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STAT1 is involved in signal transduction in the EPOinduced HEL cells
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作者 JIANG CHU chang yun gui +2 位作者 JIE FAN XIAO DA TANG RUO LAN QIAO(Shanghai Institute of Cell Biology, Chinese Academy ofSciences, Shanghai 200031, China )(Dept. of Urology, Shanghai First People,s Hospital,Shanghai 200081, China) 《Cell Research》 SCIE CAS CSCD 1998年第2期105-107,共3页
Erythropoietin (EPO) is the ma jor regulator of mammalian erythropoisis, which stimulates the growth and differentiation of hematopoietic cells through interaction with its receptor (EPO-R). Here we use HEL cells (a h... Erythropoietin (EPO) is the ma jor regulator of mammalian erythropoisis, which stimulates the growth and differentiation of hematopoietic cells through interaction with its receptor (EPO-R). Here we use HEL cells (a human erythro-leukemia cell line) as a model to elucidate the pathway of signal transduction in the EPO-induced HEL cells. our data show that the EPOR (EPO receptor) on the surface of HEL cells interacts with the Janus tyrosine protein kinase (Jak2) to transduce intracellular signals through phosphorylation of cytoplasmic proteins in EPO-treated HEL cells. Both STAT1 and STAT5 in this cell line are tyrosine-phosphorylated and translocated to nucleus following the binding of EPO to HEL cells.Furthermore, the binding of both STAT1 and STAT5 proteins to specific DNA elements (SIE and PIE elements) is revealed in an EPO-dependent manner. Our data demonstrate that the pathway of signal transduction following the binding of EPO to HEL cells is similar to immature erythroid cell from the spleen of mice infected with anemia strain of Friend virus. 展开更多
关键词 ERYTHROPOIETIN HEL cells signal transduction
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