,避免了现有研究中没有考虑专利是否能够成功转化的弊端;通过中位数检验验证了平台效率评估模型的合理性,避免了现有研究忽略对平台专利转化效率测度模型合理性进行验证的缺陷。实证发现,该研究构建的组合赋权模型专利转化风险鉴别能力(Z=5.546)较高,可以较为科学地判定研发与转化功能性平台的实际效率。展开更多
3-酮脂酰辅酶A硫解酶(3-ketoacyl CoA thiolase,3-KAT)是一类在脂肪酸β-氧化裂解反应中扮演重要角色的酶,包括线粒体型和过氧化物酶体(peroxisome)型,二者分别由不同基因编码.在线粒体该酶催化中长链及短链脂肪酸彻底裂解为乙酰辅酶A;...3-酮脂酰辅酶A硫解酶(3-ketoacyl CoA thiolase,3-KAT)是一类在脂肪酸β-氧化裂解反应中扮演重要角色的酶,包括线粒体型和过氧化物酶体(peroxisome)型,二者分别由不同基因编码.在线粒体该酶催化中长链及短链脂肪酸彻底裂解为乙酰辅酶A;在过氧化物酶体其底物则为极长链脂肪酸(≥C22)、长链脂肪酸和支链脂肪酸,经过有限的β氧化循环,缩短碳链,之后产物进入线粒体继续氧化(图1).3-KAT是脂肪酸β-氧化最后一步,其活性的高低直接影响心肌对底物脂肪酸与糖的选择性及氧的利用效率.另在秀丽隐杆线虫观察到,该酶具有抗衰老作用,是去乙酰化酶Sirt2.1抗衰老的关键下游分子[1].3-KAT在机体中的重要性使得有必要多角度阐释其分子特征.展开更多
Ecological security is the foundation and guarantee of sustainable development,and its importance is increasingly widely recognized and valued by the world.The Yangtze River Basin is an important ecological security b...Ecological security is the foundation and guarantee of sustainable development,and its importance is increasingly widely recognized and valued by the world.The Yangtze River Basin is an important ecological security barrier in China and the Wanjiang City Belt(WCB)along the Yangtze River is directly related to the ecological security pattern of the entire basin.Based on the Driver-Pressure-State-Impact-Response(DPSIR)model and a geographical information system(GIS)platform,an ecosystem security evaluation index system was constructed to measure and evaluate the evolution of ecosystem security in the WCB,China.Results showed that:1)From 2000 to 2018,the overall level of ecological security in the study area was in a state of either early warning or medium warning,but the level of ecological security in each prefecture-level city was significantly different.2)From the perspective of the evolution of the ecosystem,the value of its comprehensive evaluation index dropped from 4.255 in 2000 to 3.885 in 2018.From the perspective of subsystems,the value of Pressure comprehensive evaluation index is much higher than that of other subsystems,indicating that during the rapid development of the social economy,the pressure on the natural environment tended to rise,and triggered changes in the State and Response subsystems.3)The coefficient of variation(CV)of the Driver was much higher than other factors influencing the ecological security system.There are large differences in the economic development and ecological evolution of the cities in the WCB.This study has improved the theoretical research on regional ecological security,and has certain practical guiding significance for building a beautiful,green and sustainable China and promoting global ecological security.展开更多
文摘构建基于TOPSIS(technique for order preference by similarity to ideal solution)的最优组合权重赋权模型,对上海18个研发与转化功能性平台198项专利产出进行实证分析,研究创新点表现在两个方面:通过正负理想点构建优化的组合赋权模型,避免了现有研究中没有考虑专利是否能够成功转化的弊端;通过中位数检验验证了平台效率评估模型的合理性,避免了现有研究忽略对平台专利转化效率测度模型合理性进行验证的缺陷。实证发现,该研究构建的组合赋权模型专利转化风险鉴别能力(Z=5.546)较高,可以较为科学地判定研发与转化功能性平台的实际效率。
文摘3-酮脂酰辅酶A硫解酶(3-ketoacyl CoA thiolase,3-KAT)是一类在脂肪酸β-氧化裂解反应中扮演重要角色的酶,包括线粒体型和过氧化物酶体(peroxisome)型,二者分别由不同基因编码.在线粒体该酶催化中长链及短链脂肪酸彻底裂解为乙酰辅酶A;在过氧化物酶体其底物则为极长链脂肪酸(≥C22)、长链脂肪酸和支链脂肪酸,经过有限的β氧化循环,缩短碳链,之后产物进入线粒体继续氧化(图1).3-KAT是脂肪酸β-氧化最后一步,其活性的高低直接影响心肌对底物脂肪酸与糖的选择性及氧的利用效率.另在秀丽隐杆线虫观察到,该酶具有抗衰老作用,是去乙酰化酶Sirt2.1抗衰老的关键下游分子[1].3-KAT在机体中的重要性使得有必要多角度阐释其分子特征.
基金Under the auspices of National Natural Science Foundation of China(No.41571124)。
文摘Ecological security is the foundation and guarantee of sustainable development,and its importance is increasingly widely recognized and valued by the world.The Yangtze River Basin is an important ecological security barrier in China and the Wanjiang City Belt(WCB)along the Yangtze River is directly related to the ecological security pattern of the entire basin.Based on the Driver-Pressure-State-Impact-Response(DPSIR)model and a geographical information system(GIS)platform,an ecosystem security evaluation index system was constructed to measure and evaluate the evolution of ecosystem security in the WCB,China.Results showed that:1)From 2000 to 2018,the overall level of ecological security in the study area was in a state of either early warning or medium warning,but the level of ecological security in each prefecture-level city was significantly different.2)From the perspective of the evolution of the ecosystem,the value of its comprehensive evaluation index dropped from 4.255 in 2000 to 3.885 in 2018.From the perspective of subsystems,the value of Pressure comprehensive evaluation index is much higher than that of other subsystems,indicating that during the rapid development of the social economy,the pressure on the natural environment tended to rise,and triggered changes in the State and Response subsystems.3)The coefficient of variation(CV)of the Driver was much higher than other factors influencing the ecological security system.There are large differences in the economic development and ecological evolution of the cities in the WCB.This study has improved the theoretical research on regional ecological security,and has certain practical guiding significance for building a beautiful,green and sustainable China and promoting global ecological security.
