Liposomes hold great potential in anti-cancer drug delivery and the targeting treatment of tumors.However,the clinical therapeutic efficacy of liposomes is still limited by the complexity of tumor microenvironment(TME...Liposomes hold great potential in anti-cancer drug delivery and the targeting treatment of tumors.However,the clinical therapeutic efficacy of liposomes is still limited by the complexity of tumor microenvironment(TME)and the insufficient accumulation in tumor sites.Meanwhile,the application of cholesterol and polyethylene glycol(PEG),which are usually used to prolong the blood circulation and stabilize the structure of liposomes respectively,has been questioned due to various disadvantages.Herein,we developed a ginsenoside Rh2-based multifunctional liposome system(Rh2-lipo)to effectively address these challenges once for all.Different with the conventional’wooden’liposomes,Rh2-lipo is a much more brilliant carrier with multiple functions.In Rh2-lipo,both cholesterol and PEG were substituted by Rh2,which works as membrane stabilizer,long-circulating stealther,active targeting ligand,and chemotherapy adjuvant at the same time.Firstly,Rh2 could keep the stability of liposomes and avoid the shortcomings caused by cholesterol.Secondly,Rh2-lipo showed a specifically prolonged circulation behavior in the blood.Thirdly,the accumulation of the liposomes in the tumor was significantly enhanced by the interaction of glucose transporter of tumor cells with Rh2.Fourth,Rh2-lipo could remodel the structure and reverse the immunosuppressive environment in TME.When tested in a 4T1 breast carcinoma xenograft model,the paclitaxel-loaded Rh2-lipo realized high efficient tumor growth suppression.Therefore,Rh2-lipo not only innovatively challenges the position of cholesterol as a liposome component,but also provides another innovative potential system with multiple functions for anti-cancer drug delivery.展开更多
Objective To assess the effect of different levels of salt iodine content on thyroid volume（ThV） distribution using data from the 1999, 2011, and 2014 Chinese national iodine deficiency disorder（IDD） surveys. Meth...Objective To assess the effect of different levels of salt iodine content on thyroid volume（ThV） distribution using data from the 1999, 2011, and 2014 Chinese national iodine deficiency disorder（IDD） surveys. Methods Probability proportion to size（PPS） sampling method was used to obtain a representative national sample of 34,547, 38,932, and 47,188 Chinese children aged 8-10 years in 1999, 2011, and 2014 Chinese national IDD surveys, respectively. The iodine content in household iodized salt and urinary iodine concentration were measured and thyroid ultrasound examination was performed. The data were analyzed by SAS software using histograms and box plots. The skewness and kurtosis were calculated for testing the normality of ThV. Results The median iodine content in household iodized salt dropped from 42.30 mg/kg in 1999 to 25.00 mg/kg in 2014. The median urinary iodine concentration of children aged 8-10 years decreased from 306.0 μg/L in 1999 to 197.9 μg/L in 2014. The median and interquartile range（IQR） of ThV in 1999, 2011, and 2014 surveys were 3.44 m L and 1.50 m L, 2.60 m L and 1.37 m L, 2.63 m L and 1.25 m L, respectively. The skewness and kurtosis of ThV distribution in 1999, 2011, and 2014 surveys were 1.34 and 5.84, 0.98 and 3.54, 1.27 and 5.49, respectively. Conclusion With reduced salt iodization levels, the median urinary iodine concentration and median ThV of children decreased significantly, and the symmetry of the ThV distribution improved.展开更多
Objective This study is to examine the influence of familiarity on energy intake, eating behavior, and concentration of the plasma gut hormones in lean and overweight young male subjects. Methods Twenty-eight lean and...Objective This study is to examine the influence of familiarity on energy intake, eating behavior, and concentration of the plasma gut hormones in lean and overweight young male subjects. Methods Twenty-eight lean and twenty-eight overweight participants were recruited. Their food consumption was documented and analyzed when they had a test meal while they were paired with friends or strangers at the same weight stature. Their eating behavior was recorded with cameras hidden in the carton, and postprandial plasma gut hormone concentration were measured. Results Compared with overweight strangers（OS）, overweight friends（OF） had increased food consumption, prolonged and decreased number of chews per 10 g food. Compared with OS, postprandial plasma concentration of cholecystokinin-8 was significantly lower in OF group at 30, 60, and 90 min, whereas the concentration of glucagon-like peptide 1 was significantly lower at 60 and 90 min. Plasma ghrelin concentration was significantly higher in the OF group than that in the OS group at 90 and 120 min. No significant differences in gut hormone concentration were observed between lean strangers（LS） and lean friends（LF） groups at all time points. Conclusion Familiarity plays an important role in increasing energy intake and in changing of postprandial gut hormone concentration in overweight individuals.展开更多
The interaction mechanism between AC and DC systems in a hybrid AC-DC transmission grid is discussed with PSS/E software. Analysis shows that receiving-end AC faults may cause much more damage on the HVDC system opera...The interaction mechanism between AC and DC systems in a hybrid AC-DC transmission grid is discussed with PSS/E software. Analysis shows that receiving-end AC faults may cause much more damage on the HVDC system operation than the sending-end AC faults in a multi-infeed HVDC system, and the damage severity depends on the power recovering rate of the HVDC systems. For HVDC systems with slow power recovering rate, the receiving-end AC faults may probably be a critical factor to constrain power transfer limits. Larger capacity of HVDC system means not only higher power transfer-limit of the parallel connected AC-DC transmission grid, but also more expensive stabilizing cost.展开更多
Terracotta rider fi gurines are common artifacts in the past, generally combinations of person riding animals like horse or camel, through these organic fi gures we can see vivid pictures of ancient social life and cu...Terracotta rider fi gurines are common artifacts in the past, generally combinations of person riding animals like horse or camel, through these organic fi gures we can see vivid pictures of ancient social life and cultural evolution. A lot of researches on terracotta fi gurines have been reported, but terracotta rider fi gurines have been less studied as an independent object. This paper studied terracotta rider fi gurines, and found that this cultural form originated from the Warring States Period, thrived in the Tang Dynasty, and declined gradually after the Yuan Dynasty. The declination of ancient terracotta rider fi gurine culture owes to the changing social environment in different historical periods. Researches on terracotta rider fi gurines explored social customs and conventions behind them, and provided signifi cant theoretical support for protecting the cultural heritage.展开更多
Objective: To study the relationship of PDCD5 expression with apoptosis, inflammatory factors and MMPs/TIMPs expression in degenerated intervertebral disc tissue. Methods:Patients with lumbar disc herniation who were ...Objective: To study the relationship of PDCD5 expression with apoptosis, inflammatory factors and MMPs/TIMPs expression in degenerated intervertebral disc tissue. Methods:Patients with lumbar disc herniation who were treated in the Seventh People's Hospital of Shanghai between March 2015 and February 2017 were selected as the LDH group and patients with violent thoracolumbar vertebral fracture were selected as the control group. The intervertebral disc tissue was collected to determine the mRNA expression of PDCD5 as well as the protein levels of apoptosis molecules, inflammatory factors and MMPs/TIMPs molecules. Results: PDCD5 mRNA expression in intervertebral disc tissue of LDH group was significantly higher than that of control group;Caspase-3, Caspase-8, Fas, Caspase-9, Bax, SDF-1, CXCR-4, TNF-α, PGE2, MMP1, MMP2, MMP8 and MMP9 protein levels in intervertebral disc tissue of LDH group were significantly higher than those of control group and positively correlated with PDCD5 mRNA expression while TIMP1 and TIMP2 protein levels were significantly lower than those of control group and negatively correlated with PDCD5 mRNA expression. Conclusion: The high expression of PDCD5 in degenerated intervertebral disc tissue can activate apoptosis and inflammatory response and cause MMPs/TIMPs imbalance.展开更多
Transient stability analysis is a key problem in power system operation and planning.This paper aims at giving a comprehensive review on the modeling ideas and analysis methods for transient stability of large-scale p...Transient stability analysis is a key problem in power system operation and planning.This paper aims at giving a comprehensive review on the modeling ideas and analysis methods for transient stability of large-scale power systems.For model construction,the general modeling of traditional power systems and special modeling for renewable generations and high-voltage direct-current transmissions are introduced.For transient stability analysis,Lyapunov based methods and non-Lyapunov based methods are thoroughly reviewed.In Lya-punov based methods,we focus on the energy function method,the sum-of-squares based method and decentralized stability analysis methods.Meanwhile,in non-Lyapunov based methods,the time-domain simulation,extended equal-area criterion and data-driven based methods are considered.The basic working principles,features and recent research progresses of all the above-mentioned methods are described in detail.In particular,their performances on several aspects,such as computational speed,conservativeness of stability region estimation or stability margin calculation,and adaptability to various types of system models,are mentioned.Finally,a brief discussion of potential directions for future research on transient stability analysis of large-scale power systems is included.Index Terms-connective stability,large-scale system analysis,Lyapunov functions,power systems,transient stability analysis.展开更多
基金supported by National Natural Science Foundation of China(Nos.81773911,81690263 and 81573616)the Development Project of Shanghai Peak Disciplines-Integrated Medicine(No.20150407)。
文摘Liposomes hold great potential in anti-cancer drug delivery and the targeting treatment of tumors.However,the clinical therapeutic efficacy of liposomes is still limited by the complexity of tumor microenvironment(TME)and the insufficient accumulation in tumor sites.Meanwhile,the application of cholesterol and polyethylene glycol(PEG),which are usually used to prolong the blood circulation and stabilize the structure of liposomes respectively,has been questioned due to various disadvantages.Herein,we developed a ginsenoside Rh2-based multifunctional liposome system(Rh2-lipo)to effectively address these challenges once for all.Different with the conventional’wooden’liposomes,Rh2-lipo is a much more brilliant carrier with multiple functions.In Rh2-lipo,both cholesterol and PEG were substituted by Rh2,which works as membrane stabilizer,long-circulating stealther,active targeting ligand,and chemotherapy adjuvant at the same time.Firstly,Rh2 could keep the stability of liposomes and avoid the shortcomings caused by cholesterol.Secondly,Rh2-lipo showed a specifically prolonged circulation behavior in the blood.Thirdly,the accumulation of the liposomes in the tumor was significantly enhanced by the interaction of glucose transporter of tumor cells with Rh2.Fourth,Rh2-lipo could remodel the structure and reverse the immunosuppressive environment in TME.When tested in a 4T1 breast carcinoma xenograft model,the paclitaxel-loaded Rh2-lipo realized high efficient tumor growth suppression.Therefore,Rh2-lipo not only innovatively challenges the position of cholesterol as a liposome component,but also provides another innovative potential system with multiple functions for anti-cancer drug delivery.
文摘Objective To assess the effect of different levels of salt iodine content on thyroid volume（ThV） distribution using data from the 1999, 2011, and 2014 Chinese national iodine deficiency disorder（IDD） surveys. Methods Probability proportion to size（PPS） sampling method was used to obtain a representative national sample of 34,547, 38,932, and 47,188 Chinese children aged 8-10 years in 1999, 2011, and 2014 Chinese national IDD surveys, respectively. The iodine content in household iodized salt and urinary iodine concentration were measured and thyroid ultrasound examination was performed. The data were analyzed by SAS software using histograms and box plots. The skewness and kurtosis were calculated for testing the normality of ThV. Results The median iodine content in household iodized salt dropped from 42.30 mg/kg in 1999 to 25.00 mg/kg in 2014. The median urinary iodine concentration of children aged 8-10 years decreased from 306.0 μg/L in 1999 to 197.9 μg/L in 2014. The median and interquartile range（IQR） of ThV in 1999, 2011, and 2014 surveys were 3.44 m L and 1.50 m L, 2.60 m L and 1.37 m L, 2.63 m L and 1.25 m L, respectively. The skewness and kurtosis of ThV distribution in 1999, 2011, and 2014 surveys were 1.34 and 5.84, 0.98 and 3.54, 1.27 and 5.49, respectively. Conclusion With reduced salt iodization levels, the median urinary iodine concentration and median ThV of children decreased significantly, and the symmetry of the ThV distribution improved.
基金supported by the Scientific Research Fund Project of Qiqihar Medical University under grant No.QY2016M-17.The study of social effects on energy intake and plasma gut hormone concentration
文摘Objective This study is to examine the influence of familiarity on energy intake, eating behavior, and concentration of the plasma gut hormones in lean and overweight young male subjects. Methods Twenty-eight lean and twenty-eight overweight participants were recruited. Their food consumption was documented and analyzed when they had a test meal while they were paired with friends or strangers at the same weight stature. Their eating behavior was recorded with cameras hidden in the carton, and postprandial plasma gut hormone concentration were measured. Results Compared with overweight strangers（OS）, overweight friends（OF） had increased food consumption, prolonged and decreased number of chews per 10 g food. Compared with OS, postprandial plasma concentration of cholecystokinin-8 was significantly lower in OF group at 30, 60, and 90 min, whereas the concentration of glucagon-like peptide 1 was significantly lower at 60 and 90 min. Plasma ghrelin concentration was significantly higher in the OF group than that in the OS group at 90 and 120 min. No significant differences in gut hormone concentration were observed between lean strangers（LS） and lean friends（LF） groups at all time points. Conclusion Familiarity plays an important role in increasing energy intake and in changing of postprandial gut hormone concentration in overweight individuals.
文摘The interaction mechanism between AC and DC systems in a hybrid AC-DC transmission grid is discussed with PSS/E software. Analysis shows that receiving-end AC faults may cause much more damage on the HVDC system operation than the sending-end AC faults in a multi-infeed HVDC system, and the damage severity depends on the power recovering rate of the HVDC systems. For HVDC systems with slow power recovering rate, the receiving-end AC faults may probably be a critical factor to constrain power transfer limits. Larger capacity of HVDC system means not only higher power transfer-limit of the parallel connected AC-DC transmission grid, but also more expensive stabilizing cost.
文摘Terracotta rider fi gurines are common artifacts in the past, generally combinations of person riding animals like horse or camel, through these organic fi gures we can see vivid pictures of ancient social life and cultural evolution. A lot of researches on terracotta fi gurines have been reported, but terracotta rider fi gurines have been less studied as an independent object. This paper studied terracotta rider fi gurines, and found that this cultural form originated from the Warring States Period, thrived in the Tang Dynasty, and declined gradually after the Yuan Dynasty. The declination of ancient terracotta rider fi gurine culture owes to the changing social environment in different historical periods. Researches on terracotta rider fi gurines explored social customs and conventions behind them, and provided signifi cant theoretical support for protecting the cultural heritage.
文摘Objective: To study the relationship of PDCD5 expression with apoptosis, inflammatory factors and MMPs/TIMPs expression in degenerated intervertebral disc tissue. Methods:Patients with lumbar disc herniation who were treated in the Seventh People's Hospital of Shanghai between March 2015 and February 2017 were selected as the LDH group and patients with violent thoracolumbar vertebral fracture were selected as the control group. The intervertebral disc tissue was collected to determine the mRNA expression of PDCD5 as well as the protein levels of apoptosis molecules, inflammatory factors and MMPs/TIMPs molecules. Results: PDCD5 mRNA expression in intervertebral disc tissue of LDH group was significantly higher than that of control group;Caspase-3, Caspase-8, Fas, Caspase-9, Bax, SDF-1, CXCR-4, TNF-α, PGE2, MMP1, MMP2, MMP8 and MMP9 protein levels in intervertebral disc tissue of LDH group were significantly higher than those of control group and positively correlated with PDCD5 mRNA expression while TIMP1 and TIMP2 protein levels were significantly lower than those of control group and negatively correlated with PDCD5 mRNA expression. Conclusion: The high expression of PDCD5 in degenerated intervertebral disc tissue can activate apoptosis and inflammatory response and cause MMPs/TIMPs imbalance.
基金supported in part by the State Key Program of National Natural Science Foundation of China under Grant No.U1866210 and Young Elite Scientists Sponsorship Program by CSEE underGrant No.CSEE-YESS-2018.
文摘Transient stability analysis is a key problem in power system operation and planning.This paper aims at giving a comprehensive review on the modeling ideas and analysis methods for transient stability of large-scale power systems.For model construction,the general modeling of traditional power systems and special modeling for renewable generations and high-voltage direct-current transmissions are introduced.For transient stability analysis,Lyapunov based methods and non-Lyapunov based methods are thoroughly reviewed.In Lya-punov based methods,we focus on the energy function method,the sum-of-squares based method and decentralized stability analysis methods.Meanwhile,in non-Lyapunov based methods,the time-domain simulation,extended equal-area criterion and data-driven based methods are considered.The basic working principles,features and recent research progresses of all the above-mentioned methods are described in detail.In particular,their performances on several aspects,such as computational speed,conservativeness of stability region estimation or stability margin calculation,and adaptability to various types of system models,are mentioned.Finally,a brief discussion of potential directions for future research on transient stability analysis of large-scale power systems is included.Index Terms-connective stability,large-scale system analysis,Lyapunov functions,power systems,transient stability analysis.
