Failure transition of shear-to-dilation band of rock salt under triaxial stresses

Great potential of underground gas/energy storage in salt caverns seems to be a promising solution to support renewable energy.In the underground storage method,the operating cycle unfortunately may reach up to daily or even hourly,which generates complicated pressures on the salt cavern.Furthermore,the mechanical behavior of rock salt may change and present distinct failure characteristics under different stress states,which affects the performance of salt cavern during the time period of full service.To reproduce a similar loading condition on the cavern surrounding rock mass,the cyclic triaxial loading/unloading tests are performed on the rock salt to explore the mechanical transition behavior and failure characteristics under different confinement.Experimental results show that the rock salt samples pre-sent a diffused shear failure band with significant bulges at certain locations in low confining pressure conditions(e.g.5 MPa,10 MPa and 15 MPa),which is closely related to crystal misorientation and grain boundary sliding.Under the elevated confinement(e.g.20 MPa,30 MPa and 40 MPa),the dilation band dominates the failure mechanism,where the large-size halite crystals are crushed to be smaller size and new pores are developing.The failure transition mechanism revealed in the paper provides additional insight into the mechanical performance of salt caverns influenced by complicated stress states.

A creep model for ultra-deep salt rock considering thermal-mechanical damage under triaxial stress conditions

To investigate the specific creep behavior of ultra-deep buried salt during oil and gas exploitation,a set of triaxial creep experiments was conducted at elevated temperatures with constant axial pressure and unloading confining pressure conditions.Experimental results show that the salt sample deforms more significantly with the increase of applied temperature and deviatoric loading.The accelerated creep phase is not occurring until the applied temperature reaches 130℃,and higher temperature is beneficial to the occurrence of accelerated creep.To describe the specific creep behavior,a novel three-dimensional(3D)creep constitutive model is developed that incorporates the thermal and mechanical variables into mechanical elements.Subsequently,the standard particle swarm optimization(SPSO)method is adopted to fit the experimental data,and the sensibility of key model parameters is analyzed to further illustrate the model function.As a result,the model can accurately predict the creep behavior of salt under the coupled thermo-mechanical effect in deep-buried condition.Based on the research results,the creep mechanical behavior of wellbore shrinkage is predicted in deep drilling projects crossing salt layer,which has practical implications for deep rock mechanics problems.

High-Quality van der Waals Epitaxial CsPbBr_(3)Film Grown on Monolayer Graphene Covered TiO_(2)for High-Performance Solar Cells

Two-dimensional materials have been widely used to tune the growth and energy-level alignment of perovskites.However,their incomplete passivation and chaotic usage amounts are not conducive to the preparation of highquality perovskite films.Herein,we succeeded in obtaining higher-quality CsPbBr_(3)films by introducing large-area monolayer graphene as a stable physical overlay on top of TiO_(2)substrates.Benefiting from the inert and atomic smooth graphene surface,the CsPbBr_(3)film grown on top by the van der Waal epitaxy has higher crystallinity,improved(100)orientation,and an average domain size of up to 1.22μm.Meanwhile,a strong downward band bending is observed at the graphene/perovskite interface,improving the electron extraction to the electron transport layers(ETL).As a result,perovskite film grown on graphene has lower photoluminescence(PL)intensity,shorter carrier lifetime,and fewer defects.Finally,a photovoltaic device based on epitaxy CsPbBr_(3)film is fabricated,exhibiting power conversion efficiency(PCE)of up to 10.64%and stability over 2000 h in the air.

Warhead fragments motion trajectories tracking and spatio-temporal distribution reconstruction method based on high-speed stereo photography

High speed photography technique is potentially the most effective way to measure the motion parameter of warhead fragment benefiting from its advantages of high accuracy,high resolution and high efficiency.However,it faces challenge in dense objects tracking and 3D trajectories reconstruction due to the characteristics of small size and dense distribution of fragment swarm.To address these challenges,this work presents a warhead fragments motion trajectories tracking and spatio-temporal distribution reconstruction method based on high-speed stereo photography.Firstly,background difference algorithm is utilized to extract the center and area of each fragment in the image sequence.Subsequently,a multi-object tracking(MOT)algorithm using Kalman filtering and Hungarian optimal assignment is developed to realize real-time and robust trajectories tracking of fragment swarm.To reconstruct 3D motion trajectories,a global stereo trajectories matching strategy is presented,which takes advantages of epipolar constraint and continuity constraint to correctly retrieve stereo correspondence followed by 3D trajectories refinement using polynomial fitting.Finally,the simulation and experimental results demonstrate that the proposed method can accurately track the motion trajectories and reconstruct the spatio-temporal distribution of 1.0×10^(3)fragments in a field of view(FOV)of 3.2 m×2.5 m,and the accuracy of the velocity estimation can achieve 98.6%.

Boosting Peroxymonosulfate Activation via Co-Based LDH-Derived Magnetic Catalysts:A Dynamic and Static State Assessment of Efficient Radical-Assisted Electron Transfer Processes

Heterogeneous catalysts promoting efficient production of reactive species and dynamically stabilized electron transfer mechanisms for peroxomonosulfates(PMS)still lack systematic investigation.Herein,a more stable magnetic layered double oxides(CFLDO/N-C),was designed using self-polymerization and high temperature carbonization of dopamine.The CFLDO/N-C/PMS system effectively activated PMS to remove 99%(k=0.737 min^(-1))of tetracycline(TC)within 10 min.The CFLDO/N-C/PMS system exhibited favorable resistance to inorganic anions and natural organics,as well as satisfactory suitability for multiple pollutants.The magnetic properties of the catalyst facilitated the separation of catalysts from the liquid phase,resulting in excellent reproducibility and effectively reducing the leaching of metal ions.An electronic bridge was constructed between cobalt(the active platform of the catalyst)and PMS,inducing PMS to break the O-O bond to generate the active species.The combination of static analysis and dynamic evolution confirmed the effective adsorption of PMS on the catalyst surface as well as the strong radical-assisted electron transfer process.Eventually,we further identified the sites where the reactive species attacked the TC and evaluated the toxicity of the intermediates.These findings offer innovative insights into the rapid degradation of pollutants achieved by transition metals in SR-AOPs and its mechanistic elaboration.

丝素蛋白对皮肤光损伤的保护作用

丝素蛋白是一种从蚕丝中提取的天然高分子纤维蛋白,有很好的抗氧化和减少光损伤的作用。为了研究丝素蛋白对皮肤光损伤的保护作用,以UVB诱导人角质形成细胞(HaCaT)损伤为模型,通过ELISA和荧光检测细胞内活性氧(ROS)和钙离子(Ca^(2+))的水平,采用免疫荧光检测瞬时受体电位阳离子通道亚家族V成员1(TRPV1)和Claudin-1的表达。此外,还使用蛋白质印迹分析了紧密连接相关蛋白Occludin和Claudin-1的表达。结果表明,120 m J/cm^(2)的UVB刺激显著降低细胞活力,而100μg/m L丝素蛋白的存在显著增加细胞活力。UVB刺激导致细胞内活性氧水平升高,激活TRPV1通道,诱导细胞内Ca^(2+)水平增加。同时炎症因子白细胞介素1α(IL-1α)(P<0.01)和S100钙结合蛋白A8(S100A8)(P<0.05)水平也显著升高,引发炎症反应。添加丝素蛋白的HaCaT细胞受到UVB的影响则显著降低(P<0.05)。实验证明,UVB会破坏屏障蛋白,导致屏障蛋白Claudin-1和Occludin的表达下降。丝素蛋白的加入可以降低这种影响,保护细胞间紧密连接。因此,丝素蛋白可能具有降低氧化应激、屏障损伤和炎症发生,保护皮肤免受UVB诱导的光损伤的潜在能力。

Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis

Rheumatoid arthritis(RA)is an autoimmune disease.Early studies hold an opinion that gut microbiota is environmentally acquired and associated with RA susceptibility.However,accumulating evidence demonstrates that genetics also shape the gut microbiota.It is known that some strains of inbred laboratory mice are highly susceptible to collagen-induced arthritis(CIA),while the others are resistant to CIA.Here,we show that transplantation of fecal microbiota of CIA-resistant C57BL/6J mice to CIA-susceptible DBA/1J mice confer CIA resistance in DBA/1J mice.C57BL/6J mice and healthy human individuals have enriched B.fragilis than DBA/1J mice and RA patients.Transplantation of B.fragilis prevents CIA in DBA/1J mice.We identify that B.fragilis mainly produces propionate and C57BL/6J mice and healthy human individuals have higher level of propionate.Fibroblast-like synoviocytes(FLSs)in RA are activated to undergo tumor-like transformation.Propionate disrupts HDAC3-FOXK1 interaction to increase acetylation of FOXK1,resulting in reduced FOXK1 stability,blocked interferon signaling and deactivation of RA-FLSs.We treat CIA mice with propionate and show that propionate attenuates CIA.Moreover,a combination of propionate with anti-TNF etanercept synergistically relieves CIA.These results suggest that B.fragilis or propionate could be an alternative or complementary approach to the current therapies.

High-Performance Inverted Perovskite Solar Cells with Sol-Gel-Processed Sliver-Doped NiO_(x)Hole Transporting Layer

Nickel oxide(NiO_(x))has been established as a highly efficient and stable holetransporting layer(HTL)in perovskite solar cells(PSCs).However,existing deposition methods for NiO_(x)have been restricted by high-vacuum processes and fail to address the energy level mismatch at the NiO_(x)/perovskite interface,which has impeded the development of PSCs.Accordingly,we explored the application of NiO_(x)as a hybrid HTL through a sol-gel process,where a NiO_(x)film was pre-doped with Ag ions,forming a p/p^(+)homojunction in the NiO_(x)-based inverted PSCs.This innovative approach offers two synergistic advantages,including the enlargement of the built-in electric field for facilitating charge separation,optimizing energy level alignment,and charge transfer efficiency at the interface between the perovskite and HTL.Incorporating this hybrid HTL featuring the p/p^(+)homojunction in the inverted PSCs resulted in a high-power conversion efficiency(PCE)of up to 19.25%,significantly narrowing the efficiency gap compared to traditional n-i-p devices.Furthermore,this innovative strategy for the HTL enhanced the environmental stability to 30 days,maintaining 90%of the initial efficiency.

Clinical Value of Echocardiographic Screening and Dynamic Observations for Ductus Arteriosus Closure in Newborns

Objective:To explore and analyze the clinical value of echocardiography screening and dynamic observation for ductus arteriosus closure in newborns.Methods:The study was conducted from August 2022 to December 2023.500 newborns who were admitted to our hospital were selected as research subjects for this study(Kunming Tongren Hospital).All subjects underwent echocardiography to determine the severity of patent ductus arteriosus(PDA).The inner diameter of the pulmonary artery was measured,and the pulmonary artery pressure was estimated through tricuspid regurgitation.If the patient had high pulmonary artery pressure,elective closure surgery was performed.Results:Among the 500 subjects,448 cases of ductus arteriosus closure and 52 cases of PDA were detected by echocardiography,including 23 cases of simple PDA,15 cases with patent foramen ovale,11 cases with atrial septal defect,1 case with muscular ventricular septal defect,1 case with tricuspid valve prolapse,and 1 case with tricuspid valve chordae tendineae rupture.After symptomatic treatment and intervention,their echocardiogram results were reviewed and no abnormalities were found.All measurement results of children with PDA combined with pulmonary hypertension were better than before treatment(P<0.05).Conclusion:Echocardiography is a fast,accurate,and reliable non-invasive imaging examination technology.It can significantly improve congenital heart disease detection rate in infants and young children.Early intervention based on the examination results can dramatically improve the quality of life of infants and young children with PDA.

定期健康体检对改善老年人遵医行为的效果观察

目的探讨定期健康体检对改善老年人遵医行为的效果。方法将2017年5月至2018年6月于该院体检科进行健康体检的120例老年人纳入研究,其中60例定期接受健康体检的老年人设为研究组,其余60例未定期接受健康体检的老年人设为对照组。将两组遵医行为、生活质量、护理满意度作为观察指标进行分析对比。结果相对于对照组,研究组的疾病认知水平、遵医嘱用药、自我健康管理各项评分明显提高,差异均有统计学意义(P<0.05);研究组躯体角色、躯体功能、生命力、健康状况、心理健康、社会功能、情感角色各项生活质量评分显著高于对照组,差异均有统计学意义(P<0.05);研究组护理满意度为96.67%,显著高于对照组的86.67%,差异有统计学意义(P<0.05)。结论通过定期健康体检可早期发现机体异常改变,进一步提高老年人遵医行为,改善生活质量,同时提高护理满意度,具有良好社会效益与经济效益。

Histopathologic and Immunohistochemical Analysis of 66 Cases of Gastrointestinal Stromal Tumor

Background and Objective: To investigate the histopathological characteristics and immunohistochemistry of gastrointestinal stromal tumors (GIST). Immunohistochemistry (IHC) refers to the expression and meaning of CD117, DOG-1, CD34. Methods: Sixty-six gastrointestinal stromal tumor (GIST) samples with complete clinical data and definite clinicopathological diagnosis were collected from the Seventh Affiliated Hospital of Sun Yat-sen University from January 2019 to December 2022. Retrospective analysis was performed on the pathological data of 66 patients with GIST, and the histopathology and IHC were analyzed and summarized. Results: Among the 66 cases, 46, 14, 1, 5 were found in the stomach, small intestine, large intestine, and gastroenteral area. There were 45 cases (97%), 11 cases (79%), 1 case (100%), 5 cases (100%) in order of fusiform cell type. There were 1 case (3%), 2 cases (14%), 0 case, 0 case of upper dermatiform;Mixed type in 0 case, 1 case (7%), 0 case, 0 case;CD117 positive 66 cases (100%), DOG-1 positive 66 cases (100%), CD34 positive 61 cases (92%), CD117 and/or CD34 negative 5 cases (8%);CD34, CD117 and DOG-1 were negative simultaneously in 0 case. 19 cases (28%) were positive for SMA and 7 cases (11%) were positive for S-100. Conclusion: Fusiform cell type is the common type of GIST, followed by epithelioid type and mixed type, but the tumor sites are different, and the comparison cases are not completely the same. CD117, DOG-1 and CD34 are high surface in GIST, and the combination of SMA, S-100 and histomorphology can be used to diagnose most GIST.

Clinicopathologic Characteristics of Differentiated Thyroid Carcinoma in Children and Adolescents

Objective: To investigate the clinicopathologic features of differentiated thyroid carcinoma in children and adolescents. Methods: The clinical data of 7 children and adolescents with differentiated thyroid carcinoma were retrospectively analyzed, and the clinicopathologic features of differentiated thyroid carcinoma were analyzed by gender, tumor size and BRAF mutation. Results: There were 7 cases of thyroid papillary carcinoma. The mean age of patients was (18.71 ± 2.75), and the mean tumor diameter was (2.4 ± 1.04) cm. Lymph node metastasis rate was 100% (7/7). In children and adolescents, the lesion volume was larger, membrane invasion and vascular cancer thrombus were more likely to occur, BRAF mutation was less common, and the difference was statistically significant. Conclusion: Children and adolescents with differentiated thyroid carcinoma are more aggressive and prone to membrane invasion and lymph node metastasis;BRAF mutation is less common than in adults.

Tubular Carcinoma of the Breast: A Clinicopathological Analysis of Two Cases

Tubular Carcinoma (TC) of the breast, also known as tubular carcinoma or well-differentiated adenocarcinoma, is defined as a special type of breast cancer consisting of well-differentiated tubular structures with excellent prognosis by WHO (2019) pathological and genetic classification of breast neoplasms. Two cases of breast tubular carcinoma admitted to our hospital were reported. The relevant literature was reviewed and the clinical features, histological morphology (microscopic features and differential diagnosis), molecular changes and clinical prognosis were summarized.

经颏下前庭入路腔镜甲状腺乳头状癌手术的短期临床效果

目的:探讨经颏下前庭入路腔镜甲状腺乳头状癌手术的短期临床效果。方法:回顾性分析2020年11月-2022年6月于九江市第一人民医院行腔镜甲状腺乳头状癌手术的80例患者的病历资料,根据其手术入路方式分为颏下组(40例)和口腔组(40例),颏下组患者行经颏下前庭入路腔镜甲状腺乳头状癌手术;口腔组患者行经口腔前庭入路腔镜甲状腺乳头状癌手术。比较两组手术情况、术后情况、应激反应、手术并发症发生情况。结果:两组操作空间建立时间比较,差异无统计学意义(P>0.05);颏下组手术时间短于口腔组,术中出血量低于口腔组(P<0.05);颏下组术后VAS评分、术后引流量均低于口腔组,且引流管留置时间及术后住院时间均短于口腔组(P<0.05);术后3 d,两组PGE2、IL-6及Cor水平均较术前上升,但颏下组PGE2、IL-6及Cor水平均低于口腔组(P<0.05);颏下组手术并发症发生率低于口腔组(P<0.05)。结论:经颏下前庭入路腔镜甲状腺乳头状癌手术可有助于节省手术时间,降低手术创伤和并发症发生风险,促进术后恢复。

经口前庭入路腔镜下早期甲状腺癌根治术的临床研究

目的 分析经口前庭入路腔镜下早期甲状腺癌根治术(transoral endascopic thyroidectomy,TOET)的临床效果。方法 选取2019年1月—2021年1月九江市第一人民医院适合腔镜手术且病理确诊分化型甲状腺癌(直径≤2 cm)的50例患者,按照手术方式的不同分成观察组和对照组,每组25例。对照组进行传统开放式手术,观察组采用经口腔前庭入路腔镜下早期甲状腺癌根治术,对比2组治疗效果。结果 观察组缓解率高于对照组,观察组的手术时间、住院时间短于对照组,术中出血量少于对照组,观察组的中央区淋巴结清扫数量多于对照组,差异有统计学意义(P<0.05)。2组并发症发生率比较差异无统计学意义(P>0.05)。术前,2组C-反应蛋白(C-reactive protein,CRP)、皮质醇(cortisol,Cor)水平比较,差异无统计学意义(P>0.05);术后,2组的CRP均高于术前,但观察组CRP低于对照组(P<0.05),2组Cor水平均低于术前(P<0.05),差异无统计学意义(P>0.05)。术后第1天和第3天观察组视觉模拟评分(visual analogue scale,VAS)低于对照组,差异有统计学意义(P<0.05)。观察组切口满意度显著高于对照组(P<0.05)。结论 TOET安全有效,切口外观满意度高,能减少患者的疼痛和应激反应,整体效果良好,值得推广。

跌水结构参数对水中溶解氧含量的影响

文章通过对不同高度、宽度和水垫深度等跌水结构参数进行比较,分析了不同流量下跌水结构参数与跌水水流形态、水中溶解氧含量变化的关系。结果表明:水流脱离跌坎后,在空中跌落过程中会形成水幕状或汇聚为水柱状,相同流量下,水幕状跌水溶解氧含量增加量大于水柱状;随着跌水流量、高度及宽度的增加,跌水曝气的充氧能力显著变大,但随着跌水水垫深度的增加而减少。

不同钙离子浓度下铜对磺胺嘧啶在土壤中的吸附/解吸特征

为探究重金属-抗生素共存时环境条件对土壤吸附/解吸抗生素的影响,通过批次平衡试验研究不同Ca^(2+)浓度下Cu^(2+)对磺胺嘧啶(SDZ)在土壤上的吸附和解吸行为及其交互作用。结果表明,Cu^(2+)浓度的增大显著促进了土壤对SDZ的吸附,同时Ca^(2+)的竞争吸附会抑制这种促进作用。Freundlich、Langmuir模型能较好地拟合SDZ在土壤中的吸附曲线,其拟合相关系数(R2)均大于0.90,而滞后系数(HI)在0.726~1.155,接近于1,表明土壤对SDZ的吸附和解吸过程中没有明显的滞后现象。吉布斯自由能变化量(ΔG)在-20.051~-17.468 kJ/mol,|ΔG|均低于40 kJ/mol,是物理吸附;而进一步的傅里叶红外光谱(FTIR)分析表明,Cu^(2+)和SDZ在土壤中的主要吸附机制是物理吸附,伴随着氢键效应和络合作用。从一定意义上说明,Cu^(2+)可明显提高SDZ在土壤中固持能力,降低其环境迁移的危险性。

腹腔镜全结肠系膜切除术与传统开放术式治疗右半结肠癌的临床效果对比

目的:比较腹腔镜下全结肠系膜切除(complete mesocolic excision,CME)术与传统开放术式治疗右半结肠癌的临床效果。方法:回顾性选取2015年6月-2019年6月于九江市第一人民医院行传统开腹手术的60例右半结肠癌患者作为对照组;收集2017年6月-2021年6月于本院行腹腔镜CME术的60例右半结肠癌患者作为观察组。比较两组围术期指标、手术前后应激反应指标变化情况、手术前后肿瘤标志物含量以及术后并发症的发生情况。结果:两组手术时间、淋巴结清扫数目、术前糖类抗原19-9(CA19-9)、癌胚抗原(CEA)含量比较,差异均无统计学意义(P>0.05),但观察组术中出血量少于对照组,术后引流时间、术后首次下床活动时间以及住院时间均短于对照组(P<0.05)。观察组术后血管紧张素Ⅱ(AngⅡ)、去甲肾上腺素(NE)、肾上腺素(E)、皮质醇(Cor)水平均低于对照组(P<0.05)。两组术后CA19-9、CEA均较术前降低(P<0.05),但组间比较差异均无统计学意义(P>0.05);观察组术后并发症发生率明显低于对照组(P<0.05)。结论:腹腔镜CME术治疗右半结肠癌具有显著的临床效果,可在保证手术切除效果的同时有效提高手术的安全性,减轻患者应激创伤反应的严重程度,有利于患者术后早期恢复,提高术后短期疗效,显著降低术后并发症的发生率。

Overaccumulation of glycine betaine makes the function of the thylakoid membrane better in wheat under salt stress

Wheat(Triticum aestivum L.) lines T1, T4, and T6 were genetically modified to increase glycine betaine(GB) synthesis by introduction of the BADH(betaine aldehyde dehydrogenase, BADH)gene from mountain spinach(Atriplex hortensis L.). These transgenic lines and WT of wheat(T. aestivum L.) were used to study the effect of increased GB synthesis on wheat tolerance to salt stress. Salt stress due to 200 mmol L-1Na Cl impaired the photosynthesis of the four wheat lines, as indicated by declines in net photosynthetic rate(Pn), stomatal conductance(Gs),maximum photochemical efficiency of PSII(Fv/Fm), and actual photochemical efficiency of PSII(ФPSII) and an increase in intercellular CO2concentration(Ci). In comparison with WT, the effect of salinity on the three transgenic lines was mild. Salt stress caused disadvantageous changes in lipids and their fatty acid compositions in the thylakoid membrane of the transgenic lines and WT. Under salt stress, the three transgenic lines showed slightly higher chlorophyll and carotenoid contents and higher Hill reaction activities and Ca2+-ATPase activity than WT. All the results suggest that overaccumulation of GB resulting from introduction of the BADH gene can enhance the salt tolerance of transgenic plants, especially in the protection of the components and function of thylakoid membranes, thereby making photosynthesis better. Changes in lipids and fatty acid compositions in the thylakoid membrane may be involved in the increased salt stress tolerance of the transgenic lines.

High-performance flexible perovskite photodetectors based on single-crystal-like two-dimensional Ruddlesden-Popper thin films

Two-dimensional Ruddlesden-Popper(2DRP)perovskites have attracted intense research interest for optoelectronic applications,due to their tunable optoelectronic properties and better environmental stability than their threedimensional counterparts.Furthermore,high-performance photodetectors based on single-crystal and polycrystalline thin-films 2DRP perovskites have shown great potential for practical application.However,the complex growth process of single-crystal membranes and uncontrollable phase distribution of polycrystalline films hinder the further development of 2DRP perovskites photodetectors.Herein,we report a series of high-performance photodetectors based on single-crystal-like phase-pure 2DRP perovskite films by designing a novel spacer source.Experimental and theoretical evidence demonstrates that phase-pure films substantially suppress defect states and ion migration.These highly sensitive photodetectors show I_(light)/I_(dark) ratio exceeding 3×10^(4),responsivities exceeding 16 A/W,and detectivities exceeding 3×10^(13) Jones,which are higher at least by 1 order than those of traditional mixed-phase thinfilms 2DRP devices(close to the reported single-crystal devices).More importantly,this strategy can significantly enhance the operational stability of optoelectronic devices and pave the way to large-area flexible productions.