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PD-1/PD-L1抑制剂联合曲妥珠单抗在HER2阳性乳腺癌中的研究进展 被引量:1
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作者 常晋怡 王维 蔡海峰 《肿瘤防治研究》 CAS CSCD 2022年第9期965-969,共5页
乳腺癌中有20%~30%的患者表达HER2基因,HER2阳性乳腺癌预后较差,易发生复发和转移。但HER2的表达为乳腺癌治疗提供了新方向。曲妥珠单抗是抗HER2治疗的经典基础药物,然而其原发继发耐药问题引起了大家的注意,研究发现其不敏感及耐药机... 乳腺癌中有20%~30%的患者表达HER2基因,HER2阳性乳腺癌预后较差,易发生复发和转移。但HER2的表达为乳腺癌治疗提供了新方向。曲妥珠单抗是抗HER2治疗的经典基础药物,然而其原发继发耐药问题引起了大家的注意,研究发现其不敏感及耐药机制的发生可能与肿瘤细胞表面PD-L1上调相关。因此大量关于PD-1/PD-L1抑制剂联合曲妥珠单抗的研究展开意在提高其敏感度,改善其耐药问题。本文就PD-1/PD-L1抑制剂在HER2阳性乳腺癌的临床前及临床研究作一综述。 展开更多
关键词 PD-1/PD-L1 乳腺癌 HER2 曲妥珠单抗
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A New Method of Semantic Feature Extraction for Medical Images Data
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作者 XIE Conghua SONG Yuqing chang jinyi 《Wuhan University Journal of Natural Sciences》 CAS 2006年第5期1152-1156,共5页
In order to overcome the disadvantages of color, shape and texture-based features definition for medical images, this paper defines a new kind of semantic feature and its extraction algorithm. We firstly use kernel de... In order to overcome the disadvantages of color, shape and texture-based features definition for medical images, this paper defines a new kind of semantic feature and its extraction algorithm. We firstly use kernel density estimation statistical model to describe the complicated medical image data, secondly, define some typical representative pixels of images as feature and finally, take hill-climbing strategy of Artificial Intelligence to extract those semantic features. Results of a content-based medial image retrieve system show that our semantic features have better distinguishing ability than those color, shape and texture-based features and can improve the ratios of recall and precision of this system smartly. 展开更多
关键词 feature extraction kernel density estimation hill-climbing algorithm content-based image retrieve
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