Biomonitoring human exposed to alkylating agents with theSister Chromatid Exchanges assay(SCEs)and especially theHigh Frequency Cells concept(HFCs)is considered as asensitive approach for detecting a personal exposure...Biomonitoring human exposed to alkylating agents with theSister Chromatid Exchanges assay(SCEs)and especially theHigh Frequency Cells concept(HFCs)is considered as asensitive approach for detecting a personal exposure.Six yearsafter a two-year chronic exposure of primates to EtO,a highlymutagenic agent,an persistently increased SCEs frequency hasrecently been published.In this experiment,the appearance of ahighly mutated subpopulation of cells(the High Frequency展开更多
Biomonitoring with cytogenetic methods consistto compare a known or suspected exposed groups with acontrol group with different endpoints.Generallyfactors which may influence the baseline levels ofsister chromatid exc...Biomonitoring with cytogenetic methods consistto compare a known or suspected exposed groups with acontrol group with different endpoints.Generallyfactors which may influence the baseline levels ofsister chromatid exchanges frequency fall in 2 cate-gories:technical and biological factors.In additionto age,sex,drug use,smoking habits,health statusmight also be relevant.During a long term survey ofpeople professionally exposed to ethylene oxide展开更多
Ten workers from a cyclotron unit have beenaccidentally exposed to Osmium tetroxide emanations during a fewhours.In vitro,Osmium tetroxide forms an irreversible bindingwith thymidine without apparently disturbance in ...Ten workers from a cyclotron unit have beenaccidentally exposed to Osmium tetroxide emanations during a fewhours.In vitro,Osmium tetroxide forms an irreversible bindingwith thymidine without apparently disturbance in the DNAstructure.展开更多
Since the discovery of chromosomal abnormalitiesspecifically linked to particular types of leukemia,cytogeneticstudies have been shown to be of great contribution not only forthe diagnosis of leukemia but also for pro...Since the discovery of chromosomal abnormalitiesspecifically linked to particular types of leukemia,cytogeneticstudies have been shown to be of great contribution not only forthe diagnosis of leukemia but also for prognosis of patients.Situation is less clear for patients with lymphoma for whichcells are generally more difficult to grow in culture.展开更多
文摘Biomonitoring human exposed to alkylating agents with theSister Chromatid Exchanges assay(SCEs)and especially theHigh Frequency Cells concept(HFCs)is considered as asensitive approach for detecting a personal exposure.Six yearsafter a two-year chronic exposure of primates to EtO,a highlymutagenic agent,an persistently increased SCEs frequency hasrecently been published.In this experiment,the appearance of ahighly mutated subpopulation of cells(the High Frequency
文摘Biomonitoring with cytogenetic methods consistto compare a known or suspected exposed groups with acontrol group with different endpoints.Generallyfactors which may influence the baseline levels ofsister chromatid exchanges frequency fall in 2 cate-gories:technical and biological factors.In additionto age,sex,drug use,smoking habits,health statusmight also be relevant.During a long term survey ofpeople professionally exposed to ethylene oxide
文摘Ten workers from a cyclotron unit have beenaccidentally exposed to Osmium tetroxide emanations during a fewhours.In vitro,Osmium tetroxide forms an irreversible bindingwith thymidine without apparently disturbance in the DNAstructure.
文摘Since the discovery of chromosomal abnormalitiesspecifically linked to particular types of leukemia,cytogeneticstudies have been shown to be of great contribution not only forthe diagnosis of leukemia but also for prognosis of patients.Situation is less clear for patients with lymphoma for whichcells are generally more difficult to grow in culture.
