Four ＂picket fence＂ porphyrin atropisomers were respectively synthesized from the four corresponding atropisomers of meso-tetra（o-aminophenyl）porphyrin that had been chromatographed on a column eluted with petrole...Four ＂picket fence＂ porphyrin atropisomers were respectively synthesized from the four corresponding atropisomers of meso-tetra（o-aminophenyl）porphyrin that had been chromatographed on a column eluted with petroleum ether and ethyl acetate. Results show that each atropisomer could be successfully synthesized by controlling the acylation temperature at 0 ℃. They were characterized by 1H NMR, HRMS, IR, UV-Vis and Langmuir-Blodgett（LB） film analyses. Although the results of HRMS, IR, UV-Vis analyses indicate there is no remarkable difference among the atropisomers, the results of the 1H NMR and the mean molecular areas obtained by LB film technique imply that the atropisomers are significantly discrepant. The former shows that the chemical shifts of the methyl and amide protons of each atropisomer are distinct, while the later presents that the different atropisomer molecules can occupy the different surface areas at the air/water interface.展开更多
目的探讨血清中IL-4、IL-6、TNF-α水平在儿童睡眠呼吸障碍中的价值。方法收集河南省人民医院和郑州大学第一附属医院2018年9月—2019年12月收治的68例儿童睡眠呼吸障碍资料,运用腺样体-鼻咽腔比比值,分为轻度阻塞组32例,中重度阻塞组36...目的探讨血清中IL-4、IL-6、TNF-α水平在儿童睡眠呼吸障碍中的价值。方法收集河南省人民医院和郑州大学第一附属医院2018年9月—2019年12月收治的68例儿童睡眠呼吸障碍资料,运用腺样体-鼻咽腔比比值,分为轻度阻塞组32例,中重度阻塞组36例,选取同期18例健康儿童为对照组。将轻度阻塞组、中重度阻塞组、对照组血清中IL-4、IL-6、TNF-α水平进行比较。结果轻度阻塞组血清中IL-4、IL-6、TNF-α水平显著高于对照组[3.71 vs 2.53;4.51 vs 3.44;4.86 vs 2.99,Z值分别为2.046;2.244;2.971,P<0.05],差异均有统计学意义;中重度阻塞组血清中IL-4、IL-6、TNF-α水平显著高于对照组[4.82 vs 2.53;5.53 vs 3.44;15.96 vs 2.99, Z值分别为3.028;3.936;8.332,P<0.05],差异均有统计学意义;中重度阻塞组血清中IL-6、TNF-α水平显著高于轻度阻塞组[5.53 vs 4.51;15.96 vs 4.86, Z值分别为2.027和4.681,P<0.05],差异均有统计学意义。结论血清中IL-4、IL-6、TNF-α水平升高有助于儿童睡眠呼吸障碍的诊断。展开更多
基金Supported by the National Natural Science Foundation of China(No.20806025)
文摘Four ＂picket fence＂ porphyrin atropisomers were respectively synthesized from the four corresponding atropisomers of meso-tetra（o-aminophenyl）porphyrin that had been chromatographed on a column eluted with petroleum ether and ethyl acetate. Results show that each atropisomer could be successfully synthesized by controlling the acylation temperature at 0 ℃. They were characterized by 1H NMR, HRMS, IR, UV-Vis and Langmuir-Blodgett（LB） film analyses. Although the results of HRMS, IR, UV-Vis analyses indicate there is no remarkable difference among the atropisomers, the results of the 1H NMR and the mean molecular areas obtained by LB film technique imply that the atropisomers are significantly discrepant. The former shows that the chemical shifts of the methyl and amide protons of each atropisomer are distinct, while the later presents that the different atropisomer molecules can occupy the different surface areas at the air/water interface.
文摘目的探讨血清中IL-4、IL-6、TNF-α水平在儿童睡眠呼吸障碍中的价值。方法收集河南省人民医院和郑州大学第一附属医院2018年9月—2019年12月收治的68例儿童睡眠呼吸障碍资料,运用腺样体-鼻咽腔比比值,分为轻度阻塞组32例,中重度阻塞组36例,选取同期18例健康儿童为对照组。将轻度阻塞组、中重度阻塞组、对照组血清中IL-4、IL-6、TNF-α水平进行比较。结果轻度阻塞组血清中IL-4、IL-6、TNF-α水平显著高于对照组[3.71 vs 2.53;4.51 vs 3.44;4.86 vs 2.99,Z值分别为2.046;2.244;2.971,P<0.05],差异均有统计学意义;中重度阻塞组血清中IL-4、IL-6、TNF-α水平显著高于对照组[4.82 vs 2.53;5.53 vs 3.44;15.96 vs 2.99, Z值分别为3.028;3.936;8.332,P<0.05],差异均有统计学意义;中重度阻塞组血清中IL-6、TNF-α水平显著高于轻度阻塞组[5.53 vs 4.51;15.96 vs 4.86, Z值分别为2.027和4.681,P<0.05],差异均有统计学意义。结论血清中IL-4、IL-6、TNF-α水平升高有助于儿童睡眠呼吸障碍的诊断。
